12 Results for "

Mevalonolactone

" in MedChemExpress (MCE) Product Catalog:
Products (12)

12 Results for "Mevalonolactone" in MCE Product Catalog:

1
DL-Mevalonolactone
DL-Mevalonolactone
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1 Cited Publications
Cat. No.: HY-107855
CAS No.: 674-26-0
Purity:  99.15%
Synonyms: (±)-Mevalonolactone; Mevalolactone
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite

DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy . DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling [2][4].
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Mevalonolactone
Mevalonolactone
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Cat. No.: HY-135700
CAS No.: 19115-49-2
Purity:  ≥98.0%
Category:  

Microorganisms Other Phenylpropanoids Phenylpropanoids

Target:  

Calcineurin Ras HMG-CoA Reductase (HMGCR)

Mevalonolactone is an intermediate metabolite in the eukaryotic mevalonate pathway, serving as the stable δ-lactone form of mevalonate with oral activity. Mevalonolactone exhibits binding affinity for ZNF384 (Ka = 12.6 μM) and inhibitory activity against aconitase (aconitase). Mevalonolactone promotes the nuclear localization of ZNF384 and enhances its binding to the GGPPS promoter. Mevalonolactone induces insulin resistance, disrupts glucose and lipid metabolism, enhances the isoprenylation of K-Ras, and inhibits the activation of the insulin signaling pathway. Mevalonolactone inhibits polypeptide synthesis of HMG-CoA reductase in isolated rat hepatocytes, promotes its degradation, and reduces its enzymatic activity. Mevalonolactone impairs mitochondrial function in rat brains. Mevalonolactone promotes the development of metabolically unhealthy obesity. Mevalonolactone can be used in research related to metabolically abnormal obesity, mevalonic aciduria, HMGCR-related limb-girdle myopathy, and statin-induced myopathy .
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Coibamide A
Coibamide A
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Cat. No.: HY-P3990
CAS No.: 1029227-48-2
Target:  

VEGFR Autophagy Apoptosis

Research Areas:  

Cancer

Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, shows potent antiproliferative activity. Coibamide A induces autophagosome accumulation via an mTOR-independent mechanism. Coibamide A induces apoptosis. Coibamide A inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts .
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DL-Mevalonolactone-d7
DL-Mevalonolactone-d7
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Cat. No.: HY-107855S
CAS No.: 347840-19-1
Purity:  99.27%
Synonyms: (±)-Mevalonolactone-d7; Mevalolactone-d7
DL-Mevalonolactone-d7 is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (?Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling .
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DL-Mevalonolactone (Standard)
DL-Mevalonolactone (Standard)
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Cat. No.: HY-107855R
CAS No.: 674-26-0
Synonyms: (±)-Mevalonolactone (Standard); Mevalolactone (Standard)
Category:  

Natural Products Endogenous metabolite

Target:  

Endogenous Metabolite Reference Standards

DL-Mevalonolactone (Standard) is the analytical standard of DL-Mevalonolactone. This product is intended for research and analytical applications. DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy . DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling .
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DL-Mevalonolactone-d3
DL-Mevalonolactone-d3
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Cat. No.: HY-107855S1
CAS No.: 61219-76-9
Synonyms: (±)-Mevalonolactone-d3; Mevalolactone-d3
DL-Mevalonolactone-d3 is the deuterium labeled DL-Mevalonolactone . DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential ( Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling .
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Telomycin
Telomycin
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Cat. No.: HY-P1720
CAS No.: 19246-24-3
Target:  

Antibiotic Bacterial

Research Areas:  

Infection

Telomycin is a calcium-dependent antibiotic, which can be produced by Streptomyces. Telomycin inhibits gram-positive bacteria, including multidrug-resistant (MDR) pathogens .
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DL-Mevalonolactone-d4
DL-Mevalonolactone-d4
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Cat. No.: HY-W752587
CAS No.: 349553-98-6
Synonyms: (±)-Mevalonolactone-d4; Mevalolactone-d4
DL-Mevalonolactone-d4 ( (±)-Mevalonolactone-d4) is the deuterium labeled DL-Mevalonolactone (HY-107855). DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy . DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling .
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DL-Mevalonolactone-13C
DL-Mevalonolactone-13C
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Cat. No.: HY-107855S2
CAS No.: 53771-22-5
Synonyms: (±)-Mevalonolactone-13C; Mevalolactone-13C
DL-Mevalonolactone- 13C ((±)-Mevalonolactone- 13C) is the 13C-labeled DL-Mevalonolactone (HY-107855). DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy. DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling.
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DL-Mevalonolactone-13C2
DL-Mevalonolactone-13C2
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Cat. No.: HY-107855S4
CAS No.: 287111-36-8
Synonyms: (±)-Mevalonolactone-13C2; Mevalolactone-13C2
DL-Mevalonolactone- 13C2 ((±)-Mevalonolactone- 13C2) is the 13C-labeled DL-Mevalonolactone (HY-107855). DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy . DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling [2][4].
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Protactin
Protactin
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Cat. No.: HY-P1709
CAS No.: 141912-59-6
Category:  

Microorganisms Antibiotics Other Antibiotics

Target:  

Bacterial

Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model .
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TL-119
TL-119
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Cat. No.: HY-P11022
CAS No.: 55599-68-3
Synonyms: A-3302-B
Target:  

Endogenous Metabolite HSV TRP Channel

Research Areas:  

Infection Cancer

TL-119 (A-3302-B) is a polypeptide. TL-119 can be isolated from the bacteria Micromonospora sp. MAG 9-7 and Saccharomonospora sp. CNQ-490. TL-119 inhibits TRPV-1. TL-119 exhibits antiviral activity against HSV-2. TL-119 possesses anticancer activity against gastric cancer and colorectal cancer .
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