Enpp-1-IN-11
Enpp-1-IN-11 (compound 23) is a potent Ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor with an Ki value of 45 nM. Enpp-1-IN-11 exhibits low clearance in human and mouse liver microsomes, good plasma stability in human and mouse plasma. Enpp-1-IN-11 can be used for researching anticancer.
For research use only. We do not sell to patients.
- CAS No.: 2631703-04-1
- Formula: C14H14N6O3S
- Molecular Weight:346.36
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Ki: 45 nM (ENPP1)[1]
Pharmacokinetic Parameters of Enpp-1-IN-11 in female BALB/c mice[1].
| PO (10 mg/kg) | IV (1 mg/kg) | |
| Tmax (h) | 1.2 | |
| Cmax (ng/mL) | 33.10 | 1600.20 |
| C0 (ng/mL) | 4546.51 | |
| Tmax (h) | 0.50 | 0.08 |
| AUClast (ng/mL·h) | 29.47 | 404.40 |
| AUCinf (ng/mL·h) | 31.78 | 415.55 |
| AUCextrap (%) | 7.26 | 2.68 |
| t1/2 (h) | 0.54 | 0.11 |
| MRTlast (h) | 0.66 | 0.07 |
| CL (mL/min/kg) | 40.10 | |
| VSS (L/kg) | 0.22 | |
| F (%) | <1 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2631703-04-1
-
Molecular Weight 346.36
-
Formula C14H14N6O3S
-
SMILES
O=C(NC1=CC=C(O)C(OC)=C1)CSC2=NC(N)=NC3=C2NC=N3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Enpp-1-IN-11 Related Classifications
HY-143255 Related Classifications
Powered by Bioz