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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
NDRG1
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "NDRG1" in MCE Product Catalog:
5
5 Cited Publications
Synonyms: SGK3-PROTAC1
PROTAC SGK3 degrader-1 (SGK3-PROTAC1), a chemical probe, is a von Hippel-Lindau ligand-based SKG3 PROTAC composed of a PEG3-C4-OBn (HY-130620) alkyl linker, an SGK3 degrader (red structure), and a VHL ligand (HY-150803, blue structure). PROTAC SGK3 degrader-1 (0.3 μM) induced 50% endogenous SGK3 degradation within 2 hours, and 80% SGK3 degradation was observed at 8 hours, accompanied by loss of phosphorylation of NDRG1 (SGK3 substrate) [1].
1
1 Cited Publications
HaloPROTAC-E is a SGK3/VPS34 HaloPROTAC degrader that degrades Halo-tagged SGK3 and VPS34, with a DC50 of 3-10 nM in HEK293 cells. HaloPROTAC-E induces ubiquitination and proteasomal degradation of target proteins. HaloPROTAC-E blocks downstream phosphorylation of SGK3 substrate NDRG1. HaloPROTAC-E is applicable for cancer research [1].
1
1 Cited Publications
Research Areas:
MAX-40279 is a dual and orally active inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 is also effective against the FLT3 mutants such as FLT3 D835Y, suggesting that it can overcome resistance to Quizartinib (HY-13001) and Sorafenib (HY-10201). MAX-40279 inhibits NDRG1 phosphorylation at Ser330 and suppresses endothelial-to-mesenchymal transition (EndMT). MAX-40279 can be used for the research of acute myelogenous leukemia (AML) [1] .
1
1 Cited Publications
Research Areas:
MAX-40279 hemiadipate is a dual and orally active inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 hemiadipate is also effective against the FLT3 mutants such as FLT3 D835Y, suggesting that it can overcome resistance to Quizartinib (HY-13001) and Sorafenib (HY-10201). MAX-40279 hemiadipate inhibits NDRG1 phosphorylation at Ser330 and suppresses endothelial-to-mesenchymal transition (EndMT). MAX-40279 hemiadipate can be used for the research of acute myelogenous leukemia (AML) [1] .
1
1 Cited Publications
Research Areas:
MAX-40279 hemifumarate is a dual and orally active inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 hemifumarate is also effective against the FLT3 mutants such as FLT3 D835Y, suggesting that it can overcome resistance to Quizartinib (HY-13001) and Sorafenib (HY-10201). MAX-40279 hemifumarate inhibits NDRG1 phosphorylation at Ser330 and suppresses endothelial-to-mesenchymal transition (EndMT). MAX-40279 hemifumarate can be used for the research of acute myelogenous leukemia (AML) [1] .
Cat. No.: HY-RS17382
Target:
Research Areas:
Ndrg1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ndrg1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09114
Target:
Research Areas:
NDRG1 Human Pre-designed siRNA Set A contains three designed siRNAs for NDRG1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23837
Target:
Research Areas:
Ndrg1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ndrg1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-145723A
CAS No.: 2388506-51-0
Research Areas:
MAX-40279 hydrochloride is a dual and orally active inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 hydrochloride is also effective against the FLT3 mutants such as FLT3 D835Y, suggesting that it can overcome resistance to Quizartinib (HY-13001) and Sorafenib (HY-10201). MAX-40279 hydrochloride inhibits NDRG1 phosphorylation at Ser330 and suppresses endothelial-to-mesenchymal transition (EndMT). MAX-40279 hydrochloride can be used for the research of acute myelogenous leukemia (AML) [1] .
Cat. No.: HY-P70886
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NDRG1; Protein NDRG1; Prev. CAP43; Protein Regulated By Oxygen-1; DRG1; PROXY1; RTP; CMT4D; TDD5; HMSNL; NDR1; RIT42; Reducing Agents And Tunicamycin-Responsive Protein; TARG1; N-Myc Downstream-Regulated Gene 1 Protein; Rit42; Nickel-Specific Induction Pr
Species:
Human
Source:
E. coli
Cat. No.: HY-P80239
Synonyms: CAP43, DRG1, RTP, NDRG1, Protein NDRG1, Differentiation-related gene 1 protein, N-myc downstream-regulated gene 1 protein, Nickel-specific induction protein Cap43, Reducing agents and tunicamycin-responsive protein, Rit42, DRG-1
Cat. No.: HY-187958
CAS No.: 91837-56-8
Target:
Research Areas:
PO-322 is a selective SGK1 inhibitor with an IC50 of 54 nM. PO-322 reduces NDRG1 phosphorylation through inhibition of SGK1. PO-322 inhibits T cell proliferation and the production of IL-17, IFN-γ, and IL-6, accompanied by upregulated phosphorylation of p70S6K and STAT5. PO-322 exhibits immunosuppressive activity both in vitro and in vivo, and attenuates DNFB-induced delayed-type hypersensitivity and Imiquimod (HY-B0180)-induced psoriasis-like dermatitis. PO-322 is useful for research related to autoimmune diseases and psoriasis [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
