552829-57-9
Chemical Structure
I3IN-002
- CAS No.: 552829-57-9
- Formula:C20H16F3N5OS
- Molecular Weight:431.43
InChIKey: ZQCIRLNZPPZIJM-UHFFFAOYSA-N
SMILES: O=C(NC1=C(C(F)(F)F)C=CC=C1)CSC(N=N2)=NC3=C2C4=CC(CC)=CC=C4N3
Biological Activity: I3IN-002 is a small-molecule RNA-binding protein IGF2BP3 inhibitor with an IC50 value of approximately 2 μM in SEM cells. I3IN-002 interferes with interaction with m6 A-modified mRNAs, disrupting the stabilization of target genes (such as CDK6, MYC, and BCL2) to inhibit leukemic cell growth, induce cell cycle arrest, and promote apoptosis. I3IN-002 is promising for research of B-cell acute lymphoblastic leukemia[1][2].
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I3IN-002 | 99.35% | I3IN-002 is a small-molecule RNA-binding protein IGF2BP3 inhibitor with an IC50 value of approximately 2 μM in SEM cells. I3IN-002 interferes with interaction with m6 A-modified mRNAs, disrupting the stabilization of target genes (such as CDK6, MYC, and BCL2) to inhibit leukemic cell growth, induce cell cycle arrest, and promote apoptosis. I3IN-002 is promising for research of B-cell acute lymphoblastic leukemia. | ||||||||||||||||||||
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- [1]. Sharma G, et al. Metabolic regulation of RNA methylation by the m6A-reader IGF2BP3. bioRxiv [Preprint]. 2024 Nov 3:2024.10.31.621399. [Content Brief]
- [2]. Jaiswal A K, et al. A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity[J]. bioRxiv, 2025: 2025.04. 14.648780.
Keywords
