Search Result

Results for "

IPK Superfamily

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Akt (2) Anaplastic lymphoma kinase (ALK) (6) Arf Family GTPase (1) ATP-binding cassette (ABC) transporters (1) Bacterial (2) Biochemical Assay Reagents (1) c-Met/HGFR (1) CD28 (2) CGRP Receptor (2) Endogenous Metabolite (6) ERK (2) Fluorescent Dye (1) Fungal (1) Glutathione Peroxidase (1) Glutathione S-transferase (1) Histone Demethylase (1) Interleukin Related (1) MEK (2) mRNA (27) Orexin Receptor (OX Receptor) (1) Orphan Nuclear Receptor (2) PD-1/PD-L1 (2) Phosphodiesterase (PDE) (1) Phospholipase (3) PPAR (2) Ras (6) Reference Standards (1) Ser/Thr Protease (2) TGF-beta/Smad (3) TGF-β Receptor (2) TNF Receptor (5)
By Research Areas:	Cancer (42) Cardiovascular Disease (7) Endocrinology (3) Infection (3) Inflammation/Immunology (21) Metabolic Disease (12) Neurological Disease (2)
Oligonucleotides:	Antigens (2) CAR-T (1) Transcription Factors (1) mRNA (27) Cholesterol (1) Interleukin & Receptors (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Peptides

Inhibitory Antibodies

Natural
Products

312

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: IPK Superfamily SPFH Protein Superfamily

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112473

Grassofermata Maximum Cited Publications 11 Publications Verification NAV-2729	Ras	Cancer
Grassofermata is a dual Arf1/Arf6 activation inhibitor. ADP ribosylation factors (Arfs) are members of the Arf family of GTP-binding proteins of the Ras superfamily.

HY-133122

UCB-9260 3 Publications Verification	TNF Receptor	Inflammation/Immunology Cancer
UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar K_d of 13 nM .

HY-P2812

Phospholipase D, Streptomyces chromofuscus PLD	Phospholipase	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Phospholipase D, Streptomyces chromofuscus (PLD) is an enzyme of the phospholipase superfamily, which widely exists in bacteria, yeast, plants, animals and viruses, and is often used in biochemical research. Phospholipase D can catalyze the hydrolysis of phosphodiester bonds in glycerophospholipids to produce phosphatidic acid and soluble choline. Phospholipase D is involved in a variety of disease-related processes, including diabetes, atherogenesis, obesity, tumorigenesis, immune response, and neuroendocrine function .

HY-125017

Bozitinib 1 Publications Verification PLB-1001; CBT-101; Vebreltinib	c-Met/HGFR	Cancer
Bozitinib (PLB-1001) is a highly selective c-MET kinase inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) is a ATP-competitive small-molecule inhibitor, binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily .

HY-P99720

Luspatercept 5 Publications Verification ACE-536; luspatercept–aamt	TGF-beta/Smad	Metabolic Disease Cancer
Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia .

HY-P99590A

Sotatercept (mIgG2a) 1 Publications Verification RAP-011	TGF-β Receptor TGF-beta/Smad	Cardiovascular Disease Metabolic Disease
Sotatercept (mIgG2a) (RAP-011), the murine homolog of Sotatercept (ACE-011) (HY-P99590), is a soluble activin receptor type IIA (ActRIIA) ligand trap. Sotatercept (mIgG2a) inhibits the binding of activin A and other members of the TGF-β superfamily (such as Activin A/B, GDF11 and BMP9/10) to their receptors by combining and neutralizing them, thereby regulating cell proliferation and differentiation. Sotatercept (mIgG2a) mainly inhibits the SMAD2/3 signaling pathway, and can be used in various diseases such as chronic kidney disease. Sotatercept (mIgG2a) reduces the expression of erythropoietic hepcidin (ERFE), regulates iron metabolism, and promotes red blood cell production. Sotatercept (mIgG2a) has a dual effect of promoting bone formation (anabolic) and inhibiting bone resorption (catabolic) .

HY-126666

PNU-159682 carboxylic acid	ADC Payload	Inflammation/Immunology Cancer
PNU-159682 carboxylic acid (Compound 53) is a potent ADCs cytotoxin and encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. PNU-159682 carboxylic acid has protein fold and diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response .

HY-P990070

Zigakibart BION-1301	TNF Receptor
Zigakibart (BION-1301) is an IgG4-kappa, humanized monoclonal antibody against TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256). Zigakibart exhibits anti-inflammatory activity .

HY-107823

Cholesteryl acetate Cholesterol 3-acetate; Cholesterin acetate; Cholesterol 3β-acetate	Endogenous Metabolite	Others
Cholesteryl acetate (Cholesterol 3-acetate) is a cholesterol ester that is exported from Saccharomyces cerevisiae via a Pry1-dependent mechanism. Cholesteryl acetate binds to the CAP superfamily protein Pry1 via interactions dependent on Pry1’s caveolin-binding motif .

HY-78349

A 77-01 2 Publications Verification	TGF-β Receptor	Cancer
A 77-01 is a potent inhibitor of transforming growth factor (TGF)-β type I receptor superfamily activin-like kinase ALK5 with an IC₅₀ of 25 nM .

HY-E70518

Oxalate decarboxylase, Microorganism	Bacterial	Infection
Oxalate decarboxylase, Microorganism (EC 4.1.1.2), a stress-response enzyme in certain soil bacteria, is a Mn-dependent enzyme in the cupin superfamily and is found in fungi and soil bacteria. Oxalate decarboxylase catalyzes the decarboxylation of the oxalate mono-anion in the soil bacterium Bacillus subtilis. Enzymatic activity of OxDC is strongly pH dependent, with a maximum at around pH 4.0 .

HY-P99393

Tavolixizumab MEDI 0562; Tavolimab	TNF Receptor	Cancer
Tavolixizumab (MEDI 0562; Tavolimab) is a human monoclonal antibody to TNFRSF4 (TNF receptor superfamily member 4) for use in cancer immunology research .

HY-107404

SID 7969543	Orphan Nuclear Receptor	Endocrinology
SID 7969543 is a selective SF-1 (steroidogenic factor 1, NR5A1) inhibitor with an IC₅₀ of 760 nM. SID 7969543 inhibits SF-1-triggered luciferase expression with IC₅₀ of 30 nM. SF-1 is a transcription factor belonging to the nuclear receptor superfamily .

HY-145915A

(E/Z)-ZINC09659342	Ras	Cancer
(E/Z)-ZINC09659342 is an inhibitor of Lbc-RhoA interaction .

HY-D0091

7-Ethoxy-4-trifluoromethylcoumarin	Fluorescent Dye	Others
7-Ethoxy-4-trifluoromethylcoumarin is a fluorescent substrate of various enzymes of the cytochrome P450 superfamily

HY-145197

MPO-IN-3	Glutathione Peroxidase	Cardiovascular Disease
MPO-IN-3 is a potent myeloperoxidase (MPO) inhibitor (WO2013068875A1, example 191). Myeloperoxidase (MPO) is a heme-containing enzyme belonging to the peroxidase superfamily .

HY-P99945

Revdofilimab ABBV-368	Orexin Receptor (OX Receptor)	Inflammation/Immunology Cancer
Revdofilimab (ABBV-368) is a human IgG1 agonist monoclonal antibody against OX40. Among them, OX40 is a member of the TNF receptor superfamily expressed on activated and memory T cell subsets and T regulatory cells .

HY-P2961

Glutathione S-transferase	Glutathione S-transferase	Cancer
Glutathione S-transferase is a phase II metabolic enzyme consisting of three superfamilies: cytosolic, mitochondrial, and microsomal. Glutathione S-transferase possesses various catalytic activities such as catalytic detoxification and thiol transfer, as well as chaperone function. GSTP1, a subtype of Glutathione S-transferase, is highly expressed in malignant tissues and serves as a tumor marker .

HY-P99178

CTX-471	Interleukin Related	Inflammation/Immunology Cancer
CTX-471 is a fully human monoclonal antibody of CD137. CTX-471 has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with K_d values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 can be used for the research of immunomodulation and cancer .

HY-P2736

Amidase	Endogenous Metabolite	Metabolic Disease
Amidases, a member of nitrilase superfamily, catalyzes the hydrolysis of an amide, leading to the formation of carboxylic acid and ammonia. Amidases contain a conserved stretch of approximately 130 amino acids known as the AS sequence, and play a role in important metabolic processes .

HY-P3919

Adrenotensin (human) Pro-ADM-153-185 (human)	CGRP Receptor	Cardiovascular Disease
Adrenotensin (human) (Pro-ADM-153-185 (human)) is a 153-185 fragment of precursor peptide of Adrenomedullin. Adrenomedullin (ADM) is a 52-amino acid multifunctional peptide, which belongs to the CGRP superfamily of vasoactive peptide hormones .

HY-P10053

sPLA2-IIA Inhibitor	Phospholipase	Metabolic Disease
sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids .

HY-174485

OVA mRNA	mRNA	Others
OVA mRNA encodes the ovalbumin (OVA) protein, a member of the serpin superfamily and the predominant glycoprotein found in egg whites. It is a commonly used antigen for immunization and biochemical studies and is an established model allergen for airway hyper-responsiveness.

HY-P990720

Elritercept KER-050	TGF-beta/Smad	Inflammation/Immunology
Elritercept (KER-050) is a recombinant fusion protein comprising a modified activin receptor type IIA extracellular domain fused to a human IgG1 Fc. Elritercept inhibits activin A and other select TGF-β superfamily ligands .

HY-P3919A

Adrenotensin (human) TFA Pro-ADM-153-185 (human) TFA	CGRP Receptor	Cardiovascular Disease
Adrenotensin (human) (Pro-ADM-153-185 (human)) TFA is a 153-185 fragment of precursor peptide of Adrenomedullin. Adrenomedullin (ADM) TFA is a 52-amino acid multifunctional peptide, which belongs to the CGRP superfamily of vasoactive peptide hormones .

HY-170327

ZCL279 1 Publications Verification	Ras	Cancer
ZCL279 is a small molecule modulator (SMM) that inhibits Cdc42-intersectin (ITSN) interaction. ZCL279 can activate Cdc42 (a cytoplasmic small GTPase in the Ras superfamily) at lower concentrations (<10 μM) and significantly inhibit it at higher concentrations (<10 μM) .

HY-E70022

D-Mannose isomerase (PsMaSeAF)	Others	Others
D-Mannose isomerase (PsMaSeAF) is a carbohydrate isomerase catalyzing the reversible isomerization of d-mannose to d-fructose. D-Mannose isomerase (PsMaSeAF) belongs to the N-acylglucosamine 2-epimerase (AGE) superfamily along with AGE, cellobiose 2-epimerase (CE), and aldose-ketose isomerase (AKI) .

HY-P2812B

Phospholipase D, cabbage	Phospholipase	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Phospholipase D, cabbage is an enzyme of the phospholipase superfamily. Phospholipase D, cabbage is widely found in bacteria, yeast, plants, animals and viruses and is often used in biochemical research. Phospholipase D, cabbage can catalyze the hydrolysis of the phosphodiester bond of glycerophospholipids to produce phosphatidic acid and soluble choline. Phospholipase D, cabbage is involved in a variety of disease-related processes, including diabetes, atherosclerosis, obesity, tumorigenesis, immune response and neuroendocrine function .

HY-178211

SHY-867	Ras MEK ERK Akt	Cancer
SHY-867 is a pan RAS inhibitor. SHY-867 effectively prevents the binding of K-Ras proteins and other members of the Ras superfamily of small GTPases with EC₅₀ values of 0.5-3 μM. SHY-867 effectively inhibits the phosphorylation of MEK, ERK1/2, and AKT downstream of K-Ras. SHY-867 inhibits the formation of the Ras-GTP activity complex. SHY-867 can be used to the studies of pancreatic cancer and non-small cell lung cancer .

HY-174484

OVA mRNA (5moU)	mRNA	Others
OVA mRNA (5moU) encodes the ovalbumin (OVA) protein, a member of the serpin superfamily and the predominant glycoprotein found in egg whites. It is a commonly used antigen for immunization and biochemical studies and is an established model allergen for airway hyper-responsiveness.

HY-P11413

PAI-1	Ser/Thr Protease	Cardiovascular Disease
PAI-1 is a plasminogen activator inhibitor. PAI-1 is a member of the Ser Protease inhibitor superfamily with antiprotease activity. PAI-1 is the main physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators (PAs) .

HY-P991151

Opamtistomig	PD-1/PD-L1 TNF Receptor	Cancer
Opamtistomig is a humanized immunoglobulin (H-γ1-scFv-L-κ) dimer monoclonal antibody targeting human programmed death ligand 1 (PD-L1), CD274 and tumor necrosis factor receptor superfamily member 9 (TNFRSF9). Opamtistomig is promising for research of various solid tumors and hematological malignancies .

HY-143862

Pparδ agonist 7	PPAR	Metabolic Disease
Pparδ agonist 7 is a potent agonist of Pparδ. The peroxisome proliferator-activated receptor (PPAR) is a member of the intranuclear receptor transcription factor superfamily that plays a key role in the regulation of metabolic homeostasis, inflammation, cell growth and differentiation in vivo. Pparδ agonist 7 has the potential for the research of non-alcoholic fatty liver disease (NAFLD) (extracted from patent WO2019105234A1, compound TM4) .

HY-P11454

PSM-mec peptide	Bacterial	Infection
PSM-mec peptide is a peptide toxin belonging to the phenol-soluble modulin (PSM) superfamily. PSM-mec peptide is encoded by the psm-mec gene and associated with the methicillin resistance gene element (SCCmec). PSM-mec peptide has pro-inflammatory, cytolytic functions and the role of regulating the structure of biofilms. PSM-mec peptide can be mainly used for the pathogenic mechanism and drug resistance research of canine pseudo-intermediate Staphylococcus (S. pseudintermedius) related infections and zoonotic diseases .

HY-178194

SHY-855	Ras MEK ERK Akt	Cancer
SHY-855 is a pan RAS inhibitor. SHY-855 effectively prevents the binding of K-Ras proteins and other members of the Ras superfamily of small GTPases with IC₅₀ values of 0.3-5 μM. SHY-855 effectively inhibits the phosphorylation of MEK, ERK1/2, and AKT downstream of K-Ras. SHY-855 inhibits the formation of the Ras-GTP activity complex. SHY-855 can be used to the studies of pancreatic cancer and non-small cell lung cancer .

HY-174515

Human TNFRSF1B mRNA	mRNA	Cancer
Human TNFRSF1B mRNA encodes the human TNF receptor superfamily member 1B (TNFRSF1B) protein, a member of the TNF receptor superfamily.

HY-145915

ZINC09659342	Ras	Cancer
ZINC09659342 (compound 13) is an inhibitor of Lbc-RhoA interaction with an IC₅₀ of 3.6 μΜ .

HY-174514

Human TNFRSF4 mRNA	mRNA	Cancer
Human TNFRSF4 mRNA encodes the human TNF receptor superfamily member 4 (TNFRSF4) protein, a member of the TNF receptor superfamily. TNFRSF4 has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5.

HY-174513

Human TNFRSF8 mRNA	mRNA	Inflammation/Immunology
Human TNFRSF8 mRNA encodes the human TNF receptor superfamily member 8 (TNFRSF8) protein, a member of the TNF receptor superfamily. TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.

HY-174732

Human CSF3 mRNA	mRNA	Inflammation/Immunology
Human CSF3 mRNA encodes the human colony stimulating factor 3 (CSF3) protein, a member of the IL-6 superfamily of cytokines. CSF3 controls the production, differentiation, and function of granulocytes.

HY-174640

Human IL12RB1 mRNA	mRNA	Inflammation/Immunology
Human IL12RB1 mRNA encodes the human interleukin 12 receptor subunit beta 1 (IL12RB1) protein, a type I transmembrane protein that belongs to the hemopoietin receptor superfamily.

HY-174546

Human PECAM1 mRNA	mRNA	Inflammation/Immunology
Human PECAM1 mRNA encodes the human platelet and endothelial cell adhesion molecule 1 (PECAM1) protein, a member of the immunoglobulin superfamily. PECAM1 is likely involved in leukocyte migration, angiogenesis, and integrin activation.

HY-174533

Human TGFB2 mRNA	mRNA	Cancer
Human TGFB2 mRNA encodes the human transforming growth factor beta 2 (TGFB2) protein, a secreted ligand of the TGF-beta superfamily. TGFB2 has suppressive effects on interleukin-2 dependent T-cell growth.

HY-P991125

Cenzestotug YH-002	TNF Receptor	Inflammation/Immunology Cancer
Cenzestotug is a monoclonal antibody targeting human tumor necrosis factor receptor superfamily member 4 (TNFRSF4). Cenzestotug activates relevant immune cells by binding to TNFRSF4, exerting immunostimulatory and antitumor activities. Cenzestotug is promising for research of cancer immunotherapy .

HY-174735

Human CDH5 mRNA	mRNA	Cancer
Human CDH5 mRNA encodes the human cadherin 5 (CDH5) protein, a classical cadherin of the cadherin superfamily. CDH5 functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner. It plays a role in endothelial adherens junction assembly and maintenance.

HY-174668

Human HNF1B mRNA	mRNA	Metabolic Disease
Human HNF1B mRNA encodes the human HNF1 homeobox B (HNF1B) protein, a member of the homeodomain-containing superfamily of transcription factors. HNF1B has been shown to function in nephron development, and regulates development of the embryonic pancreas.

HY-174518

Human TNF mRNA	mRNA	Cancer
Human TNF mRNA encodes the human tumor necrosis factor (TNF) protein, a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. TNF is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.

HY-174540

Human SERPINA1 mRNA	mRNA	Cancer
Human SERPINA1 mRNA encodes the human serpin family A member 1 (SERPINA1) protein, a serine protease inhibitor belonging to the serpin superfamily. SERPINA1’s major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).

HY-174781

Human ACVRL1 mRNA	mRNA	Cancer
Human ACVRL1 mRNA encodes the human activin A receptor like type 1 (ACVRL1) protein. ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development.

HY-174512

Human TNFSF8 mRNA	mRNA	Cancer
Human TNFSF8 mRNA encodes the human TNF superfamily member 8 (TNFSF8) protein, a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF8 was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines.

Cat. No.	Product Name

HY-L018

TGF-beta/Smad Compound Library

413 compounds

The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc.

MCE designs a unique collection of 413 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.

HY-L008

JAK/STAT Compound Library

704 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 704 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

HY-L081

Phosphatase Inhibitor Library

175 compounds

Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc.

Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action.

MCE supplies a unique collection of 175 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.

HY-L038

Differentiation Inducing Compound Library

2,405 compounds

Stem cells, which are found in all multi-cellular organisms, can divide and differentiate into diverse special cell types and can self-renew to produce more stem cells. To be useful in therapy, stem cells must be converted into desired cell types as necessary which is called induced differentiation or directed differentiation. Understanding and using signaling pathways for differentiation is an important method in successful regenerative medicine. Small molecules or growth factors induce the conversion of stem cells into appropriate progenitor cells, which will later give rise to the desired cell type. There is a variety of signal molecules and molecular families that may affect the establishment of germ layers in vivo, such as fibroblast growth factors (FGFs); the wnt family or superfamily of transforming growth factors β (TGFβ) and bone morphogenetic proteins (BMP). Unfortunately, for now, a high cost of recombinant factors is likely to limit their use on a larger scale in medicine. The more promising technique focuses on the use of small molecules. These small molecules can be used for either activating or deactivating specific signaling pathways. They enhance reprogramming efficiency by creating cells that are compatible with the desired type of tissue. It is a cheaper and non-immunogenic method.

MCE Differentiation Inducing Compound Library contains a unique collection of 2,405 compounds that act on signaling pathways for differentiation. These compounds are potential stimulators for induced differentiation. This library is a useful tool for researching directed differentiation and regenerative medicine.

Cat. No.	Product Name	Target	Research Area

HY-P3919

Adrenotensin (human) Pro-ADM-153-185 (human)	CGRP Receptor	Cardiovascular Disease
Adrenotensin (human) (Pro-ADM-153-185 (human)) is a 153-185 fragment of precursor peptide of Adrenomedullin. Adrenomedullin (ADM) is a 52-amino acid multifunctional peptide, which belongs to the CGRP superfamily of vasoactive peptide hormones .

HY-P10053

sPLA2-IIA Inhibitor	Phospholipase	Metabolic Disease
sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids .

HY-P3919A

Adrenotensin (human) TFA Pro-ADM-153-185 (human) TFA	CGRP Receptor	Cardiovascular Disease
Adrenotensin (human) (Pro-ADM-153-185 (human)) TFA is a 153-185 fragment of precursor peptide of Adrenomedullin. Adrenomedullin (ADM) TFA is a 52-amino acid multifunctional peptide, which belongs to the CGRP superfamily of vasoactive peptide hormones .

HY-P11413

PAI-1	Ser/Thr Protease	Cardiovascular Disease
PAI-1 is a plasminogen activator inhibitor. PAI-1 is a member of the Ser Protease inhibitor superfamily with antiprotease activity. PAI-1 is the main physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators (PAs) .

HY-P11454

PSM-mec peptide	Bacterial	Infection
PSM-mec peptide is a peptide toxin belonging to the phenol-soluble modulin (PSM) superfamily. PSM-mec peptide is encoded by the psm-mec gene and associated with the methicillin resistance gene element (SCCmec). PSM-mec peptide has pro-inflammatory, cytolytic functions and the role of regulating the structure of biofilms. PSM-mec peptide can be mainly used for the pathogenic mechanism and drug resistance research of canine pseudo-intermediate Staphylococcus (S. pseudintermedius) related infections and zoonotic diseases .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99720

Luspatercept 5 Publications Verification ACE-536; luspatercept–aamt	TGF-beta/Smad	Metabolic Disease Cancer
Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia .

HY-P99590A

Sotatercept (mIgG2a) 1 Publications Verification RAP-011	TGF-β Receptor TGF-beta/Smad	Cardiovascular Disease Metabolic Disease
Sotatercept (mIgG2a) (RAP-011), the murine homolog of Sotatercept (ACE-011) (HY-P99590), is a soluble activin receptor type IIA (ActRIIA) ligand trap. Sotatercept (mIgG2a) inhibits the binding of activin A and other members of the TGF-β superfamily (such as Activin A/B, GDF11 and BMP9/10) to their receptors by combining and neutralizing them, thereby regulating cell proliferation and differentiation. Sotatercept (mIgG2a) mainly inhibits the SMAD2/3 signaling pathway, and can be used in various diseases such as chronic kidney disease. Sotatercept (mIgG2a) reduces the expression of erythropoietic hepcidin (ERFE), regulates iron metabolism, and promotes red blood cell production. Sotatercept (mIgG2a) has a dual effect of promoting bone formation (anabolic) and inhibiting bone resorption (catabolic) .

HY-P990070

Zigakibart BION-1301	TNF Receptor
Zigakibart (BION-1301) is an IgG4-kappa, humanized monoclonal antibody against TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256). Zigakibart exhibits anti-inflammatory activity .

HY-P99393

Tavolixizumab MEDI 0562; Tavolimab	TNF Receptor	Cancer
Tavolixizumab (MEDI 0562; Tavolimab) is a human monoclonal antibody to TNFRSF4 (TNF receptor superfamily member 4) for use in cancer immunology research .

HY-P99945

Revdofilimab ABBV-368	Orexin Receptor (OX Receptor)	Inflammation/Immunology Cancer
Revdofilimab (ABBV-368) is a human IgG1 agonist monoclonal antibody against OX40. Among them, OX40 is a member of the TNF receptor superfamily expressed on activated and memory T cell subsets and T regulatory cells .

HY-P99178

CTX-471	Interleukin Related	Inflammation/Immunology Cancer
CTX-471 is a fully human monoclonal antibody of CD137. CTX-471 has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with K_d values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 can be used for the research of immunomodulation and cancer .

HY-P990720

Elritercept KER-050	TGF-beta/Smad	Inflammation/Immunology
Elritercept (KER-050) is a recombinant fusion protein comprising a modified activin receptor type IIA extracellular domain fused to a human IgG1 Fc. Elritercept inhibits activin A and other select TGF-β superfamily ligands .

HY-P991151

Opamtistomig	PD-1/PD-L1 TNF Receptor	Cancer
Opamtistomig is a humanized immunoglobulin (H-γ1-scFv-L-κ) dimer monoclonal antibody targeting human programmed death ligand 1 (PD-L1), CD274 and tumor necrosis factor receptor superfamily member 9 (TNFRSF9). Opamtistomig is promising for research of various solid tumors and hematological malignancies .

HY-P991125

Cenzestotug YH-002	TNF Receptor	Inflammation/Immunology Cancer
Cenzestotug is a monoclonal antibody targeting human tumor necrosis factor receptor superfamily member 4 (TNFRSF4). Cenzestotug activates relevant immune cells by binding to TNFRSF4, exerting immunostimulatory and antitumor activities. Cenzestotug is promising for research of cancer immunotherapy .

HY-P991835

Anti-Mouse BTLA/CD272 Antibody (PJ196)	CD28	Inflammation/Immunology
Anti-Mouse BTLA/CD272 Antibody (PJ196) reacts with mouse B- and T-lymphocyte attenuator (BTLA). BTLA is an Ig superfamily member. Recommend Isotype Controls: Rat IgG2a kappa, Isotype Control (HY-P990679) .

HY-P991833

Anti-Mouse BTLA/CD272 Antibody (PK18.6)	CD28	Inflammation/Immunology
Anti-Mouse BTLA/CD272 Antibody (PK18.6) reacts with mouse B- and T-lymphocyte attenuator (BTLA). BTLA is an Ig superfamily member. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979) .

HY-P991847

Anti-PD-L2 Antibody (3.2)	PD-1/PD-L1	Cancer
Anti-PD-L2 Antibody (3.2) recognizes an epitope on mouse and human PD-L2. PD-L2 is a 25 kD type I transmembrane protein and a member of B7 family within the immunoglobulin receptor superfamily. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .

Host:	Mouse (22) Rabbit (35)
Reactivity:	Human (55) Rat (13) Mouse (15) human (2)
Application:	IHC-P (26) ICC/IF (19) mIHC (1) IF-Tissue (5) IP (10) IHC-F (3) WB (30) FC (21) ELISA (29)
Isotype:	IgG (36) IgG1 (12) IgG2a (1) IgG2b (2)
Conjugation:	Non-conjugated (58) Biotin (36)
Clonality:	Polyclonal (3) polyclonal (1) Monoclonal (38) Monoclonal Antibody (1) Recombinant (26)
Modification:	Unmodified (46)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P89673

	DnaJC3 Antibody (YA9017) P58IPK, PRKRI, DNAJC3, DnaJ homolog subfamily C member 3, Endoplasmic reticulum DNA J domain-containing protein 6, Protein kinase inhibitor of 58 kDa, ER-resident protein ERdj6, ERdj6, Protein kinase inhibitor p58	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human
	DnaJC3 Antibody (YA9017) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DnaJC3.

HY-P87474A

	CNTN4/AXCAM Antibody (YA7161) (PBS only) Contactin-4, Brain-derived immunoglobulin Superfamily protein 2, BIG-2, CNTN4	WB	Human
	CNTN4/AXCAM Antibody (YA7161)(PBS only) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CNTN4/AXCAM.

HY-P85305

	Osteoprotegerin Antibody (YA4997) TNFRSF11B; OCIF; OPG; Tumor necrosis factor receptor Superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin	IHC-P, IHC-F, ICC/IF, IF-Tissue	Human
	Osteoprotegerin Antibody (YA4997) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Osteoprotegerin.

HY-P85306

	Osteoprotegerin Antibody (YA4998) TNFRSF11B; OCIF; OPG; Tumor necrosis factor receptor Superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin	IHC-P, ELISA	Human
	Osteoprotegerin Antibody (YA4998) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Osteoprotegerin.

HY-P810502

	CD269/BCMA Antibody TNFRSF17, BCM, BCMA, Tumor necrosis factor receptor Superfamily member 17, B-cell maturation protein, CD269	WB, IHC-P	Human
	CD269/BCMA Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to CD269/BCMA.

HY-P810369

	B7H4 Antibody (YA9689) B7 family member, H4, B7 H4, B7 homolog 4, B7 Superfamily member 1, B7 Superfamily, member 1, B7-H4, B7h.5, B7h4, B7S1, B7x	WB, ICC/IF	Human, Mouse, Rat
	B7H4 Antibody (YA9689) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to B7H4.

HY-P85306A

	Osteoprotegerin Antibody (YA4998)(PBS only) TNFRSF11B; OCIF; OPG; Tumor necrosis factor receptor Superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin	IHC-P, ELISA	Human
	Osteoprotegerin Antibody (YA4998) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Osteoprotegerin.

HY-P80914

	TNF alpha Antibody 5 Publications Verification TNF; TNFA; TNFSF2; Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand Superfamily member 2; TNF-a	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	TNF alpha Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to TNF alpha.

HY-P81584

	4-1BBL Antibody (YA1329) TNFSF9; Tumor necrosis factor ligand Superfamily member 9; 4-1BB ligand; 4-1BBL	FC, ELISA	Human
	4-1BBL Antibody (YA1329) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 4-1BBL.

HY-P82571

	4-1BBL Antibody (YA2316) TNFSF9; Tumor necrosis factor ligand Superfamily member 9; 4-1BB ligand; 4-1BBL	WB, IP	Human
	4-1BBL Antibody (YA2316) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 4-1BBL.

HY-P84953

	4-1BBL Antibody (YA7076) TNFSF9; Tumor necrosis factor ligand Superfamily member 9; 4-1BB ligand; 4-1BBL	ELISA
	4-1BBL Antibody is a non-conjugated antibody, targeting to 4-1BBL/CD137L.

HY-P81756

	CD269/BCMA Antibody (YA1501) TNFRSF17; BCM; BCMA; Tumor necrosis factor receptor Superfamily member 17; B-cell maturation protein; CD269	ICC/IF, FC, IP, ELISA	Human
	CD269/BCMA Antibody (YA1501) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD269/BCMA.

HY-P89406

	TNFSF15 Antibody TL1, VEGI, TNFSF15, Tumor necrosis factor ligand Superfamily member 15, TNF ligand-related molecule 1, Vascular endothelial cell growth inhibitor	WB, IHC-P, mIHC	Human, Mouse, Rat

HY-P81123

	Osteoprotegerin Antibody (YA3535) MGC29565 antibody; OCIF antibody; OPG antibody; Osteoclastogenesis inhibitory factor antibody; Osteoprotegerin antibody; PDB5 antibody; TNF receptor Superfamily member 11b antibody; TNFRSF 11B antibody; TNFRSF11B antibody; TR 1 antibody; TR1 antibody; TR11B_HUMAN antibody; Tumor necrosis factor receptor Superfamily member 11B antibody;	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Osteoprotegerin Antibody (YA3535) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Osteoprotegerin.

HY-P86413

	TNF alpha Antibody (YA6105) TNF; TNFA; TNFSF2; Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand Superfamily member 2; TNF-a	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	TNF alpha Antibody (YA6105) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TNF alpha.

HY-P82571A

	4-1BBL Antibody (YA2316)(PBS only) TNFSF9; Tumor necrosis factor ligand Superfamily member 9; 4-1BB ligand; 4-1BBL	WB, IP	Human
	4-1BBL Antibody (YA2316) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 4-1BBL.

HY-P87395A

	TRAIL/CD253 Antibody (YA7083)(PBS only) CD253, Trail, Tnfsf10, Tumor necrosis factor ligand Superfamily member 10, TNF-related apoptosis-inducing ligand, Protein TRAIL	FC, ELISA	Human
	TRAIL/CD253 Antibody (YA7083) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRAIL/CD253.

HY-P87145

	VSIG4 Antibody (YA6838) Complement receptor of the immunoglobulin Superfamily antibody; CRIg antibody; Ig Superfamily protein antibody; Protein Z39Ig antibody; UNQ317/PRO362 antibody; V set and immunoglobulin domain containing 4 antibody; V-set and immunoglobulin domain-containing protein 4 antibody; VSIG4 antibody; VSIG4_HUMAN antibody; Z39IG antibody;	WB, IHC-P	Human
	VSIG4 Antibody (YA6838) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VSIG4.

HY-P87390

	CLEC4F Antibody (YA7073) C type (calcium dependent, carbohydrate recognition domain) lectin, Superfamily member 13 antibody; C-type lectin 13 antibody; C-type lectin domain family 4 member F antibody; C-type lectin Superfamily member 13 antibody; CLC4F_HUMAN antibody; Clec4f antibody; CLECSF13 antibody; KCLR antibody	WB, FC	Human
	CLEC4F Antibody (YA7073) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CLEC4F.

HY-P89994

	CTMP Antibody (YA9338) CTMP, THEM4, Acyl-coenzyme A thioesterase THEM4, Acyl-CoA thioesterase THEM4, Carboxyl-terminal modulator protein, Thioesterase Superfamily member 4	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human
	CTMP Antibody (YA9338) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CTMP.

HY-P83589

	Lymphotoxin alpha Antibody (YA3334) LTalpha; DIF; LT alpha; Lta; Lymphotoxin alpha; TNF B; TNF Superfamily member 1; TNF-beta; TNFB; TNFbeta; TNFSF1; TNLG1E	WB	Human
	Lymphotoxin alpha Antibody (YA3334) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lymphotoxin alpha.

HY-P80056

	CD40 Antibody (YA805) CD40, TNFRSF5, Tumor necrosis factor receptor Superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40	WB, ICC/IF, IHC-P	Human
	CD40 Antibody (YA805) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD40.

HY-P84980

	CD269/BCMA Antibody (YA4672) TNFRSF17; BCM; BCMA; Tumor necrosis factor receptor Superfamily member 17; B-cell maturation protein; CD269; CD269 nanobody; BCMA nanobody;	FC, ELISA	Human
	CD269/BCMA Antibody (YA4672) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD269/BCMA.

HY-P810692

	TNFSF12 Antibody TNFSF12; APO3L; DR3LG; Tumor necrosis factor ligand Superfamily member 12; APO3 ligand; TNF-related weak inducer of apoptosis; TWEAK	WB, IHC-P, ICC/IF, ELISA	Human, Mouse
	TNFSF12 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to TNFSF12.

HY-P83029

	p75 NGF Receptor Antibody (YA2774) CD271 antibody; CD271 antigen antibody; Gp80 LNGFR antibody; Gp80-LNGFR antibody; Low affinity nerve growth factor receptor antibody; Low affinity neurotrophin receptor p75NTR antibody; Low-affinity nerve growth factor receptor antibody; Nerve growth factor receptor antibody; Nerve growth factor receptor TNFR Superfamily member 16 antibody; NGF receptor antibody; Ngfr antibody; p75 ICD antibody; p75 Neurotrophin receptor antibody; p75 NTR antibody; p75(NTR) antibody; p75NTR antibody; TNFR Superfamily Member 16 antibody; TNFRSF16 antibody; TNR16_HUMAN antibody; Tumor necrosis factor receptor Superfamily member 16 antibody;	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	p75 NGF Receptor Antibody (YA2774) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p75 NGF Receptor.

HY-P81762

	TNFSF12 Antibody (YA1507) TNFSF12; APO3L; DR3LG; Tumor necrosis factor ligand Superfamily member 12; APO3 ligand; TNF-related weak inducer of apoptosis; TWEAK	FC, ELISA	Human
	TNFSF12 Antibody (YA1507) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TNFSF12.

HY-P83029A

	p75 NGF Receptor Antibody (YA2774)(PBS only) CD271 antibody; CD271 antigen antibody; Gp80 LNGFR antibody; Gp80-LNGFR antibody; Low affinity nerve growth factor receptor antibody; Low affinity neurotrophin receptor p75NTR antibody; Low-affinity nerve growth factor receptor antibody; Nerve growth factor receptor antibody; Nerve growth factor receptor TNFR Superfamily member 16 antibody; NGF receptor antibody; Ngfr antibody; p75 ICD antibody; p75 Neurotrophin receptor antibody; p75 NTR antibody; p75(NTR) antibody; p75NTR antibody; TNFR Superfamily Member 16 antibody; TNFRSF16 antibody; TNR16_HUMAN antibody; Tumor necrosis factor receptor Superfamily member 16 antibody;	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	p75 NGF Receptor Antibody (YA2774) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p75 NGF Receptor.

HY-P86549

	Fas Antibody (YA6241) FAS; APT1; FAS1; TNFRSF6; Tumor necrosis factor receptor Superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; CD antigen CD95	WB, IHC-P, ICC/IF, IP, ELISA	Human
	Fas Antibody (YA6241) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Fas.

HY-P85090

	CD40 Antibody (YA4782) CD40; TNFRSF5; Tumor necrosis factor receptor Superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD antigen CD40	ICC/IF, ELISA	Human
	CD40 Antibody (YA4782) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD40.

HY-P85832

	CD40 Antibody (YA5524) CD40; TNFRSF5; Tumor necrosis factor receptor Superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD antigen CD40	FC, ELISA	Human
	CD40 Antibody (YA5524) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD40.

HY-P87432A

	CD101 Antibody (YA7120)(PBS only) CD101, EWI101, IGSF2, V7, Immunoglobulin Superfamily member 2, IgSF2, Cell surface glycoprotein V7, Glu-Trp-Ile EWI motif-containing protein 101, EWI-101	FC, ELISA	Human
	CD101 Antibody (YA7120) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD101.

HY-P82712

	ALK-1 Antibody (YA2457) ACVRL1; ACVRLK1; ALK1; Serine/threonine-protein kinase receptor R3; SKR3; Activin receptor-like kinase 1; ALK-1; TGF-B Superfamily receptor type I; TSR-I	WB	Human, Mouse, Rat
	ALK-1 Antibody (YA2457) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ALK-1.

HY-P84961

	CD134/OX40L Recepter Antibody (YA4653) ACT 35 antibody; ATC35 antigen antibody; CD134 antibody; IMD16 antibody; Lymphoid activation antigene ACT35 antibody; OX40 antibody; OX40L receptor antibody; TAX transcriptionally activated glycoprotein 1 receptor antibody; TNF receptor Superfamily member 4 antibody; TNFRSF 4 antibody; TNR4_HUMAN antibody; Tumor necrosis factor receptor Superfamily member 4 antibody; Txgp 1l antibody; Txgp1 antibody	WB, ICC/IF, IP, FC	Human
	CD134/OX40L Recepter Antibody (YA4653) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD134/OX40L Recepter.

HY-P87424A

	EDA2R/XEDAR Antibody (YA7112)(PBS only) TNFRSF27, XEDAR, UNQ2448/PRO5727/PRO34080, EDA2R, Tumor necrosis factor receptor Superfamily member 27, X-linked ectodysplasin-A2 receptor, EDA-A2 receptor	FC, ELISA	Human
	EDA2R/XEDAR Antibody (YA7112) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to EDA2R/XEDAR.

HY-P81730

	OX40L Antibody (YA1475) TNFSF4; TXGP1; Tumor necrosis factor ligand Superfamily member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; CD antigen CD252	FC, ELISA	Human
	OX40L Antibody (YA1475) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to OX40L.

HY-P85005

	CD70 Antibody (YA4697) CD70; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27 ligand; CD27-L; Tumor necrosis factor ligand Superfamily member 7; CD antigen CD70; CD70 nanobody;	ELISA, FC	Human
	CD70 Antibody (YA4697) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD70.

HY-P87407A

	TNFRSF6B/DcR3 Antibody (YA7095)(PBS only) DCR3, TR6, UNQ186/PRO212, TNFRSF6B, Tumor necrosis factor receptor Superfamily member 6B, Decoy receptor 3, Decoy receptor for Fas ligand, M68, DcR3	FC, ELISA	Human
	TNFRSF6B/DcR3 Antibody (YA7095) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TNFRSF6B/DcR3.

HY-P87428A

	CLEC10A/CD301 Antibody (YA7116)(PBS only) CD301, CLECSF13, CLECSF14, HML, CLEC10A, C-type lectin domain family 10 member A, C-type lectin Superfamily member 14, Macrophage lectin 2	FC, ELISA	Human
	CLEC10A/CD301 Antibody (YA7116) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CLEC10A/CD301.

HY-P81759

	CD134/OX40L Recepter Antibody (YA1504) TNFRSF4; TXGP1L; Tumor necrosis factor receptor Superfamily member 4; ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; CD antigen CD134	FC, ELISA	Human
	CD134/OX40L Recepter Antibody (YA1504) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD134/OX40L Recepter.

HY-P85296

	NGFR p75 Antibody (YA4988) NGFR; TNFRSF16; Tumor necrosis factor receptor Superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD antigen CD271	IHC-P, IHC-F, ICC/IF, IF-Tissue	Human, Rat, Mouse
	NGFR p75 Antibody (YA4988) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to NGFR p75.

HY-P81500

	p75 NGF Receptor Antibody (YA1245) NGFR; TNFRSF16; Tumor necrosis factor receptor Superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD antigen CD271	IHC-P	Human
	p75 NGF Receptor Antibody (YA1245) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p75 NGF Receptor.

HY-P84962

	CD137/4-1BB Antibody (YA4654) TNFRSF9; CD137; ILA; Tumor necrosis factor receptor Superfamily member 9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CD antigen CD137	ELISA	Human
	CD137/4-1BB Antibody (YA4654) is a non-conjugated antibody, targeting to CD137/4-1BB.

HY-P87404A

	DR4/TNFRSF10A Antibody (YA7092)(PBS only) CD261, APO2, DR4, TRAILR1, TNFRSF10A, Tumor necrosis factor receptor Superfamily member 10A, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1	WB, ICC/IF, FC	Human
	DR4/TNFRSF10A Antibody (YA7092) is a Rabbit-derived and non-conjugated IgG Recombinant monoclonal antibody, targeting to DR4/TNFRSF10A.

HY-P85515

	Fas(C-term) Antibody (YA5207) ALPS 1A; ALPS1A; APO 1; Apo 1 antigen; APO 1 cell surface antigen; Apo-1 antigen; APO1; Apo1 antigen; APO1 cell surface antigen; Apoptosis antigen 1; Apoptosis mediating surface antigen FAS; Apoptosis-mediating surface antigen FAS; APT 1; APT1; CD 95; CD 95 antigen; CD95; CD95 antigen; Delta Fas; Delta Fas/APO 1/CD95; Delta Fas/APO1/CD95; Fas; TNF receptor Superfamily, member 6; FAS 1; FAS 827dupA; Fas AMA; FAS; FAS Antigen; Fas cell surface death receptor; FAS1; FASLG receptor; FASTM; sFAS; Surface antigen APO1; TNF receptor Superfamily, member 6; TNFRSF 6; TNFRSF6; TNR6_HUMAN; Tumor necrosis factor receptor Superfamily member 6.	WB	Human
	Fas(C-term) Antibody (YA5207) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Fas(C-term).

HY-P81500A

	p75 NGF Receptor Antibody (YA1245)(PBS only) NGFR; TNFRSF16; Tumor necrosis factor receptor Superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD antigen CD271	IHC-P	Human
	p75 NGF Receptor Antibody (YA1245) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p75 NGF Receptor.

HY-P81124

	RANKL Antibody OPGL; CD254; hRANKL2; ODF; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; RANKL; Receptor activator of nuclear factor kappa B ligand; sOdf; SOFA; TNF related activation induced cytokine; TNFSF 11; TNFSF11; TRANCE; Tumor necrosis factor ligand Superfamily member 11; Osteoprotegerin Ligand; TNF11_HUMAN.	WB, IHC-P, ELISA	Human, Mouse, Rat
	RANKL Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to RANKL.

HY-P87435A

	CD300C Antibody (YA7123)(PBS only) CD300c, CMRF35, CMRF35A, CMRF35A1, IGSF16, CD300C, CMRF35-like molecule 6, CLM-6, CD300 antigen-like family member C, CMRF35-A1, Immunoglobulin Superfamily member 16, CMRF-35, IgSF16	FC, ELISA	Human
	CD300C Antibody (YA7123) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CD300C.

HY-P82843

	DcR2 Antibody (YA2588) TNFRSF10D; DCR2; TRAILR4; TRUNDD; Tumor necrosis factor receptor Superfamily member 10D; Decoy receptor 2; DcR2; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL-R4; TRAIL receptor with a truncated death domain; CD	WB, IHC-P, ICC/IF	Human
	DcR2 Antibody (YA2588) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DcR2.

HY-P86995

	Nectin-4 Antibody (YA6688) DKFZp686K05193 antibody; EDSS1 antibody; Ig Superfamily receptor LNIR antibody; Nectin 4 antibody; Nectin-4 antibody; poliovirus receptor-related 4 antibody; Processed poliovirus receptor-related protein 4 antibody; PRR4 antibody; pvrl4 antibody; PVRL4_HUMAN antibody;	WB, IHC-P	Human
	Nectin-4 Antibody (YA6688) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nectin-4.

HY-P81429

	CLEC4C Antibody (YA1174) CLEC4C; BDCA2, CLECSF11, CLECSF7, DLEC, HECL; UNQ9361/PRO34150; C-type lectin domain family 4 member C; CD303; Blood dendritic cell antigen 2 (BDCA-2); C-type lectin Superfamily member 7; Dendritic lectin	IHC-P	Human
	CLEC4C Antibody (YA1174) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLEC4C.

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Cat. No.	Product Name		Classification

HY-107823

Cholesteryl acetate Cholesterol 3-acetate; Cholesterin acetate; Cholesterol 3β-acetate		Cholesterol
Cholesteryl acetate (Cholesterol 3-acetate) is a cholesterol ester that is exported from Saccharomyces cerevisiae via a Pry1-dependent mechanism. Cholesteryl acetate binds to the CAP superfamily protein Pry1 via interactions dependent on Pry1’s caveolin-binding motif .

HY-174485

OVA mRNA		mRNA Antigens
OVA mRNA encodes the ovalbumin (OVA) protein, a member of the serpin superfamily and the predominant glycoprotein found in egg whites. It is a commonly used antigen for immunization and biochemical studies and is an established model allergen for airway hyper-responsiveness.

HY-174484

OVA mRNA (5moU)		mRNA Antigens
OVA mRNA (5moU) encodes the ovalbumin (OVA) protein, a member of the serpin superfamily and the predominant glycoprotein found in egg whites. It is a commonly used antigen for immunization and biochemical studies and is an established model allergen for airway hyper-responsiveness.

HY-174515

Human TNFRSF1B mRNA		mRNA
Human TNFRSF1B mRNA encodes the human TNF receptor superfamily member 1B (TNFRSF1B) protein, a member of the TNF receptor superfamily.

HY-174514

Human TNFRSF4 mRNA		mRNA
Human TNFRSF4 mRNA encodes the human TNF receptor superfamily member 4 (TNFRSF4) protein, a member of the TNF receptor superfamily. TNFRSF4 has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5.

HY-174513

Human TNFRSF8 mRNA		mRNA
Human TNFRSF8 mRNA encodes the human TNF receptor superfamily member 8 (TNFRSF8) protein, a member of the TNF receptor superfamily. TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.

HY-174732

Human CSF3 mRNA		mRNA
Human CSF3 mRNA encodes the human colony stimulating factor 3 (CSF3) protein, a member of the IL-6 superfamily of cytokines. CSF3 controls the production, differentiation, and function of granulocytes.

HY-174640

Human IL12RB1 mRNA		mRNA Interleukin & Receptors
Human IL12RB1 mRNA encodes the human interleukin 12 receptor subunit beta 1 (IL12RB1) protein, a type I transmembrane protein that belongs to the hemopoietin receptor superfamily.

HY-174546

Human PECAM1 mRNA		mRNA
Human PECAM1 mRNA encodes the human platelet and endothelial cell adhesion molecule 1 (PECAM1) protein, a member of the immunoglobulin superfamily. PECAM1 is likely involved in leukocyte migration, angiogenesis, and integrin activation.

HY-174533

Human TGFB2 mRNA		mRNA
Human TGFB2 mRNA encodes the human transforming growth factor beta 2 (TGFB2) protein, a secreted ligand of the TGF-beta superfamily. TGFB2 has suppressive effects on interleukin-2 dependent T-cell growth.

HY-174735

Human CDH5 mRNA		mRNA
Human CDH5 mRNA encodes the human cadherin 5 (CDH5) protein, a classical cadherin of the cadherin superfamily. CDH5 functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner. It plays a role in endothelial adherens junction assembly and maintenance.

HY-174668

Human HNF1B mRNA		mRNA Transcription Factors
Human HNF1B mRNA encodes the human HNF1 homeobox B (HNF1B) protein, a member of the homeodomain-containing superfamily of transcription factors. HNF1B has been shown to function in nephron development, and regulates development of the embryonic pancreas.

HY-174518

Human TNF mRNA		mRNA
Human TNF mRNA encodes the human tumor necrosis factor (TNF) protein, a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. TNF is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.

HY-174540

Human SERPINA1 mRNA		mRNA
Human SERPINA1 mRNA encodes the human serpin family A member 1 (SERPINA1) protein, a serine protease inhibitor belonging to the serpin superfamily. SERPINA1’s major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).

HY-174781

Human ACVRL1 mRNA		mRNA
Human ACVRL1 mRNA encodes the human activin A receptor like type 1 (ACVRL1) protein. ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development.

HY-174512

Human TNFSF8 mRNA		mRNA
Human TNFSF8 mRNA encodes the human TNF superfamily member 8 (TNFSF8) protein, a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF8 was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines.

HY-174534

Human TGFB1 mRNA		mRNA
Human TGFB1 mRNA encodes the human transforming growth factor beta 1 (TGFB1) protein, a secreted ligand of the TGF-beta superfamily. TGFB1 can regulate cell proliferation, differentiation and growth, and also play a role in modulating expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha.

HY-174738

Human CD40 mRNA		mRNA
Human CD40 mRNA encodes the human CD40 molecule (CD40) protein, a member of the TNF-receptor superfamily. CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.

HY-174713

Human FASLG mRNA		mRNA
Human FASLG mRNA encodes the human Fas ligand (FASLG) protein, a member of the tumor necrosis factor superfamily. The primary function of the FASLG is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers.

HY-174529

Human TGFBR3 mRNA		mRNA
Human TGFBR3 mRNA encodes the human transforming growth factor beta receptor 3 (TGFBR3) protein, a transforming growth factor (TGF)-beta type III receptor. TGFBR3 is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers.

HY-174516

Human TNFRSF1A mRNA		mRNA
Human TNFRSF1A mRNA encodes the human TNF receptor superfamily member 1A (TNFRSF1A) protein, a member of the TNF receptor superfamily.

HY-174517

Human TNFRSF14 mRNA		mRNA
Human TNFRSF14 mRNA encodes the human TNF receptor superfamily member 14 (TNFRSF14) protein, a member of the TNF receptor superfamily. TNFRSF14 functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells.

HY-174532

Human TGFB3 mRNA		mRNA
Human TGFB3 mRNA encodes the human transforming growth factor beta 3 (TGFB3) protein, a secreted ligand of the TGF-beta superfamily. TGFB3 is involved in embryogenesis and cell differentiation, and may play a role in wound healing.

HY-174586

Human LTBR mRNA		mRNA
Human LTBR mRNA encodes the human lymphotoxin beta receptor (LTBR) protein, a member of the tumor necrosis factor receptor superfamily. LTBR plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death.

HY-174714

Human FAS mRNA		mRNA
Human FAS mRNA encodes the human Fas cell surface death receptor (FAS) protein, a member of the TNF-receptor superfamily. FAS has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system.

HY-174774

Human BMPR1B mRNA		mRNA
Human BMPR1B mRNA encodes the human bone morphogenetic protein receptor type 1B (BMPR1B) protein, a family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis.

HY-174721

Human EGFR mRNA		mRNA
Human EGFR mRNA encodes the human epidermal growth factor receptor (EGFR) protein, a member of the protein kinase superfamily. IGF1R plays a critical role in transformation events. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation.

HY-185002

BCMA CAR mRNA		mRNA CAR-T
BCMA CAR mRNA can express the CAR protein targeting human BCMA. BCMA CAR mRNA can trigger the transient expression of CAR, enabling T cells to be targeted without the need for permanent genetic modification. BCMA is a member of the tumor necrosis factor receptor superfamily 17 (TNFRSF17), also known as B-cell maturation antigen (CD269), which promotes B-cell survival and plays a role in regulating humoral immunity. BCMA is highly expressed in multiple myeloma and is a biomarker for the diagnosis of multiple myeloma.

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