Search Result

Pathways Recommended:	Membrane Transporter/Ion Channel

Results for "

Kv channels

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenylate Cyclase (2) Akt (1) Amyloid-β (2) Apoptosis (2) Biochemical Assay Reagents (2) Calcium Channel (11) Cholinesterase (ChE) (2) Cytochrome P450 (4) DNA/RNA Synthesis (7) Endogenous Metabolite (1) GABA Receptor (7) HCN Channel (2) iGluR (7) IKK (2) Interleukin Related (2) Isotope-Labeled Compounds (5) JNK (2) mAChR (5) MMP (1) NF-κB (2) NO Synthase (1) NOD-like Receptor (NLR) (4) Opioid Receptor (1) p38 MAPK (1) Parasite (7) Potassium Channel (157) Reference Standards (22) Ser/Thr Protease (1) Sigma Receptor (1) Sodium Channel (17) Tau Protein (2) TGF-beta/Smad (7) TRP Channel (4)
By Research Areas:	Cancer (19) Cardiovascular Disease (29) Endocrinology (1) Infection (7) Inflammation/Immunology (54) Metabolic Disease (5) Neurological Disease (112)

By Targets:

Adenylate Cyclase (2)

Akt (1)

Amyloid-β (2)

Apoptosis (2)

Biochemical Assay Reagents (2)

Calcium Channel (11)

Cholinesterase (ChE) (2)

Cytochrome P450 (4)

DNA/RNA Synthesis (7)

Endogenous Metabolite (1)

GABA Receptor (7)

HCN Channel (2)

iGluR (7)

IKK (2)

Interleukin Related (2)

Isotope-Labeled Compounds (5)

JNK (2)

mAChR (5)

MMP (1)

NF-κB (2)

NO Synthase (1)

NOD-like Receptor (NLR) (4)

Opioid Receptor (1)

p38 MAPK (1)

Parasite (7)

Potassium Channel (157)

Reference Standards (22)

Ser/Thr Protease (1)

Sigma Receptor (1)

Sodium Channel (17)

Tau Protein (2)

TGF-beta/Smad (7)

TRP Channel (4)

By Research Areas:

Cancer (19)

Cardiovascular Disease (29)

Endocrinology (1)

Infection (7)

Inflammation/Immunology (54)

Metabolic Disease (5)

Neurological Disease (112)

179

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139791

Azetukalner XEN1101	Potassium Channel	Neurological Disease
Azetukalner (XEN1101) is a selective and orally active **Kv7.2/Kv7.3 potassium channel opener with an EC₅₀** of 27 nM. Azetukalner is approximately 4-fold more selective for Kv7.2/7.3 over Kv7.3/7.5 (EC₅₀ of 94 nM) and Kv7.4 (EC₅₀ of 113 nM) channels. Azetukalner exhibits a selectivity >100-fold for Kv7 channels over other ion channels and receptors. Azetukalner can be used for the study of focal epilepsy .

HY-B0267

Oxybutynin	mAChR Potassium Channel	Neurological Disease Cancer
Oxybutynin is an anticholinergic agent, which inhibits vascular K_v channels in a concentration-dependent manner, with an IC₅₀ of 11.51 μM . Oxybutynin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-50722

NNC 55-0396 5 Publications Verification NNC 55-0396 dihydrochloride	Calcium Channel Cytochrome P450	Cardiovascular Disease Neurological Disease Cancer
NNC 55-0396 (NNC 55-0396 dihydrochloride) is a blood-brain-barrier-permeable T-type Ca ²⁺ channel inhibitor and pan-P450 inhibitor. NNC 55-0396 selectively inhibits T-type Ca ²⁺ channels, suppresses HIF-1α expression and stability and inhibits Kv currents. NNC 55-0396 reduces brain infarct and attenuates neurological dysfunction. NNC 55-0396 inhibits the activity of multiple P450 enzymes. NNC 55-0396 (free base) can be used for the research of brain injury, hypertension, and glioblastoma .

HY-117639

AUT1	Potassium Channel	Neurological Disease
AUT1 is a recombinant human Kv3 channel modulator. AUT1 modulates Kv3.1b and Kv3.2a channels in human recombinant with pEC₅₀ values of 5.33 and 5.31 μM, respectively. AUT1 can be used for the research of disorders associated with dysfunction of inhibitory feedback in corticolimbic circuits, such as schizophrenia .

HY-10015

PAP-1 10+ Cited Publications 5-(4-Phenoxybutoxy)psoralen	Potassium Channel	Inflammation/Immunology
PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally active *Kv1.3* blocker (EC₅₀=2 nM). PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC₅₀=45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels. PAP-1 does not exhibit cytotoxic or phototoxic effects .

HY-B0267A

Oxybutynin chloride	mAChR Potassium Channel	Neurological Disease Cancer
Oxybutynin chloride is an oral active and competitive mAChR antagonist with K_is of 14.3 and 5.55 nM for specific [ ³H]NMS binding in the mouse bladder and cerebral cortex, respectively. Oxybutynin chloride inhibits vascular Kv channels in a manner independent of anticholinergic effect, with an IC₅₀ value of 11.51 μM. Oxybutynin chloride reduces muscle spasm in the bladder and urinary tract, can be used in study of overactive bladder syndrome (OAB) . Oxybutynin (chloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-101843

ML213	Potassium Channel	Neurological Disease
ML213 is a selective activator of *Kv7.2* and *Kv7.4* channels, enhances Kv7.2 and Kv7.4 channels with EC₅₀s of 230 and 510 nM, respectively.

HY-108577

XE991 dihydrochloride 3 Publications Verification	Potassium Channel	Neurological Disease
XE991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC₅₀s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively .

HY-108577A

XE991 3 Publications Verification	Potassium Channel	Neurological Disease
XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC₅₀s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively .

HY-108584

Flindokalner BMS-204352	Potassium Channel	Neurological Disease
Flindokalner (BMS-204352) is a potassium channel modulator. Flindokalner is a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is also a large conductance calcium-activated K channel (BKca) positive modulator. Flindokalner shows a negative modulatory activity at Kv7.1 channels (K_i=3.7 μM), and acts as a negative modulator of GABAA receptors. Flindokalner shows anxiolytic efficacy in vivo .

HY-14183

Vernakalant Hydrochloride 3 Publications Verification RSD1235 hydrochloride	Potassium Channel	Cardiovascular Disease
Vernakalant hydrochloride is a mixed voltage- and frequency-dependent Na ⁺ and atria-preferred K ⁺ channel blocker. IC₅₀ for block by Vernakalant of wild-type and mutant Kv1.5 channels Fractional block is 13.35±0.93 μM, 0.61±0.03 μM, and 1.63±0.09 μM for *Kv1.5 channel* ^wt, Kv1.5 channel ^I508F, Kv1.5 channel ^T479A**, respectively.

HY-108586

NS3623	Potassium Channel	Neurological Disease
NS3623 is an activator of human ether-a-go-go-related gene (hERG1/K_V11.1) potassium channels. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels .

HY-125469

ICA-105665 PF-04895162	Potassium Channel	Neurological Disease
ICA-105665 (PF-04895162) is a potent and orally active neuronal *Kv7.2/7.3* and Kv7.3/7.5 potassium channels opener. ICA-105665 inhibits liver mitochondrial function and bile salt export protein (BSEP) transport (IC₅₀ of 311 μM). ICA-105665 can penetrate the blood-brain barrier and has antiseizure effects .

HY-114608

RY785	Sodium Channel	Neurological Disease
RY785 is a potent and selective voltage-gated potassium (K_V2) channel inhibitor with an IC₅₀ of 0.05 μM for K_V2.2. RY785 has analgesic activity .

HY-108588

NS5806 1 Publications Verification	Potassium Channel	Cardiovascular Disease
NS5806, a potent potassium current activator, increases *K_V4.3/KChIP2* peak current amplitudes with an EC₅₀ of 5.3 μM. NS5806 slows K_V4.3 and K_V4.2 current dacay in channel complexes containing KChIP2 .

HY-108587

ICA 110381	Potassium Channel	Neurological Disease
ICA 110381 is an orally active *Kv7.2/Kv7.3* (KCNQ2/3) potassium channel activator with anticonvulsive properties. ICA 110381 is a KCNQ2/Q3 activator (EC₅₀=0.38 μM) as well as KCNQ1 antagonist (IC₅₀=15 μM) .

HY-122015

ASP2905	Potassium Channel	Neurological Disease
ASP2905 is an orally active potassium channel Kv12.2 inhibitor encoded by the Kcnh3/BEC1 gene. ASP2905 can cross the blood-brain barrier and has antipsychotic activities .

HY-108574

CP 339818 hydrochloride	Potassium Channel HCN Channel	Neurological Disease
CP 339818 hydrochloride is a non-peptide Kv1.3 channel (IC₅₀ = 200 nM) and Kv1.4 channel blocker. CP 339818 hydrochloride inhibits HCN channel with IC₅₀s of 18.9 μM and 43.4 μM against HCN1 and HCN4 (high Cl ^-). CP 339818 hydrochloride has significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. CP 339818 hydrochloride selectively blocked Kv1.3, thereby inhibiting the activation process of human T cells. CP 339818 hydrochloride can be used to study the physiological functions of HCN and Kv channels .

HY-178281

E0199	Potassium Channel Sodium Channel	Neurological Disease
E0199 is a novel potent dual-target *K_V7/Na_V* modulator that activates the K_V7 channel (K_V7.2/7.3 (EC₅₀ = 12.78 nM), K_V7.2 (EC₅₀ = 0.50 μM), and K_V7.5 (EC₅₀ = 27.14 nM) channels) while simultaneously blocks the Na_V1.7 (IC₅₀ = 0.52 μM), Na_V1.8 (IC₅₀ = 0.24 μM), and Na_V1.9 (IC₅₀ = 0.16 μM) channels. E0199 shows a potent analgesic effect without affecting heart and skeletal muscle ion channels critically in a chronic constriction injury (CCI) mouse model. E0199 can be used for Neuropathic pain (NP) research .

HY-P1280

Margatoxin 1 Publications Verification	Potassium Channel	Neurological Disease
Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of *Kv1.3* (K_d=11.7 pM). Margatoxin inhibits the Kv1.2 (K_d=6.4 pM) and Kv1.1 (K_d=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research .

HY-120033

RY796 2 Publications Verification	Sodium Channel	Neurological Disease
RY796 is a potent and selective voltage-gated potassium (K_V2) channel inhibitor with IC₅₀s of 0.25 μM and 0.09 μM for K_V2.1 and K_V2.2. RY796 has analgesic activity .

HY-161104

Kv2.1-IN-1 1 Publications Verification	Potassium Channel Apoptosis	Cardiovascular Disease Neurological Disease
Kv2.1-IN-1 is an orally active and blood-brain barrier penetrant *Kv2.1* inhibitor with an IC₅₀ of 0.07 μM. Kv2.1-IN-1 exhibits a selectivity >130 fold over other K ⁺, Na ⁺, and Ca ²⁺ ion channels. Kv2.1-IN-1 decreases the apoptosis of HEK293 cells induced by H₂O₂. Kv2.1-IN-1 produces significant neuroprotection efficacy in middle cerebral artery occlusion (MCAO) rat. Kv2.1-IN-1 can be used for the study of ischemic stroke .

HY-111996

Kv3 activator-1	Potassium Channel	Neurological Disease Inflammation/Immunology
Kv3 activator-1 is a Kv3 family voltage-gated potassium channel activator. Kv3 activator-1 reverses mechanical hyperalgesia in rat models of neuropathic and inflammatory pain, with rapid onset and long-lasting, dose-related effects. Kv3 activator-1 can be used for the research of pain .

HY-110358

QAQ dichloride	Sodium Channel	Inflammation/Immunology
QAQ dichloride, a photoswitchable voltage-gated Na_v and *K_v* channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain .

HY-172374A

KV1.3-IN-2 hydrochloride	Potassium Channel	Inflammation/Immunology
KV1.3-IN-2 hydrochloride is a kv1.3 potassium channel inhibitor without affecting hERG channel activity. KV1.3-IN-2 hydrochloride can be used in research of immune-related diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus .

HY-172374

KV1.3-IN-2	Potassium Channel	Inflammation/Immunology
KV1.3-IN-2 is a kv1.3 potassium channel inhibitor without affecting hERG channel activity. KV1.3-IN-2 can be used in research of immune-related diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus .

HY-P3055A

Dendrotoxin-I TFA DTX-I TFA	Potassium Channel	Cancer
Dendrotoxin-I (DTX-I) TFA is a potent K ⁺ channel blocker with IC₅₀s of 0.13-50 nM for voltage-gated potassium channel subunits K_V1.1, K_V1.2 and K_V1.6. Dendrotoxin-I TFA, a neurotoxin, has the potential for cancer research .

HY-P2707

α-Dendrotoxin α-DTX	Sodium Channel Potassium Channel	Neurological Disease
α-Dendrotoxin (α-DTX) is a voltage-gated K ⁺ channel blocker and an acid-sensing ion channel (ASIC) inhibitor. α-Dendrotoxin blocks *K_v1.1, K_v1.2, K_v1.6* and D-type (I_D) voltage-gated K ⁺ channels, and reversibly inhibits slowly inactivating potassium currents. α-Dendrotoxin induces epilepsy-related behaviors in mice. α-Dendrotoxin can be used in studies related to tonic-clonic seizures .

HY-P3089A

Dendrotoxin K TFA	Potassium Channel	Others
Dendrotoxin K TFA is a Kv1.1 channel blocker. Dendrotoxin K TFA determines glutamate release in CA3 neurons in a time-dependent manner through the control of the presynaptic spike waveform .

HY-P1427A

Guangxitoxin 1E TFA	Potassium Channel	Neurological Disease
Guangxitoxin 1E TFA is the TFA salt form of Guangxitoxin 1E (HY-P1427). Guangxitoxin 1E TFA is a peptide toxin and a selective inhibitor for voltage-gated potassium channel *K_V2.1* and *K_V2.2* with IC₅₀ of 1-3 nM. Guangxitoxin 1E TFA enhances glucose-stimulated intracellular calcium ion oscillations and increases insulin secretion in a glucose-dependent manner .

HY-44153

*KV2 channel* inhibitor-1**	Potassium Channel	Neurological Disease
KV2 channel inhibitor-1 is a selective **K_V2 channel inhibitor with IC₅₀*s of 0.2 μM and 0.41 μM for K_V2.1* and K_V2.2, respectively. KV2 channel inhibitor-1 possesses good selectivity over K_V1.2 (IC₅₀>10 μM). KV2 channel inhibitor-1 is >10-fold selective over Na_V channels and other K_V channels and displays weak activity on Ca_V channels .

HY-P2786A

Phrixotoxin 2	Potassium Channel	Neurological Disease
Phrixotoxin 2 is a highly selective *KV_4.2* and *KV_4.3*-channels blocker .

HY-163018

Kv3.1 modulator 2	Potassium Channel	Neurological Disease
Kv3.1 modulator 2 (compound 4) is a Kv3.1 channels modulator with an EC₅₀ value of 68 nM .

HY-P5925A

Ssm spooky toxin TFA SsTx Toxin TFA	Potassium Channel	Neurological Disease Inflammation/Immunology
Ssm Spooky Toxin TFA is found in Scolopendra mutilans that potently inhibits KCNQ (voltage-gated potassium channel family 7) channels, with IC₅₀s of 2.8 μM, 5.26 μM and 0.1-0.3 M for Kv7.4, Kv1.3, and Shal channel, respectivily. Ssm Spooky Toxin TFA inhibits cytokine generation by specifically acting on the KV1.3 channel in T cells. Ssm Spooky Toxin TFA plays an essential role in the centipede’s circulatory system .

HY-120375

LUF7346	Potassium Channel	Cardiovascular Disease
LUF7346 is a potent Kv11.1 (hERG) channel negative allosteric modulator, with an IC₅₀ of 35.6 ± 3.2 nM .

HY-P5818

BDS-II	Sodium Channel	Neurological Disease
BDS-II is a peptide toxin, and is composed of 43 amino acids. BDS-II is a selective Kv3.4 channel inhibitor .

HY-137986

LUF7244	Potassium Channel	Inflammation/Immunology
LUF7244 is a selective allosteric modulator of **K_v11.1 channels**. LUF7244 inhibits early afterdepolarizations. LUF7244 can be used for anti-arrhythmia research .

HY-10015R

PAP-1 (Standard) 5-(4-Phenoxybutoxy)psoralen (Standard)	Reference Standards Potassium Channel	Inflammation/Immunology
PAP-1 (Standard) is the analytical standard of PAP-1. This product is intended for research and analytical applications. PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC50=2 nM). PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC50=45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels. PAP-1 does not exhibit cytotoxic or phototoxic effects .

HY-118387

AVE-0118	Potassium Channel	Cardiovascular Disease
AVE-0118 is a *Kv1.5* potassium channel blocker and antiarrhythmic agent. AVE-0118 blocks neuronal *Kv1.5* potassium channels, thereby enhancing the release of norepinephrine. AVE-0118 enhances field stimulation-induced neurogenic contraction, an effect sensitive to α1-adrenergic receptor blockade. AVE-0118 terminates persistent atrial fibrillation in some dogs. AVE-0118 is applicable to research related to atrial fibrillation and persistent atrial fibrillation .

HY-P1427

Guangxitoxin 1E	Potassium Channel	Neurological Disease
Guangxitoxin 1E is a potent and selective blocker of *K_V2.1* and **K_V2.2 channels. Guangxitoxin 1E inhibits K_V2 with an IC₅₀ of 1-3 nM. K_V2 channels** underlie delayed-rectifier potassium currents in various neurons .

HY-P3055

Dendrotoxin-I DTX-I	Potassium Channel	Neurological Disease Cancer
Dendrotoxin-I (DTX-I) is a potent K ⁺ channels blocker with IC₅₀s of 0.13-50 nM for voltage-gated potassium channel subunits K_V1.1, K_V1.2 and K_V1.6, respectively. Dendrotoxin-I, a neurotoxin, has the potential for cancer research .

HY-P5925

Ssm spooky toxin SsTx Toxin	Potassium Channel	Neurological Disease Inflammation/Immunology
Ssm Spooky Toxin is found in Scolopendra mutilans that potently inhibits KCNQ (voltage-gated potassium channel family 7) channels, with IC₅₀s of 2.8 μM, 5.26 μM and 0.1-0.3 M for Kv7.4, Kv1.3, and Shal channel, respectivily. Ssm Spooky Toxin inhibits cytokine generation by specifically acting on the KV1.3 channel in T cells. Ssm Spooky Toxin plays an essential role in the centipede’s circulatory system .

HY-P5155

Stromatoxin 1	Potassium Channel	Neurological Disease
Stromatoxin 1 is an inhibitor of Potassium Channel, a peptide which can be isolated from tarantulas. Stromatoxin 1 selectively inhibits *K(V)2.1, K(V)2.2, K(V)4.2, and K(V)2.1/9.3 channels. K(V)2.1 and K(V)2.2, but not K(V)4.2, channel* subunits play a key role in opposing both myogenic and neurogenic urinary bladder smooth muscle (UBSM) contractions in rats .

HY-159506

Bimokalner Bimokalnerum	Potassium Channel	Neurological Disease
Bimokalner (Bimokalnerum) is a voltage-gated potassium channel (Kv7.4) agonist .

HY-180468

Kv7 activator-2	Potassium Channel	Neurological Disease
Kv7 activator-2 (A14a) is a Kv7 potassium channel activator. Kv7 activator-2 can be used for the research of neurological disease, such as epilepsy .

HY-155516

KV1.3-IN-1	Potassium Channel	Inflammation/Immunology
KV1.3-IN-1 (Compound trans-18) is a *KV1.3* channel inhibitor (IC₅₀: 230 nM and 26.12 nM in Ltk cells and PHA-activated T-lymphocytes respectively). KV1.3-IN-1 impairs intracellular Ca ²⁺ signaling. KV1.3-IN-1 inhibits T-cell activation, proliferation, and colony formation .

HY-P1281

Kaliotoxin	Potassium Channel	Neurological Disease
Kaliotoxin is a peptidyl inhibitor of neuronal BK-Type. Kaliotoxin can specific inhibit Kv channels and calcium-activated potassium channels. Kaliotoxin can be used for the research of the regulation of membrane potential and neuron excitability .

HY-B0267R

Oxybutynin (Standard)	Reference Standards mAChR Potassium Channel	Neurological Disease
Oxybutynin (Standard) is the analytical standard of Oxybutynin. This product is intended for research and analytical applications. Oxybutynin is an anticholinergic agent, which inhibits vascular K_v channels in a concentration-dependent manner, with an IC₅₀ of 11.51 μM . Oxybutynin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-110358A

QAQ	Sodium Channel	Inflammation/Immunology
QAQ dichloride dichloride, a photoswitchable voltage-gated Na_v and *K_v* channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain .

HY-114540

CP-339818	Potassium Channel HCN Channel	Neurological Disease
CP-339818 is a non-peptide Kv1.3 channel (IC₅₀ = 200 nM) and Kv1.4 channel blocker. CP 339818 inhibits HCN channel with IC₅₀s of 18.9 μM and 43.4 μM against HCN1 and HCN4 (high Cl ^-). CP-339818 has significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. CP-339818 selectively blocked Kv1.3, thereby inhibiting the activation process of human T cells. CP-339818 can be used to study the physiological functions of HCN and Kv channels .

Cat. No.	Product Name	Target	Research Area

HY-P3507

Dalazatide ShK-186	Potassium Channel	Metabolic Disease Inflammation/Immunology
Dalazatide (ShK-186) is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease .

HY-P3507A

Dalazatide TFA ShK-186 TFA	Potassium Channel	Metabolic Disease Inflammation/Immunology
Dalazatide (ShK-186) TFA is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide TFA can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease .

HY-P1280

Margatoxin 1 Publications Verification	Potassium Channel	Neurological Disease
Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of *Kv1.3* (K_d=11.7 pM). Margatoxin inhibits the Kv1.2 (K_d=6.4 pM) and Kv1.1 (K_d=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research .

HY-P3055A

Dendrotoxin-I TFA DTX-I TFA	Potassium Channel	Cancer
Dendrotoxin-I (DTX-I) TFA is a potent K ⁺ channel blocker with IC₅₀s of 0.13-50 nM for voltage-gated potassium channel subunits K_V1.1, K_V1.2 and K_V1.6. Dendrotoxin-I TFA, a neurotoxin, has the potential for cancer research .

HY-P2707

α-Dendrotoxin α-DTX	Sodium Channel Potassium Channel	Neurological Disease
α-Dendrotoxin (α-DTX) is a voltage-gated K ⁺ channel blocker and an acid-sensing ion channel (ASIC) inhibitor. α-Dendrotoxin blocks *K_v1.1, K_v1.2, K_v1.6* and D-type (I_D) voltage-gated K ⁺ channels, and reversibly inhibits slowly inactivating potassium currents. α-Dendrotoxin induces epilepsy-related behaviors in mice. α-Dendrotoxin can be used in studies related to tonic-clonic seizures .

HY-P3089A

Dendrotoxin K TFA	Potassium Channel	Others
Dendrotoxin K TFA is a Kv1.1 channel blocker. Dendrotoxin K TFA determines glutamate release in CA3 neurons in a time-dependent manner through the control of the presynaptic spike waveform .

HY-P1427A

Guangxitoxin 1E TFA	Potassium Channel	Neurological Disease
Guangxitoxin 1E TFA is the TFA salt form of Guangxitoxin 1E (HY-P1427). Guangxitoxin 1E TFA is a peptide toxin and a selective inhibitor for voltage-gated potassium channel *K_V2.1* and *K_V2.2* with IC₅₀ of 1-3 nM. Guangxitoxin 1E TFA enhances glucose-stimulated intracellular calcium ion oscillations and increases insulin secretion in a glucose-dependent manner .

HY-P5156

BDS-I	Potassium Channel	Neurological Disease
BDS-I known as blood depressing substance, is a marine toxin which can be extracted from Anemonia sulcata. BDS-I is a specific inhibitor of Potassium Channel, targeting to *Kv3.4*. BDS-I inhibits Aβ1-42-induced enhancement of KV3.4 activity, caspase-3 activation, and abnormal nuclear morphology of NGF-differentiated PC-12 cells. BDS-I reverts the Aβ peptide-induced cell death .

HY-P3071

ShK toxin Stichodactyla helianthus neurotoxin	Potassium Channel	Neurological Disease Inflammation/Immunology
ShK toxin blocks voltage-dependent potassium channel (K_v1.3 *channel). ShK toxin can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus*). ShK toxin competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin suppresses K+ currents in cultured rat dorsal root ganglion neurons. ShK toxin also inhibits T lymphocyte proliferation .

HY-P2786A

Phrixotoxin 2	Potassium Channel	Neurological Disease
Phrixotoxin 2 is a highly selective *KV_4.2* and *KV_4.3*-channels blocker .

HY-P5925A

Ssm spooky toxin TFA SsTx Toxin TFA	Potassium Channel	Neurological Disease Inflammation/Immunology
Ssm Spooky Toxin TFA is found in Scolopendra mutilans that potently inhibits KCNQ (voltage-gated potassium channel family 7) channels, with IC₅₀s of 2.8 μM, 5.26 μM and 0.1-0.3 M for Kv7.4, Kv1.3, and Shal channel, respectivily. Ssm Spooky Toxin TFA inhibits cytokine generation by specifically acting on the KV1.3 channel in T cells. Ssm Spooky Toxin TFA plays an essential role in the centipede’s circulatory system .

HY-P5818

BDS-II	Sodium Channel	Neurological Disease
BDS-II is a peptide toxin, and is composed of 43 amino acids. BDS-II is a selective Kv3.4 channel inhibitor .

HY-P1409A

ADWX 1 TFA 1 Publications Verification	Potassium Channel	Inflammation/Immunology
ADWX 1 TFA is a new peptide inhibitor that is potent and selective for *Kv1.3* with an IC₅₀ value of 1.89 pM. ADWX 1 inhibits *Kv1.3* channel activity specifically to inhibit both the initial calcium signaling and NF-κB activation. ADWX 1 TFA ameliorates the disease in rats of experimental autoimmune encephalomyelitis (EAE) models. ADWX 1 TFA can be used to study T cell-mediated autoimmune diseases .

HY-P5182A

HsTX1 TFA	Potassium Channel	Inflammation/Immunology
HsTX1 (TFA) toxin, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. HsTX1 (TFA) is an the inhibitor of potassium channel, with IC₅₀ for Kv1.3 of 12 pM and inhibits T_EM cell activation and attenuates inflammation in autoimmunity .

HY-P5917A

Vm24-toxin TFA Vaejovis mexicanus peptide 24 TFA	Potassium Channel	Inflammation/Immunology Cancer
Vm24-toxin (Vaejovis mexicanus peptide 24) TFA, a 36-residue peptide, is a potent and selective *Kv1.3* blocker with a K_d of ~3 pM in lymphocytes. Vm24-toxin TFA shows >1500-fold affinity for Kv1.3 over other assayed potassium channels. Vm24-toxin TFA folds into a distorted cystine-stabilized α/β motif consisting of a single-turn α-helix and a three-stranded antiparallel β-sheet, stabilized by four disulfide bridges. Vm24-toxin TFA attenuates the CD4 ⁺ effector memory T cell response to T cell receptor (TCR) stimulation .

HY-P1427

Guangxitoxin 1E	Potassium Channel	Neurological Disease
Guangxitoxin 1E is a potent and selective blocker of *K_V2.1* and **K_V2.2 channels. Guangxitoxin 1E inhibits K_V2 with an IC₅₀ of 1-3 nM. K_V2 channels** underlie delayed-rectifier potassium currents in various neurons .

HY-P3055

Dendrotoxin-I DTX-I	Potassium Channel	Neurological Disease Cancer
Dendrotoxin-I (DTX-I) is a potent K ⁺ channels blocker with IC₅₀s of 0.13-50 nM for voltage-gated potassium channel subunits K_V1.1, K_V1.2 and K_V1.6, respectively. Dendrotoxin-I, a neurotoxin, has the potential for cancer research .

HY-P5925

Ssm spooky toxin SsTx Toxin	Potassium Channel	Neurological Disease Inflammation/Immunology
Ssm Spooky Toxin is found in Scolopendra mutilans that potently inhibits KCNQ (voltage-gated potassium channel family 7) channels, with IC₅₀s of 2.8 μM, 5.26 μM and 0.1-0.3 M for Kv7.4, Kv1.3, and Shal channel, respectivily. Ssm Spooky Toxin inhibits cytokine generation by specifically acting on the KV1.3 channel in T cells. Ssm Spooky Toxin plays an essential role in the centipede’s circulatory system .

HY-P5155

Stromatoxin 1	Potassium Channel	Neurological Disease
Stromatoxin 1 is an inhibitor of Potassium Channel, a peptide which can be isolated from tarantulas. Stromatoxin 1 selectively inhibits *K(V)2.1, K(V)2.2, K(V)4.2, and K(V)2.1/9.3 channels. K(V)2.1 and K(V)2.2, but not K(V)4.2, channel* subunits play a key role in opposing both myogenic and neurogenic urinary bladder smooth muscle (UBSM) contractions in rats .

HY-P5916

VSTx-3 κ-Theraphotoxin-Gr4a; Kappa-TRTX-Gr4a; Voltage sensor toxin 3; Peptide F	Peptides Potassium Channel	Neurological Disease
VSTx-3 is a *K_V* channel blocker. VSTx-3 is demonstrated to be a potent, TTX-sensitive sodium channel blocker and especially, a potent blocker of NaV1.8 channels (IC₅₀ 0.19 μM for hNaV1.3, 0.43 μM for hNaV1.7 and 0.77 μM for hNaV1.8 channels).

HY-P3071A

ShK toxin TFA Stichodactyla helianthus neurotoxin TFA	Potassium Channel	Neurological Disease Inflammation/Immunology
ShK toxin TFA (Stichodactyla helianthus neurotoxin TFA) is a neurotoxin. ShK toxin TFA blocks voltage-dependent potassium channel (K_v1.3 *channel). ShK toxin TFA can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus*). ShK toxin TFA competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin TFA suppresses K ⁺ currents in cultured rat dorsal root ganglion neurons. ShK toxin TFA also inhibits T lymphocyte proliferation .

HY-P1441A

Mambalgin 1 TFA	Sodium Channel	Neurological Disease
Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC₅₀ values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.

HY-P1426

AmmTX3	Potassium Channel	Neurological Disease
AmmTX3 is a peptide toxin identified from the venom of the scorpion Androctonus mauretanicus. AmmTX3 is a highly specific blocker of *K_v4* channels, which selectively and almost completely blocks transient A-type K ⁺ currents with a K_i of 131 nM. AmmTX3 induces epileptiform behaviors and causes death in mice receiving intracerebroventricular injection. AmmTX3 increases the excitability of dentate gyrus granule cells, reduces GABAergic inhibition, enhances and stabilizes the EPSP-spike component of long-term potentiation, and impairs reference memory. AmmTX3 can be used in research related to pain, epilepsy, and autism spectrum disorder .

HY-P1281

Kaliotoxin	Potassium Channel	Neurological Disease
Kaliotoxin is a peptidyl inhibitor of neuronal BK-Type. Kaliotoxin can specific inhibit Kv channels and calcium-activated potassium channels. Kaliotoxin can be used for the research of the regulation of membrane potential and neuron excitability .

HY-P5788

Hemitoxin	Potassium Channel	Neurological Disease
Hemitoxin, a scorpion-venom peptide, is a K ⁺ channel blocker. Hemitoxin blocks rat Kv1.1, Kv1.2 and Kv1.3 channels expressed in Xenopus oocytes with IC₅₀ values of 13 nM, 16 nM and 2 nM, respectively .

HY-P1886

*Kv3, Channel* Containing Protein (567-585)**	Potassium Channel	Neurological Disease
Kv3, Channel Containing Protein (567-585) corresponds to amino acids 567 to 585 fragment of the Kv3.1b channel containing protein. Kv3 channel protein is expressed by parvalbumin (PV)-containing pallidal neurons .

HY-P5771

Jingzhaotoxin-IX	Sodium Channel	Neurological Disease
Jingzhaotoxin-IX, a C-terminally amidated peptide composed of 35 amino acid residues, is a neurotoxin. Jingzhaotoxin-IX inhibits voltage-gated sodium channels (both tetrodotoxin-resistant and tetrodotoxin-sensitive isoforms) and Kv2.1 channel. Jingzhaotoxin-IX has no effect on delayed rectifier potassium channel Kv1.1, 1.2 and 1.3 .

HY-P5870

KTX-Sp2	Potassium Channel	Inflammation/Immunology
KTX-Sp2 is a potassium channel toxin. KTX-Sp2 effectively blocks three types of exogenous voltage-gated potassium channels: Kv1.1, Kv1.2 and Kv1.3. Ktx-Sp2 inhibits endogenous Kv1.3 and suppresses Ca ²⁺ signaling in Jurkat T cells. Ktx-Sp2 inhibits IL-2 secretion from activated Jurkat T cells .

HY-P5873

Jingzhaotoxin-X JZTX-X	Potassium Channel	Neurological Disease
Jingzhaotoxin-X (JZTX-X) is a selective *Kv4.2* and *Kv4.3* potassium channels inhibitor. Jingzhaotoxin-X causes long-lasting mechanical hyperalgesia .

HY-P3316

OSK-1	Potassium Channel	Neurological Disease Inflammation/Immunology
OSK-1 is a potent **K_v channel blocker with IC₅₀*s of of 0.6 nM, 5.4 nM, 0.014 nM for K_v1.1,* K_v1.2 and K_v1.3, respectively. OSK1 is a moderate blocker of Ca ²⁺-activated K_Ca3.1 channel with an IC₅₀ of 225 nM. OSK-1 belongs to α-KTx3 toxins and is used as a immunosuppressive agent .

HY-P1440A

BeKm-1 TFA	Potassium Channel	Neurological Disease
BeKm-1 TFA is a potent and selective KV11.1 (hERG) channel blocker. BeKm-1 TFA is selective for KV11.1 over a panel of 14 other potassium channels. BeKm-1 TFA dose-dependently prolongs QTc interval in isolated rabbit heart.

HY-P3014

Hongotoxin-1	Potassium Channel	Others
Hongotoxin-1, isolated from venom of Centruroides limbatus, is the inhibitor of potassium channel, with IC₅₀ for? Kv1.1, Kv1.2, Kv1.3, and Kv1.6 of 31 pM, 170 pM, 86 pM,and 6000 pM, respectively .

HY-P5871

Jingzhaotoxin-XII JzTx-XII	Potassium Channel	Others
Jingzhaotoxin-XII (JzTx-XII) is a specific *Kv4.1* channel inhibitor with an IC₅₀ of 0.363 μM. Jingzhaotoxin-XII interacts with the channels by modifying the gating behavior .

HY-P5871A

Jingzhaotoxin-XII TFA JzTx-XII TFA	Potassium Channel	Others
Jingzhaotoxin-XII (JzTx-XII) TFA is a specific *Kv4.1* channel inhibitor with an IC₅₀ of 0.363 μM. Jingzhaotoxin-XII TFA interacts with the channels by modifying the gating behavior .

HY-P5853

Aam-KTX	Potassium Channel	Inflammation/Immunology
Aam-KTX is a **K_v channel inhibitor with IC₅₀ values of 1.1 nM and >750 nM for K_v**1.3 and *K_v*1.1, respectively. Aam-KTX is a toxic peptide obtained from the venom of the scorpion Mesobuthus eupeus. Aam-KTX has potential in autoimmune diseases research .

HY-P2710

Noxiustoxin	Potassium Channel	Neurological Disease Inflammation/Immunology
Noxiustoxin is a toxin from the venom of the Mexican scorpion Centruroides noxius which block voltage-dependent potassium channel (Kv1.3, IC₅₀ = 360 nM), and calcium-activated potassium channel. Noxiustoxin plays an important role in neuroinflammatory disease .

HY-P2785A

Phrixotoxin-1 TFA	Potassium Channel	Neurological Disease
Phrixotoxin-1 (TFA), from the venom of the theraphosid spider Phrixotrichus auratus, is a specific peptide inhibitor of Kv4 potassium *channel* .

HY-P1274

ShK-Dap22	Potassium Channel	Inflammation/Immunology
ShK-Dap22 is a potent *Kv1.3*-specific immunosuppressive Polypeptide. ShK-Dap22 is a selective Kv1.3 channel blocker with IC₅₀s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively .

HY-P1280A

Margatoxin TFA	Potassium Channel	Neurological Disease
Margatoxin TFA, an alpha-KTx scorpion toxin, is a high affinity inhibitor of *Kv1.3* (K_d=11.7 pM). Margatoxin TFA inhibits the Kv1.2 (K_d=6.4 pM) and Kv1.1 (K_d=4.2 nM). Margatoxin TFA, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research .

HY-P3089

Dendrotoxin K	Potassium Channel	Others
Dendrotoxin K is a Kv1.1 channel blocker. Dendrotoxin K determines glutamate release in CA3 neurons in a time-dependent manner through the control of the presynaptic spike waveform .

HY-P2785

Phrixotoxin-1	Potassium Channel	Neurological Disease
Phrixotoxin 1, from the venom of the theraphosid spider Phrixotrichus auratus, is a specific peptide inhibitor of Kv4 potassium channel .

HY-P1409

ADWX 1	Potassium Channel	Inflammation/Immunology
ADWX 1 is a new peptide inhibitor that is potent and selective for *Kv1.3* with an IC₅₀ value of 1.89 pM. ADWX 1 inhibits *Kv1.3* channel activity specifically to inhibit both the initial calcium signaling and NF-κB activation. ADWX 1 ameliorates the disease in rats of experimental autoimmune encephalomyelitis (EAE) models. ADWX 1 can be used to study T cell-mediated autoimmune diseases .

HY-P10572

HG1 Toxin	Ser/Thr Protease Potassium Channel	Inflammation/Immunology Endocrinology
HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, which has the activity of inhibiting potassium channel Kv1.3. HG1 Toxin also has the activity of inhibiting trypsin (K_i=107 nM) and can be used in the study of autoimmune diseases .

HY-P4742A

6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA 6-FAM-AEEAC-SHK TFA	Biochemical Assay Reagents Potassium Channel	Neurological Disease
6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA (6-FAM-AEEAC-SHK TFA) is a peptide neurotoxin conjugated with a fluorescent marker. 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA can block voltage-gated potassium channels (kv1.1 and kv1.2) to prolong the duration of action potentials, thereby affecting the conduction of neural signals. 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA can be used in neuroscience research .

HY-P5931

Spinoxin Potassium channel toxin alpha-KTx 6.13; SPX; α-KTx6.13	Potassium Channel	Inflammation/Immunology Cancer
Spinoxin isolated from the venom of scorpion Heterometrus spinifer, is a 34-residue peptide neurotoxin cross-linked by four disulfide bridges. Spinoxin is a potent inhibitor of Kv1.3 potassium channel (IC₅₀ = 63 nM), considering to be valid molecular targets in the diagnostics and therapy of various autoimmune disorders and cancers .

HY-P5182

HsTX1	Potassium Channel	Inflammation/Immunology
HsTX1, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. HsTX1, an the inhibitor of potassium channel, with IC₅₀ for Kv1.3 of 12 pM inhibits T_EM cell activation and attenuates inflammation in autoimmunity .

HY-P1424

Lei-Dab7	Potassium Channel	Neurological Disease
Lei-Dab7 is a potent and selective SK2 (KCa2.2) channels blocker with a K_d of 3.8 nM. Lei-Dab7 shows low or no activity on KCa1, KCa3, Kv and Kir2.1 channels .

HY-P5917

Vm24-toxin Vaejovis mexicanus peptide 24	Potassium Channel	Inflammation/Immunology Cancer
Vm24-toxin (Vaejovis mexicanus peptide 24), a 36-residue peptide, is a potent and selective *Kv1.3* blocker with a K_d of ~3 pM in lymphocytes. Vm24-toxin shows >1500-fold affinity for Kv1.3 over other assayed potassium channels. Vm24-toxin folds into a distorted cystine-stabilized α/β motif consisting of a single-turn α-helix and a three-stranded antiparallel β-sheet, stabilized by four disulfide bridges. Vm24-toxin attenuates the CD4 ⁺ effector memory T cell response to T cell receptor (TCR) stimulation .

HY-P1424A

Lei-Dab7 TFA	Potassium Channel	Neurological Disease
Lei-Dab7 TFA is a high affinity, selective K_Ca2.2 (SK2) channel blocker (K_d=3.8 nM). Lei-Dab7 TFA exhibits >200-fold selectivity for K_Ca2.2 over K_Ca2.1, K_Ca2.3, K_Ca3.1, K_v and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.

HY-P1426A

AmmTX3 TFA	Potassium Channel	Neurological Disease
AmmTX3 TFA is a peptide toxin identified from the venom of the scorpion Androctonus mauretanicus. AmmTX3 TFA is a highly specific blocker of *K_v4* channels, which selectively and almost completely blocks transient A-type K ⁺ currents with a K_i of 131 nM. AmmTX3 TFA induces epileptiform behaviors and causes death in mice receiving intracerebroventricular injection. AmmTX3 TFA increases the excitability of dentate gyrus granule cells, reduces GABAergic inhibition, enhances and stabilizes the EPSP-spike component of long-term potentiation, and impairs reference memory. AmmTX3 TFA can be used in research related to pain, epilepsy, and autism spectrum disorder .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1584

Halofuginone Maximum Cited Publications 20 Publications Verification RU-19110	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Classification of Application Fields Dichroa febrifuga Lour Saxifragaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N1584A

Halofuginone hydrobromide Maximum Cited Publications 20 Publications Verification RU-19110 hydrobromide	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Classification of Application Fields Dichroa febrifuga Lour Saxifragaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-P1280

Margatoxin 1 Publications Verification	Natural Products Animals Neurological Disease Disease Research Fields Source Classification	Potassium Channel
Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of *Kv1.3* (K_d=11.7 pM). Margatoxin inhibits the Kv1.2 (K_d=6.4 pM) and Kv1.1 (K_d=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research .

HY-N1584R

Halofuginone (Standard) RU-19110 (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Dichroa febrifuga Lour Saxifragaceae Plants Source Classification	Reference Standards DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (Standard) is the analytical standard of Halofuginone. This product is intended for research and analytical applications. Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N1584AR

Halofuginone hydrobromide (Standard) RU-19110 hydrobromide (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Dichroa febrifuga Lour Saxifragaceae Plants Source Classification	Reference Standards DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (hydrobromide) (Standard) is the analytical standard of Halofuginone (hydrobromide). This product is intended for research and analytical applications. Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-P3055

Dendrotoxin-I DTX-I	Animals Cyclopeptides Animal Venoms Source Classification	Potassium Channel
Dendrotoxin-I (DTX-I) is a potent K ⁺ channels blocker with IC₅₀s of 0.13-50 nM for voltage-gated potassium channel subunits K_V1.1, K_V1.2 and K_V1.6, respectively. Dendrotoxin-I, a neurotoxin, has the potential for cancer research .

HY-N8372

Nalanthalide	Microorganisms Terpenoids Diterpenoids Source Classification	Potassium Channel
Nalanthalide is a voltage-gated potassium channel *Kv1.3* blocker (IC₅₀=3.9 µM) and a potential immunosuppressant. Nalanthalide can be used for research on inflammatory immune diseases, such as neuroinflammation .

HY-W105272R

2′-Deoxyadenosine 5′-monophosphate disodium (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Halofuginone (Standard) is the analytical standard of Halofuginone. This product is intended for research and analytical applications. Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-W002097R

1-(5-Methylthiophen-2-yl)ethan-1-one (Standard) 2-Acetyl-5-methylthiophene (Standard)	Structural Classification Natural Products Rubiaceae Plants Coffea arabica L. Source Classification	Reference Standards Others
Amifampridine (Standard) is the analytical standard of Amifampridine. This product is intended for research and analytical applications. Amifampridine (3,4-Diaminopyridine) is an orally active, potent and cell permeable voltage-gated potassium (Kv) channel blocker (PCB). Amifampridine is efficacy in the reversal of BoNT/A (HY-P79153) intoxication. Amifampridine increases transmitter release from neuromuscular junctions (NMJs). Amifampridine can be used for Lambert-Eaton myasthenic syndrome (LEMS) research .

HY-N15339A

Convolamine hydrochloride	Structural Classification Alkaloids Microorganisms Tropane Alkaloids Source Classification	Sigma Receptor
Convolamine hydrochloride is a tropane alkaloid and a potent Sigma-1 receptor positive allosteric modulator with an IC₅₀ value of 289 nM. Convolamine hydrochloride can be extracted from Convolvulus plauricalis. Convolamine hydrochloride exhibits cognitive-improving and neuroprotective properties. Convolamine hydrochloride can be used in research related to Wolfram syndrome and Alzheimer's disease .

Cat. No.	Product Name	Chemical Structure

HY-B0267AS

Oxybutynin-d11 chloride
Oxybutynin-d₁₁ (chloride) is the deuterium labeled Oxybutynin chloride. Oxybutynin chloride is an anticholinergic agent, which inhibits vascular Kv channels in a concentration-dependent manner, with an IC₅₀ of 11.51 μM .

HY-14946S

Amifampridine-d3

Amifampridine-d₃ (3,4-Diaminopyridine-d₃) is deuterium labeled Amifampridine. Amifampridine (3,4-Diaminopyridine) is an orally active, potent and cell permeable voltage-gated potassium (K_v) channel blocker (PCB). Amifampridine is efficacy in the reversal of BoNT/A (HY-P79153) intoxication. Amifampridine increases transmitter release from neuromuscular junctions (NMJs). Amifampridine can be used for Lambert-Eaton myasthenic syndrome (LEMS) research .

HY-143690S

Oxybutynin-d10 hydrochloride

Oxybutynin-d₁₀ hydrochloride is the deuterium labeled Oxybutynin (HY-B0267). Oxybutynin is an anticholinergic agent, which inhibits vascular K_v channels in a concentration-dependent manner, with an IC₅₀ of 11.51 μM . Oxybutynin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W709349S

Flupirtine-d6 hydrochloride

Flupirtine-d₆ (D 9998-d₆) hydrochloride is the deuterium labeled Flupirtine hydrochloride (HY-W709349). Flupirtine hydrochloride is an orally active, blood-brain barrier-crossing non-opioid analgesic and neuroprotective agent. Flupirtine hydrochloride is a neuronal potassium channel opener (Kv7 activator), a NMDA receptor antagonist and a GABA receptor activator. Flupirtine hydrochloride stabilizes blood-brain-barrier integrity, reduces oxidative stress and brain leukocyte infiltration, enhances angioneurogenesis, suppresses calcium influx, stabilizes neuronal resting membrane potential, and counteracts focal cerebral ischemia. Flupirtine hydrochloride exhibits analgesic, muscle relaxant properties, protects neurons from excitotoxic, ischemic, or cytokine-mediated death. Flupirtine hydrochloride functions as a non-opioid analgesic without antipyretic or antiphlogistic properties, shows no relevant affinity to opiate receptor. Flupirtine hydrochloride can be used for the research of focal cerebral ischemia, pain, Alzheimer’s disease, or multiple sclerosis .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Kv channels

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products