Enpp-1-IN-11
Enpp-1-IN-11 (compound 23) is a potent Ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor with an Ki value of 45 nM. Enpp-1-IN-11 exhibits low clearance in human and mouse liver microsomes, good plasma stability in human and mouse plasma. Enpp-1-IN-11 can be used for researching anticancer.
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- CAS No.: 2631703-04-1
- 화학식: C14H14N6O3S
- 분자량:346.36
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
Ki: 45 nM (ENPP1)[1]
In Vivo
Pharmacokinetic Parameters of Enpp-1-IN-11 in female BALB/c mice[1].
| PO (10 mg/kg) | IV (1 mg/kg) | |
| Tmax (h) | 1.2 | |
| Cmax (ng/mL) | 33.10 | 1600.20 |
| C0 (ng/mL) | 4546.51 | |
| Tmax (h) | 0.50 | 0.08 |
| AUClast (ng/mL·h) | 29.47 | 404.40 |
| AUCinf (ng/mL·h) | 31.78 | 415.55 |
| AUCextrap (%) | 7.26 | 2.68 |
| t1/2 (h) | 0.54 | 0.11 |
| MRTlast (h) | 0.66 | 0.07 |
| CL (mL/min/kg) | 40.10 | |
| VSS (L/kg) | 0.22 | |
| F (%) | <1 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2631703-04-1
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분자량 346.36
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화학식 C14H14N6O3S
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SMILES
O=C(NC1=CC=C(O)C(OC)=C1)CSC2=NC(N)=NC3=C2NC=N3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Enpp-1-IN-11 Related Classifications
HY-143255 Related Classifications
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