2. Search Result
Search Result
Results for "

IRAK4 protein

" in MedChemExpress (MCE) Product Catalog:

17

阻害剤およびアゴニスト

6

組換えタンパク質

Targets Recommended:
製品番号 製品名 Target 研究分野 構造式
  • HY-103490
    Takinib
    25+ Cited Publications

    EDHS-206

    		 MAP3K Apoptosis Infection Inflammation/Immunology Cancer
    Takinib (EDHS-206) is an orally active and selective TAK1 inhibitor (IC50=9.5 nM), more than 1.5 log more potent than the second and third ranked targets, IRAK4 (120 nM) and IRAK1 (390 nM), respectively. Takinib is an inhibitor of autophosphorylated TAK1 that non-competitively binds within the ATP binding pocket. Takinib induces apoptosis following TNFα stimulation in cell models of rheumatoid arthritis and metastatic breast cancer. Takinib is also a P. falciparum protein kinase 9 (PfPK9) inhibitor (KD(app) of 0.46 μM) .
    Takinib
  • HY-153368
    Zomiradomide

    KT-413

    		 PROTACs IRAK NF-κB IFNAR Cancer
    Zomiradomide is an orally active PROTAC degrader for IRAK4 (DC50=6 nM), thereby inhibiting the NF-κB signaling pathway. Zomiradomide acts also as a molecular glue, recruiting Ikaros and Aiolos, and mediating their degradation (DC50 for Ikaros is 1 nM), thereby activating the type I IFN signaling pathway . (Pink: target protein ligand PROTAC IRAK4 ligand-5 (HY-168311), Blue: E3 ligase ligand Thalidomide-4-Br (HY-W039116), Black: linker (HY-168313))
    Zomiradomide
  • HY-41547
    Thalidomide 4-fluoride

    Cereblon ligand 4; E3 ligase Ligand 4

    		 Ligands for E3 Ligase Autophagy Apoptosis Cancer
    Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966) .
    Thalidomide 4-fluoride
  • HY-139374
    Zabedosertib
    2 Publications Verification

    BAY 1834845

    		 IRAK Inflammation/Immunology
    Zabedosertib (BAY 1834845) is a selective, orally active IRAK4 inhibitor with immunomodulatory potential, IC50 is 3.55 nM. IRAK4 is a protein kinase involved in signaling innate immune responses from Toll-like receptors . Zabedosertib exhibits anti-inflammatory property against IL-β, LPS (HY-D1056) and Imiquimod (HY-B1080) induced inflammation .
    Zabedosertib
  • HY-W087383
    Thalidomide 5-fluoride

    		Ligands for E3 Ligase Autophagy Apoptosis Cancer
    Thalidomide 5-fluoride is a thalidomide-based Cereblon ligand used to recruit Cereblon protein. Thalidomide 5-fluoride can be linked to target protein ligands (e.g. IRAK4) through a linker to form PROTAC molecules (e.g. PROTAC IRAK4 degrader-1). PROTAC IRAK4 degrader-1 caused <20%, >20-50%, and >50% IRAK4 protein degradation in OCI-LY-10 cells at concentrations of 0.01, 0.1, and 1 μM, respectively .
    Thalidomide 5-fluoride
  • HY-153188
    JNJ-1013

    		PROTACs Apoptosis IRAK Cancer
    JNJ-1013 is a potent and selective IRAK1 PROTAC degrader with an IC50s of 72, 443, 1071 nM for IRAK1, IRAK4, VHL FP respectively. JNJ-1013 induces apoptosis and increases the expression of cleavaged PARP. JNJ-1013 decreases the expression IRAK1, p-IKBα, pSTAT3(Tyr705) (Pink: ligand for target protein (HY-138834); black: linker (HY-Y1760); Blue: E3 ligase ligand (HY-112078)) .
    JNJ-1013
  • HY-77048
    IRAK-4 protein kinase inhibitor 2

    		IRAK Inflammation/Immunology
    IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC50 of 4 μM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disorders .
    IRAK-4 protein kinase inhibitor 2
  • HY-145484
    PROTAC IRAK4 ligand-3

    		Ligands for Target Protein for PROTAC IRAK Cancer
    PROTAC IRAK4 ligand-3 is a ligand for target protein for PROTAC, targeting IRAK4, can be used for synthesis of PROTAC KT-474 (HY-145483). PROTAC IRAK4 ligand-3 can be used in cancer research .
    PROTAC IRAK4 ligand-3
  • HY-E70731
    IRAK4 aa104-460 Recombinant Human Active Protein Kinase

    		IRAK Inflammation/Immunology
    The IRAK4 protein is a serine/threonine protein kinase that is critical for initiating the innate immune response through the Toll-like receptor (TLR) and IL-1R signaling pathways. After TLR is activated, it rapidly forms the Myddosome with IRAK2. IRAK4 aa104-460 Recombinant Human Active Protein Kinase is a recombinant IRAK4 aa104-460 protein that can be used to study IRAK4 aa104-460-related functions .
    IRAK4 aa104-460 Recombinant Human Active Protein Kinase
  • HY-135382
    PROTAC IRAK4 degrader-2

    		PROTACs IRAK Inflammation/Immunology Cancer
    PROTAC IRAK4 degrader-2 (Compound 9) is a PROTAC-based IRAK4 degrader that affords potent IRAK4 degradation with a DC50 in peripheral blood mononuclear cells (PBMCs) cells of 151 nM. PROTAC IRAK4 degrader-2 induce a reduction of IRAK4 protein levels with a DC50 of 36 nM in PBMC cells. PROTAC IRAK4 degrader-2 also leads to the inhibition of multiple cytokines in PBMCs .
    PROTAC IRAK4 degrader-2
  • HY-179095
    UR241-2

    		Ligands for Target Protein for PROTAC IRAK NF-κB p38 MAPK Cancer
    UR241-2 is an IRAK4 inhibitor. UR241-2 suppresses IL-1–induced IRAK1/4 signaling, NF-κβ activation, and phosphorylation of p65 and p38. UR241-2 selectively inhibits leukemia stem cell clonogenicity. UR241-2 can serve as a ligand for target proteins for PROTAC, facilitating the development and design of PROTAC degraders for IRAK4. UR241-2 can be used in the research of acute myeloid leukemia .
    UR241-2
  • HY-168611
    PROTAC IRAK4 ligand-4

    		Ligands for Target Protein for PROTAC IRAK Cancer
    PROTAC IRAK4 ligand-4 is a Ligand for Target Protein for PROTAC with antitumor activity. PROTAC IRAK4 ligand-4 can be used to synthesize PROTAC IRAK4 degrader-12 (HY-168586) .
    PROTAC IRAK4 ligand-4
  • HY-148275
    KTX-955

    		PROTACs IRAK Cancer
    KTX-955 is an antumor and effective IRAK4 degrader, with DC50 values of 5 nM and 130 nM for IRAK4 and Ikaros, respectively . KTX-955 is composed of CRBN ligand (blue part) Pomalidomide (HY-10984) and target protein ligand (red part) IRAK4-IN-20 (HY-150735).
    KTX-955
  • HY-172591
    IRAK4 ligand-13

    		IRAK Ligands for Target Protein for PROTAC
    IRAK4 ligand-13 is a IRAK4 ligand. IRAK4 ligand-13 is a ligand for Target Protein for PROTAC. IRAK4 ligand-13 can be used for synthesis of PROTACs, such as LZ-07 (HY-172591) .
    IRAK4 ligand-13
  • HY-48932
    IRAK4 ligand-12

    		Ligands for Target Protein for PROTAC Cancer
    IRAK4 ligand-12 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). IRAK4 ligand-12 can be used for the synthesis of KTX-951 (HY-148290) .
    IRAK4 ligand-12
  • HY-168311
    PROTAC IRAK4 ligand-5

    		Ligands for Target Protein for PROTAC Cancer
    PROTAC IRAK4 ligand-5 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PROTAC IRAK4 ligand-5 can be utilized for the synthesis of KT-413 (HY-153368) .
    PROTAC IRAK4 ligand-5
  • HY-103490R
    Takinib (Standard)

    EDHS-206 (Standard)

    		 Reference Standards MAP3K Apoptosis Infection Inflammation/Immunology Cancer
    Takinib (Standard) is the analytical standard of Takinib. This product is intended for research and analytical applications. Takinib (EDHS-206) is an orally active and selective TAK1 inhibitor (IC50=9.5 nM), more than 1.5 log more potent than the second and third ranked targets, IRAK4 (120 nM) and IRAK1 (390 nM), respectively. Takinib is an inhibitor of autophosphorylated TAK1 that non-competitively binds within the ATP binding pocket. Takinib induces apoptosis following TNFα stimulation in cell models of rheumatoid arthritis and metastatic breast cancer. Takinib is also a P. falciparum protein kinase 9 (PfPK9) inhibitor (KD(app) of 0.46 μM) .
    Takinib (Standard)

オンラインお問い合わせ

入力情報は安全に管理されます. ※ 必須入力項目.

タイトル

  

国或いは地域 *

お名前 *

 

組纖名 *

デパートメント *

     

メールアドレス *

 

製品名 *

製品番号

  

カスタマ需要量 *

電話番号 *

     

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
製品番号:
数量:
MCE 日本正規代理店: