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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
NTCP
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "NTCP" in MCE Product Catalog:
8
Cat. No.: HY-156701
CAS No.: 1428988-21-9
Target:
Research Areas:
BAY-1128688 is a selective, orally active aldo-keto reductase family 1 member C3 (AKR1C3) inhibitor with an IC50 of 1.4 nM. BAY-1128688 inhibits OATP, BSEP, MRP4, NTCP, UGT1A1, MRP2, and MRP3. BAY-1128688 induces reactive oxygen species (ROS) production, inhibits the mitochondrial electron transport chain, and increases circulating androsterone, etiocholanolone, dihydrotestosterone, and serum bilirubin concentrations. BAY-1128688 alters bilirubin disposition, leading to elevated plasma bilirubin, independent of liver injury. BAY-1128688 can be used in research on endometriosis and polycystic ovary syndrome .
Cat. No.: HY-172835
Synonyms: JH-B10
Rapavir (JH-B10) is a selective and potent sodium taurocholate cotransporting polypeptide (NTCP) inhibitor with an IC50 value of 1.8 nM for the uptake of taurocholic acid-d4 (TCA-d4). Rapavir exerts antiviral activity by directly binding to NTCP and blocking the entry of the virus into cells during the HBV infection phase. Rapavir is promising for research of HBV infections .
Cat. No.: HY-174379
NTLiverTac PDE6D degrader-1 is a PDE6D NTLiverTac degrader with a DC50 of 4.09 μM. NTLiverTac PDE6D degrader-1 is formed by conjugating a PDE6D PROTAC degrader with the NTCP ligand Cholic acid (HY-N0324). NTLiverTac PDE6D degrader-1 triggers the ubiquitin-proteasome system-mediated degradation process by forming a complex with PDE6D and MDM2, inducing proteasome-dependent and NTCP-dependent degradation. NTLiverTac PDE6D degrader-1 inhibits PDE6D-dependent KRAS trafficking and suppresses KRAS-related oncogenic signaling cascades. NTLiverTac PDE6D degrader-1 inhibits the activation of the PI3K/AKT/mTOR signaling pathway and induces cellular Apoptosis. NTLiverTac PDE6D degrader-1 enters cancer cells via NTCP-mediated endocytosis. NTLiverTac PDE6D degrader-1 can be used in the research of hepatoblastoma (MDM2 ligand: (4R,5S)-Nutlin carboxylic acid (HY-128836); NTCP ligand: Cholic acid (HY-N0324); PDE6D ligand: Sorafenib (HY-10201)) .
Cat. No.: HY-W702907
CAS No.: 1346599-56-1
Target:
Research Areas:
DM-4103 is a major metabolite of Tolvaptan (HY-17000) that is metabolized primarily by the CYP3A4 enzyme in the liver. DM-4103 inhibits the ability of human liver transporters NTCP, BSEP, MRP2, MRP3, MRP4 (IC50 values are 16.3, 4.15, 51.0, 44.6, 4.26 μM, respectively) and bile acid transport in SCHH cells. DM-4103 can be used in the study of autosomal dominant polycystic kidney disease (ADPKD) .
Cat. No.: HY-RS22028
Target:
Research Areas:
Slc10a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Slc10a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS28546
Target:
Research Areas:
Slc10a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Slc10a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-179265
D-CAM-14 is a potent HBV capsid assembly modulator with potent anti-HBV activity (EC50 = 0.1 nM, EC90 = 9 nM in HepAD38 cells). D-CAM-14 suppresses HBeAg, and HBcAg in HBV-infected HepG2-NTCP cells, with EC50 values of 98 and 67 nM, respectively. D-CAM-14 has distinct impacts on capsid radii and the morphology of preassembled capsids. D-CAM-14 can be used for HBV infection disease research .
Cat. No.: HY-168524
CAS No.: 898440-60-3
Target:
Research Areas:
SOAT-IN-1 (compound 40) is a potent and selective sodium-dependent organic anion transporter (SOAT) inhibitor with IC50 values of 1.6, 14.3 µM for SOAT, NTCP, respectively .
Cat. No.: HY-170605
CAS No.: 1362113-74-3
BA-AZT1 is the inhibitor for HBV polymerase and sodium taurocholate cotransporting polypeptide (NTCP). BA-AZT1 inhibits the secretion of viral capsid protein HBsAg and HBeAg with IC50 of 0.65 µM and 13.42 µM, inhibits the HBV DNA replication with an IC50 of 0.70 µM .
Cat. No.: HY-W702908
CAS No.: 1346599-75-4
Target:
Research Areas:
DM-4107 is a major metabolite of Tolvaptan (HY-17000) that is metabolized primarily by the CYP3A4 enzyme in the liver. DM-4107 inhibits the ability of human liver transporters NTCP, BSEP, MRP3, MRP4 (IC50 values are 95.6, 119, 61.2, 37.9 μM, respectively) and bile acid transport in SCHH cells. DM-4107 can be used in the study of autosomal dominant polycystic kidney disease (ADPKD) .
Cat. No.: HY-P703212
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SLC10A1; NTCP1; Solute Carrier Family 10 Member 1; Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 1; NTCP; Na+/Taurocholate Cotransporting Polypeptide; Sodium/Taurocholate Cotransporting Polypeptide; Na/Taurocholate Cotransportin
Species:
Human
Source:
HEK293
Cat. No.: HY-115668
CAS No.: 956944-02-8
NPD8716 is a sodium taurocholate cotransporting polypeptide (NTCP) inhibitor with a human IC50 of 17.8 μM. NPD8716 interacts with NTCP, blocks the binding of HBV preS1 to NTCP, impairs NTCP-mediated bile acid uptake, inhibits NTCP transporter activity, and blocks the attachment of viruses to host hepatocytes. NPD8716 inhibits the entry of HBV and HDV into host cells. NPD8716 can be used in studies related to hepatitis B virus infection and hepatitis D virus infection .
Cat. No.: HY-RS12985
Target:
Research Areas:
SLC10A1 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC10A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P811318
Synonyms: NTCP, GIG29, SLC10A1, Hepatic sodium/bile acid cotransporter, Cell growth-inhibiting gene 29 protein, Na(+)/bile acid cotransporter, Na(+)/taurocholate transport protein, Sodium/taurocholate cotransporting polypeptide, Solute carrier family 10 member 1
Cat. No.: HY-186131
CAS No.: 1640013-00-8
Target:
Research Areas:
Val-CDCA is a chenodeoxycholate (CDCA) and C-24 L-Valine (HY-N0717) conjugate. Val-CDCA inhibits taurocholate uptake in human NTCP-stably transfected HEK293 cells. Val-CDCA can be used for HBV infection .
Cat. No.: HY-P705614
Purity: Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: SLC10A2; Na+/Taurocholate Cotransporting Polypeptide 2; Prev. ASBT; Ileal Sodium/Bile Acid Cotransporter; Prev. ISBT; Ileal Bile Acid Transporter; NTCP2; Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 2; IBAT; Ileal Apical Sodium
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
