Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
35 Results for "
MBD
" in MedChemExpress (MCE) Product Catalog:
Products (35)
35 Results for "MBD" in MCE Product Catalog:
Synonyms: 7-(p-Methoxybenzylamino)-4-nitrobenz-2,1,3-oxadiazole
Target:
Research Areas:
MBD (7-(p-Methoxybenzylamino)-4-nitrobenz-2,1,3-oxadiazole) is a hydrophobic fluorescent probe that is used to detect conformational changes of the complement subcomponent C1r during its autoactivation process. MBD acts by selectively binding to exposed hydrophobic regions on the C1r macromolecule. The detection wavelength of MBD in the free unbound state is Ex/Em = 490/560 nm, whereas the maximum emission wavelength of MBD upon binding to C1r exhibits a blue shift of approximately 20 nm relative to 560 nm .
2
2 Cited Publications
Target:
Research Areas:
KCC-07 is a potent and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling . KCC-07 is a TRACER (transcriptional regulation via active control of epigenetic reprogramming) that can stimulate ER transcriptional activity . KCC-07 can be used for the stduy of breast cancer .
Cat. No.: HY-168615
CAS No.: 2991818-13-2
Research Areas:
MGD-28 is an orally effective cereblon-dependent molecular glue degrader that potently degrades CK1α, IKZF1, IKZF2, and IKZF3, with respective DC50 values of 7.8, 3.8, 56.3, and 7.1 nM. MGD-28 also induces the degradation of multiple novel substrate proteins including ZFP91, DTWD1, ZNFX1, MBD1, and MBD3 via a CRBN/Cullin- and proteasome-dependent mechanism. MGD-28 induces cell apoptosis. MGD-28 is used in the research of multiple myeloma, acute myeloid leukemia, diffuse large B-cell lymphoma, and related malignancies .
Cat. No.: HY-P99506
CAS No.: 2148325-59-9
Synonyms: SC-003 mAb; SC-Mab003; SC34.28ss1
Target:
Research Areas:
Cat. No.: HY-RS08182
Target:
Research Areas:
MBD2 Human Pre-designed siRNA Set A contains three designed siRNAs for MBD2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-179238
Target:
Research Areas:
CS-1-103 is a potent estrogen receptor (ER) TRACER (transcriptional regulation via active control of epigenetic reprogramming). CS-1-103 inhibits ER transcriptional activity with an EC50 of 0.36 μM by recruiting methyl-CpG binding domain protein 2 (MBD2), HDACs and the nucleosome remodeling and deacetylase (NuRD) complex. CS-1-103 can be used for breast and prostate cancer research .
Cat. No.: HY-RS08181
Target:
Research Areas:
MBD1 Human Pre-designed siRNA Set A contains three designed siRNAs for MBD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS08183
Target:
Research Areas:
MBD3 Human Pre-designed siRNA Set A contains three designed siRNAs for MBD3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS08184
Target:
Research Areas:
MBD4 Human Pre-designed siRNA Set A contains three designed siRNAs for MBD4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS08185
Target:
Research Areas:
MBD5 Human Pre-designed siRNA Set A contains three designed siRNAs for MBD5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS08186
Target:
Research Areas:
MBD6 Human Pre-designed siRNA Set A contains three designed siRNAs for MBD6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19351
Target:
Research Areas:
Mbd3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mbd3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS22228
Target:
Research Areas:
Mbd1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mbd1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS22229
Target:
Research Areas:
Mbd5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mbd5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24283
Target:
Research Areas:
Mbd2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mbd2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25842
Target:
Research Areas:
Mbd3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mbd3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS28751
Target:
Research Areas:
Mbd5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mbd5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19187
Target:
Research Areas:
Dpep1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dpep1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17814
Target:
Research Areas:
Mbd2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mbd2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19616
Target:
Research Areas:
Mbd4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mbd4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
