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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
40 Results for "
NAK
" in MedChemExpress (MCE) Product Catalog:
Products (40)
40 Results for "NAK" in MCE Product Catalog:
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Soraprazan (BYK61359) is a selective, reversible K-competitive inhibitor of the H,K-ATPase (Ki=6.4 nM), with an IC50 of 0.19 μM in gastric glands. Soraprazan binds to the H,K-ATPase with a Kd of 28.27 nM. Soraprazan shows immediate inhibition of acid secretion and is more than 2000-fold selective for H,K-ATPase over Na,K- and Ca-ATPases .
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Calphostin C is a highly selective PKC inhibitor (IC50=0.05 μM) and tumor apoptosis inducer. Calphostin C competitively binds to PKC and inhibits PKC-mediated phosphorylation signal transduction. Calphostin C restores Na+/K+ ATPase activity in the sciatic nerve of diabetic mice and improves neuropathy. Calphostin C can be used in the study of anti-tumor and diabetic complications .
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1 Cited Publications
Cat. No.: HY-N1446S2
CAS No.: 287100-82-7
Synonyms: 9-cis-Octadecenoic acid-13C18; 9Z-Octadecenoic acid-13C18
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1 Cited Publications
Cat. No.: HY-N1446S1
CAS No.: 5711-29-5
Synonyms: 9-cis-Octadecenoic acid-d2; 9Z-Octadecenoic acid-d2
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1 Cited Publications
Category:
Cardiovascular Disease Neurological Disease Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Phenylpropanoids Plants Disease Research Fields
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1 Cited Publications
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GAK inhibitor 49 is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 also shows binding to RIPK2 .
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1 Cited Publications
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GAK inhibitor 49 hydrochloride is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 hydrochloride also shows binding to RIPK2 .
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1 Cited Publications
Cat. No.: HY-P86665
Synonyms: ATP1A1; alpha 1 Sodium Potassium ATPase; A1A1; AT1A1; AT1A1_HUMAN; Atpa-1; ATPase Na+/K+transporting alpha 1 polypeptide; ATPase Na+/K+transporting subunit alpha 1; BC010319; EC 3.6.3.9; MGC3285; MGC38419; MGC51750; Na K ATPase alpha A catalytic polypeptide; Na K ATPase catalytic subunit alpha A protein; Na(+)/K(+) ATPase 1; Na(+)/K(+) ATPase alpha-1 subunit; Na+, K+ATPase alpha subunit; Na+/K+ATPase alpha 1 subunit; Na+/K+ATPase 1; Na, K ATPase alpha 1 subunit; Nkaa1b; Sodium potassium ATPase alpha 1 polypeptide; Sodium pump 1; Sodium pump subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-1; Sodium/potassium-transporting ATPase subunit alpha-1.
Cat. No.: HY-N1446S5
CAS No.: 2687960-84-3
Synonyms: 9-cis-Octadecenoic acid-d9; 9Z-Octadecenoic acid-d9
Cat. No.: HY-N1446S
CAS No.: 82005-44-5
Synonyms: 9-cis-Octadecenoic acid-13C; 9Z-Octadecenoic acid-13C
Cat. No.: HY-W754708
CAS No.: 508-52-1
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Cat. No.: HY-B0135S
CAS No.: 1189482-35-6
Synonyms: 9-cis-Octadecenoic acid (Standard); 9Z-Octadecenoic acid (Standard)
Cat. No.: HY-N1446S3
CAS No.: 223487-44-3
Synonyms: 9-cis-Octadecenoic acid-d17; 9Z-Octadecenoic acid-d17
Cat. No.: HY-147083
CAS No.: 2242913-80-8
SGC-AAK1-1N is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor, with an IC50 of 1.8 μM .
Cat. No.: HY-N1446S4
CAS No.: 2483735-58-4
Synonyms: 9-cis-Octadecenoic acid-13C-1; 9Z-Octadecenoic acid-13C-1
Cat. No.: HY-N1446BR
CAS No.: 143-19-1
Synonyms: Sodium oleate (Standard); 9-cis-Octadecenoic acid sodium (Standard); 9Z-Octadecenoic acid sodium (Standard)
Cat. No.: HY-124742
CAS No.: 248281-68-7
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AR-HO47108 is an orally active reversible Na+/K+ ATPase inhibitor. AR-HO47108 reversibly blocks the final step of gastric acid secretion by competitively binding to the potassium ion binding site of the Na+/K+ ATPase in the gastric wall cells. AR-HO47108 can be used for research on diseases related to excessive gastric acid secretion, such as peptic ulcers .
Cat. No.: HY-105431
CAS No.: 59006-00-7
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ASI-222 is an aminosugar cardiac glycoside. ASI-222 can inhibit Na+/K+ ATPase and show positive inotropic effect. ASI-222 can be used for the research of cardiovascular disease .
Cat. No.: HY-165407
CAS No.: 99453-84-6
Research Areas:
Neltenexine, a mucolytic agent, is an Elastase inhibitor. Neltenexine diminishes anion secretion in in bronchial epithelial cells by inhibiting the Cl− and HCO3- uptake via Na/K/2Cl++− and Na+/HCO3- cotransporter without blockade of the CFTR channel, and also diminishes anion secretion via stimulation of Cl−/HCO3- exchanger. Neltenexine significantly prevents pulmonary emphysema with a reduction of alveolar deformation in rat models induced by Elastase. Neltenexine can be used for lung diseases such as chronic obstructive pulmonary disease (COPD) research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
