Enpp-1-IN-11
Enpp-1-IN-11 (compound 23) is a potent Ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor with an Ki value of 45 nM. Enpp-1-IN-11 exhibits low clearance in human and mouse liver microsomes, good plasma stability in human and mouse plasma. Enpp-1-IN-11 can be used for researching anticancer.
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- CAS. Nr.: 2631703-04-1
- Formel: C14H14N6O3S
- Molecular Weight:346.36
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
Ki: 45 nM (ENPP1)[1]
In Vivo
Pharmacokinetic Parameters of Enpp-1-IN-11 in female BALB/c mice[1].
| PO (10 mg/kg) | IV (1 mg/kg) | |
| Tmax (h) | 1.2 | |
| Cmax (ng/mL) | 33.10 | 1600.20 |
| C0 (ng/mL) | 4546.51 | |
| Tmax (h) | 0.50 | 0.08 |
| AUClast (ng/mL·h) | 29.47 | 404.40 |
| AUCinf (ng/mL·h) | 31.78 | 415.55 |
| AUCextrap (%) | 7.26 | 2.68 |
| t1/2 (h) | 0.54 | 0.11 |
| MRTlast (h) | 0.66 | 0.07 |
| CL (mL/min/kg) | 40.10 | |
| VSS (L/kg) | 0.22 | |
| F (%) | <1 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2631703-04-1
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Molecular Weight 346.36
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Formel C14H14N6O3S
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SMILES
O=C(NC1=CC=C(O)C(OC)=C1)CSC2=NC(N)=NC3=C2NC=N3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Enpp-1-IN-11 Related Classifications
HY-143255 Related Classifications
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