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Nucleotide pyrophosphatase/phosphodiesterase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Phosphodiesterase (PDE) (11) NTPDase (1)
By Research Areas:	Cancer (11) Infection (4) Inflammation/Immunology (1) Metabolic Disease (1)

Inhibitors & Agonists

Antibodies

Targets Recommended: Phosphodiesterase (PDE) HCN Channel SOS1

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-129490

Enpp-1-IN-1 3 Publications Verification	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-1 is an effective selective enpp-1 (nucleotide pyrophosphatase-phosphodiesterase 1) inhibitor .

HY-143256

Enpp-1-IN-12	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-12 (compound 43) is a potent and orally active *ecto-nucleotide* pyrophosphatase/phosphodiesterases 1 (ENPP1)** inhibitor, with a Ki of 41 nM. Enpp-1-IN-12 exhibits anti-tumor activity .

HY-158791

Enpp-1-IN-21	Phosphodiesterase (PDE)	Metabolic Disease Cancer
Enpp-1-IN-21 (compound 4g) is an inhibitor of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), with IC₅₀ values for ENPP1 and ENPP3 at 0.45 and 0.19 μM, respectively .

HY-143254

Enpp-1-IN-10	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-10 (compound 1) is a potent *Ecto-nucleotide* pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor with an K_i** value of 3.866 μM. Enpp-1-IN-10 can be used for researching anticancer .

HY-143255

Enpp-1-IN-11	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-11 (compound 23) is a potent *Ecto-nucleotide* pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor with an K_i** value of 45 nM. Enpp-1-IN-11 exhibits low clearance in human and mouse liver microsomes, good plasma stability in human and mouse plasma. Enpp-1-IN-11 can be used for researching anticancer .

HY-145065

Enpp-1-IN-7	Phosphodiesterase (PDE)	Infection Cancer
Enpp-1-IN-7 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-7 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51) .

HY-145064

Enpp-1-IN-6	Phosphodiesterase (PDE)	Infection Cancer
Enpp-1-IN-6 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-6 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51) .

HY-145070

Enpp-1-IN-9	Phosphodiesterase (PDE)	Infection Cancer
Enpp-1-IN-9 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-9 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51) .

HY-145069

Enpp-1-IN-8	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-8 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-8 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51) .

HY-145063

Enpp-1-IN-5	Phosphodiesterase (PDE)	Infection Inflammation/Immunology Cancer
Enpp-1-IN-5 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-5 has the potential for the research of cancer and infectious diseases (extracted from patent WO2019046778A1/WO2021203772A1, compound 1) .

HY-181981

NTPDase/NPP1-IN-1	NTPDase Phosphodiesterase (PDE)	Cancer
NTPDase/NPP1-IN-1 is an ectonucleotidase (NTPDase) and nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) inhibitor, with IC₅₀ values of 0.28, 0.92, 0.82 and 0.73 μM against h-NTPDase1, h-NTPDase2, h-NTPDase3 and h-NPP1, respectively. NTPDase/NPP1-IN-1 is a membrane-interacting agent that localizes to the plasma membrane and interacts with cancer cells. NTPDase/NPP1-IN-1 can be used in the research of breast cancer .

Cat. No.	Compare	상품명	Application	Reactivity	Image

HY-P810389

	ENPP3 Antibody (YA9706) Alkaline phosphodiesterase I, ARHR2, B10, CD203c, CD203c antigen, dJ1005H11.3 (phosphodiesterase I/Nucleotide pyrophosphatase 3), dJ914N13.3 (phosphodiesterase I/Nucleotide pyrophosphatase 3), E NPP 3, E-NPP 3, EctoNucleotide pyrophosphatase/phosphodiesterase 3	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	ENPP3 Antibody (YA9706) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to ENPP3.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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