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Metolachlor

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By Targets:	Environmental Pollutants (2) Estrogen Receptor/ERR (2) FXR (2) Glutathione S-transferase (3) Herbicide (4) Isotope-Labeled Compounds (7) Pregnane X Receptor (PXR) (2) Reference Standards (2)
By Research Areas:	Cancer (1) Metabolic Disease (1)

Inhibitors & Agonists

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1871S

Metolachlor-d6	Isotope-Labeled Compounds	Others
Metolachlor-d₆ is the deuterium labeled Metolachlor . Metolachlor is a pre-emergent selective, chloroacetanilide herbicide for the control of a variety of annual grass and broad leaf weeds in corn and other crops. Metolachlor is a chiral herbicide consisting of four stereoisomers .

HY-B1871

*Metolachlor*	Environmental Pollutants Herbicide	Others
Metolachlor is a pre-emergent selective, chloroacetanilide herbicide for the control of a variety of annual grass and broad leaf weeds in corn and other crops. Metolachlor is a chiral herbicide consisting of four stereoisomers .

HY-W020788

Benoxacor CGA 154281	Environmental Pollutants Glutathione S-transferase Estrogen Receptor/ERR Pregnane X Receptor (PXR) FXR	Metabolic Disease Cancer
Benoxacor (CGA 154281) is a herbicide safener and xenobiotic metabolism regulator. Benoxacor protects maize from the toxicity of metolachlor mainly by inducing detoxifying enzymes such as Glutathione S-transferase. Benoxacor also activates FXR, PXR and ERRα, and inhibits aromatase (aromatase). However, Benoxacor exhibits potential subacute oral toxicity and a high risk of hepatotoxicity in animal models. Benoxacor induces reactive oxygen species accumulation, interferes with embryonic heart development, and causes increased liver and kidney weights as well as alterations in gut microbiota in mice. Benoxacor can be used in studies related to hepatic steatosis, infertility, breast cancer and developmental toxicity .

HY-W681867

Fluxofenim CGA-133205	Herbicide Glutathione S-transferase	Others
Fluxofenim (CGA-133205) is a herbicide safener, with activity against Pyroxasulfone (HY-136633) and Metolachlor (HY-B1871). Fluxofenim enhances the activity of needle glutathione S-transferase (GST) towards the substrate 1-chloro-2,4-dinitrobenzene (CDNB) .

HY-B1871R

Metolachlor (Standard)	Herbicide Reference Standards	Others
Metolachlor (Standard) is the analytical standard of Metolachlor. This product is intended for research and analytical applications. Metolachlor is a pre-emergent selective, chloroacetanilide herbicide for the control of a variety of annual grass and broad leaf weeds in corn and other crops. Metolachlor is a chiral herbicide consisting of four stereoisomers .

HY-W713975

Metolachlor-d11	Isotope-Labeled Compounds Herbicide	Others
Metolachlor-d₁₁ is the deuterium labeled Metolachlor (HY-B1871). Metolachlor is a pre-emergent selective, chloroacetanilide herbicide for the control of a variety of annual grass and broad leaf weeds in corn and other crops. Metolachlor is a chiral herbicide consisting of four stereoisomers .

HY-W020788R

Benoxacor (Standard) CGA 154281 (Standard)	Reference Standards Glutathione S-transferase Estrogen Receptor/ERR Pregnane X Receptor (PXR) FXR	Others
Benoxacor (Standard) is the analytical standard of Benoxacor. This product is intended for research and analytical applications. Benoxacor (CGA 154281) is a herbicide safener and xenobiotic metabolism regulator. Benoxacor protects maize from the toxicity of metolachlor mainly by inducing detoxifying enzymes such as Glutathione S-transferase. Benoxacor also activates FXR, PXR and ERRα, and inhibits aromatase (aromatase). However, Benoxacor exhibits potential subacute oral toxicity and a high risk of hepatotoxicity in animal models. Benoxacor induces reactive oxygen species accumulation, interferes with embryonic heart development, and causes increased liver and kidney weights as well as alterations in gut microbiota in mice. Benoxacor can be used in studies related to hepatic steatosis, infertility, breast cancer and developmental toxicity .

HY-W714694

Metolachlor ESA Sodium Salt-d6	Isotope-Labeled Compounds	Others
Metolachlor ESA Sodium Salt-d₆ is the deuterium labeled Sodium 2-((2-ethyl-6-methylphenyl)(1-methoxypropan-2-yl)amino)-2-oxoethane-1-sulfonate (HY-W714198).

HY-W714168S

*(rac)-Metolachlor* metabolite CGA 351916-d3**	Isotope-Labeled Compounds	Others
(rac)-Metolachlor metabolite CGA 351916-d₃ is deuterium labeled 2-((2-Ethyl-6-methylphenyl)(1-methoxypropan-2-yl)amino)-2-oxoacetic acid .

HY-W722289S

*(rac)-Metolachlor* metabolite CGA 50267-d3** N-(2-(Ethyl-2,2,2-d₃)-6-methylphenyl)-2-aminopropanoic acid	Isotope-Labeled Compounds	Others
(rac)-Metolachlor metabolite CGA 50267-d₃ (N-(2-(Ethyl-2,2,2-d₃)-6-methylphenyl)-2-aminopropanoic acid) is deuterium labeled (2-Ethyl-6-methylphenyl)alanine .

HY-W289054S

*(S)-Metolachlor* metabolite CGA 50720-d3** 2-((2-(Ethyl-2,2,2-d₃)-6-methylphenyl)amino)-2-oxoacetic acid	Isotope-Labeled Compounds	Others
(S)-Metolachlor metabolite CGA 50720-d₃ (2-((2-(Ethyl-2,2,2-d₃)-6-methylphenyl)amino)-2-oxoacetic acid) is deuterium labeled 2-((2-Ethyl-6-methylphenyl)amino)-2-oxoacetic acid .

HY-W714705S

*(S)-Metolachlor* metabolite CGA 368208-d3 sodium salt** Sodium 2-((2-(ethyl-2,2,2-d₃)-6-methylphenyl)amino)-2-oxoethane-1-sulfonate	Isotope-Labeled Compounds	Others
(S)-Metolachlor metabolite CGA 368208-d₃ sodium salt (Sodium 2-((2-(ethyl-2,2,2-d₃)-6-methylphenyl)amino)-2-oxoethane-1-sulfonate) is deuterium labeled Sodium 2-((2-ethyl-6-methylphenyl)amino)-2-oxoethane-1-sulfonate .

Cat. No.	Product Name	Chemical Structure

HY-B1871S

Metolachlor-d6
Metolachlor-d₆ is the deuterium labeled Metolachlor . Metolachlor is a pre-emergent selective, chloroacetanilide herbicide for the control of a variety of annual grass and broad leaf weeds in corn and other crops. Metolachlor is a chiral herbicide consisting of four stereoisomers .

HY-W713975

Metolachlor-d11
Metolachlor-d₁₁ is the deuterium labeled Metolachlor (HY-B1871). Metolachlor is a pre-emergent selective, chloroacetanilide herbicide for the control of a variety of annual grass and broad leaf weeds in corn and other crops. Metolachlor is a chiral herbicide consisting of four stereoisomers .

HY-W714694

Metolachlor ESA Sodium Salt-d6
Metolachlor ESA Sodium Salt-d₆ is the deuterium labeled Sodium 2-((2-ethyl-6-methylphenyl)(1-methoxypropan-2-yl)amino)-2-oxoethane-1-sulfonate (HY-W714198).

HY-W714168S

*(rac)-Metolachlor* metabolite CGA 351916-d3**
(rac)-Metolachlor metabolite CGA 351916-d₃ is deuterium labeled 2-((2-Ethyl-6-methylphenyl)(1-methoxypropan-2-yl)amino)-2-oxoacetic acid .

HY-W722289S

*(rac)-Metolachlor* metabolite CGA 50267-d3**
(rac)-Metolachlor metabolite CGA 50267-d₃ (N-(2-(Ethyl-2,2,2-d₃)-6-methylphenyl)-2-aminopropanoic acid) is deuterium labeled (2-Ethyl-6-methylphenyl)alanine .

HY-W289054S

*(S)-Metolachlor* metabolite CGA 50720-d3**
(S)-Metolachlor metabolite CGA 50720-d₃ (2-((2-(Ethyl-2,2,2-d₃)-6-methylphenyl)amino)-2-oxoacetic acid) is deuterium labeled 2-((2-Ethyl-6-methylphenyl)amino)-2-oxoacetic acid .

HY-W714705S

*(S)-Metolachlor* metabolite CGA 368208-d3 sodium salt**
(S)-Metolachlor metabolite CGA 368208-d₃ sodium salt (Sodium 2-((2-(ethyl-2,2,2-d₃)-6-methylphenyl)amino)-2-oxoethane-1-sulfonate) is deuterium labeled Sodium 2-((2-ethyl-6-methylphenyl)amino)-2-oxoethane-1-sulfonate .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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