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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
65 Results for "
IGF2
" in MedChemExpress (MCE) Product Catalog:
Products (65)
65 Results for "IGF2" in MCE Product Catalog:
6
6 Publications Verification
CWI1-2 is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects .
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6 Publications Verification
CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects .
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Chromeceptin (94G6) is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 expression at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the phosphorylation levels of AKT and mTOR .
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1 Cited Publications
Cat. No.: HY-P99294
CAS No.: 905703-97-1
Synonyms: AMG 479; Human Anti-IGF1R Recombinant Antibody
1
1 Cited Publications
Cat. No.: HY-P99274
CAS No.: 1417158-65-6
Synonyms: BI 836845; Anti-Human IGF1 and IGF2 Recombinant Antibody
1
Cat. No.: HY-174228
CAS No.: 552829-57-9
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I3IN-002 is a small-molecule RNA-binding protein IGF2BP3 inhibitor with an IC50 value of approximately 2 μM in SEM cells. I3IN-002 interferes with interaction with m6 A-modified mRNAs, disrupting the stabilization of target genes (such as CDK6, MYC, and BCL2) to inhibit leukemic cell growth, induce cell cycle arrest, and promote apoptosis. I3IN-002 is promising for research of B-cell acute lymphoblastic leukemia [2].
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AVJ16 is a cancer cell migration inhibitor that targets the insulin-like growth factor 2 mRNA binding protein IGF2BP1 with a good affinity of Kd of 1.4μM. AVJ16 interferes with IGF2BP1 binding target mRNA to regulate gene expression and translation .
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BTYNB is a structure-specific nucleic acid binder and IGF2BP1 inhibitor (with an IC50 of 5 μM against hBTYNB). BTYNB disrupts the IGF2BP1-RNA interaction and blocks its binding to oncogenic mRNAs such as c-Myc, MDM2, PD-L1. BTYNB completely blocks the INHBA-Smad2/3 pathway, disrupts the MYCN/IGF2BP1 loop, and thereby induces apoptosis and cell cycle arrest, effectively inhibiting the proliferation and survival of cancer cells. In addition, BTYNB acts as an immune activator and tumor microenvironment modulator, enhances T cell-mediated tumor killing, and produces significant synergistic effects with inhibitors of PD-1, BRD and BIRC5. BTYNB can be used in relevant research on various malignant tumors including ovarian cancer, neuroblastoma, leukemia and melanoma [2] .
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IGF2BP1-IN-1, a Cucurbitacin B (HY-N0416) derivative is a potent IGF2BP1 inhibitor (KD = 2.88 nM). IGF2BP1-IN-1 binds directly to IGF2BP1, thereby inducing tumor cell cycle arrest, increasing apoptosis, and reducing autophagy. IGF2BP1-IN-1 can be used in research on NSLSC, colon, breast, liver, ovarian, pancreatic, and cervical cancers .
Cat. No.: HY-176471
CAS No.: 3070282-38-8
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IGF2BP3-IN-1 (Compound I3IN-122) is an IGF2BP3 (a RNA binding protein) inhibitor (IC50: > 50 μM), and can be used for cancer research .
Cat. No.: HY-RS06618
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IGF2 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06620
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IGF2BP2 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2BP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS16571
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Igf2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Igf2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P990441
Synonyms: DX-2647
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Cat. No.: HY-RS06619
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IGF2BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06621
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IGF2BP3 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2BP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P99867
CAS No.: 1204390-13-5
Synonyms: MEDI 573
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Cat. No.: HY-174653
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Human IGF2 mRNA encodes the human insulin like growth factor 2 (IGF2) protein, a member of the insulin family of polypeptide growth factors. IGF2 plays a key role in regulating fetoplacental development and also involves in tissue differentiation.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
