Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
LTK
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "LTK" in MCE Product Catalog:
Cat. No.: HY-160461
CAS No.: 71118-00-8
Target:
Research Areas:
LTK-14A, a derivative of Garcinol (HY-107569), is a selective histone butyrylation inhibitor. LTK-14A does not affect acetylation. LTK-14A significantly inhibits the butyrylation of H4K5 and downregulated the expression of proadipogenic genes, thus culminating in abolished adipogenesis. LTK-14A can be used for the study of obesity .
Cat. No.: HY-108263B
CAS No.: 155848-20-7
Synonyms: (R)-CGP52421
Target:
Research Areas:
(R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML) .
Target:
Research Areas:
KV1.3-IN-1 (Compound trans-18) is a KV1.3 channel inhibitor (IC50: 230 nM and 26.12 nM in Ltk cells and PHA-activated T-lymphocytes respectively). KV1.3-IN-1 impairs intracellular Ca 2+ signaling. KV1.3-IN-1 inhibits T-cell activation, proliferation, and colony formation .
Cat. No.: HY-145257
CAS No.: 1808389-92-5
Target:
Research Areas:
GABAA receptor agent 5 (compound 018) is a potent γ-GABAAR antagonist with an Ki of 0.020 µM. GABAA receptor agent 5 shows γ-GABAAR antagonist activity with low cellular membrane permeability .
Cat. No.: HY-110347
CAS No.: 1883548-93-3
Mps1-IN-1 dihydrochloride is a potent and ATP-competitive Mps1 kinase inhibitor with an IC50 of 367 nM. Mps1-IN-1 dihydrochloride inhibit Mps1 mitotic kinase activity and abrogates spindle assembly checkpoint (SAC) function. Mps1-IN-1 dihydrochloride decreases the viability of both cancer and ‘normal’ cells .
Cat. No.: HY-RS07884
Target:
Research Areas:
LTK Human Pre-designed siRNA Set A contains three designed siRNAs for LTK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19111
Target:
Research Areas:
Ltk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ltk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25601
Target:
Research Areas:
Ltk Rat Pre-designed siRNA Set A contains three designed siRNAs for Ltk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-171155
CAS No.: 1360282-15-0
Target:
Research Areas:
CLIP1-LTK fusion protein regulator-1 is a 7-azaindol-6-amine class CLIP1-LTK fusion protein regulator and CLIP1-LTK fusion protein receptor inhibitor. CLIP1-LTK fusion protein regulator-1 suppresses abnormal proliferation of CLIP1-LTK-dependent cells.CLIP1-LTK fusion protein regulator-1 can be used for the research of non-small cell lung cancer .
Cat. No.: HY-145256
CAS No.: 2035203-91-7
Target:
Research Areas:
GABAA receptor agent 4 (compound 1e) is a potent γ-GABAAR antagonist with an Ki of 0.18 µM. GABAA receptor agent 4 efficiently rescues inhibition of T cell proliferation. GABAA receptor agent 4 has the immunomodulatory potential .
Cat. No.: HY-131909
CAS No.: 2226742-61-4
Target:
Research Areas:
CJ-2360 is a potent and orally active ALK inhibitor with IC50s of 2.2, 4.0, 8.8, 6.3, and 8.9 nM against wild-type ALK and F1197M, G1269A, L1196M, and S1206Y ALK mutants, respectively. CJ-2360 displays potent inhibitory activity against two clinically reported ALK mutants (C1156Y and L1196M) and a few other kinases (LTK, MERTK, CLK1, DAPK1, and DAPK2) among the 468 kinases evaluated .
Cat. No.: HY-15018A
CAS No.: 785048-28-4
Target:
Research Areas:
SSR126768A free base is an orally active antagonist for oxytocin receptor, with Ki of 0.44 nM. SSR126768A free base is a tocolytic agent, that antagonizes the Oxytocin (HY-17571)-induced intracellular Ca 2+ increase and prostaglandin release in human uterine smooth muscle cells, inhibits thus the Oxytocin (HY-17571)-induced uterine contraction and delays parturition in pregnant rats in labor .
Cat. No.: HY-P703767
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Leukocyte tyrosine kinase receptor; LTK
Cat. No.: HY-P701795
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LTK; Leukocyte tyrosine kinase receptor; Protein tyrosine kinase 1
Species:
Source:
Cat. No.: HY-12962A
CAS No.: 1784252-90-9
Target:
Research Areas:
NMDA-IN-1 dihydrochloride is a selective NMDA NR2B antagonist with a Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM. NMDA-IN-1 dihydrochloride inhibits Glu/Gly stimulated Ca2+ flux in Ltk- cells expressing the hNR1a/NR2B with a IC50 of 9.7 nM. NMDA-IN-1 dihydrochloride has no activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor. NMDA-IN-1 dihydrochloride shows excellent activity in the mechanical hyperalgesia assay in rats. NMDA-IN-1 dihydrochloride can be used for the studies of stroke, parkinson, and neuropathic pain .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
