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P4H

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Collagen (1) TGF-β Receptor (1)
By Research Areas:	Cancer (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2589

Isosaponarin	TGF-β Receptor Collagen	Infection Metabolic Disease Inflammation/Immunology Cancer
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases collagen synthesis via up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects ^[4] .

Isosaponarin	Flavonoids Vaccaria segetalis (Neck.) Garcke Classification of Application Fields Flavones Other Diseases Phenols Polyphenols Plants Disease Research Fields Caryophyllaceae Source Classification	TGF-β Receptor Collagen
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases collagen synthesis via up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects ^[4] .

Host:	Mouse (2) Rabbit (3)
Reactivity:	Human (5) Rat (3) Mouse (3)
Application:	IHC-P (5) ICC/IF (1) IF-Tissue (1) IP (2) WB (3) FC (1)
Isotype:	IgG (3) IgG1 (2)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (3) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87578

	PHD1 Antibody (YA7262) DKFZp434E026 antibody; Egl nine homolog 2 antibody; EGLN 2 antibody; EIT 6 antibody; Estrogen-induced tag 6 antibody; HIF P4H 1 antibody; HIF prolyl hydroxylase 1 antibody; HIF-PH1 antibody; HIF-prolyl hydroxylase 1 antibody; HIFPH 1 antibody; HPH-3 antibody; HPH3 antibody; Hypoxia-inducible factor prolyl hydroxylase 1 antibody; P4H1 antibody; PHD 1 antibody; prolyl hydroxylase domain containing protein 1 antibody	WB, IHC-P, ICC/IF, FC, IF-Tissue	Human, Mouse, Rat
	PHD1 Antibody (YA7262) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PHD1.

HY-P83230

	HIF Prolyl Hydroxylases Antibody (YA2975) PH4; PH-4; PHD4; EGLN4; HIDEA; HIFPH4; P4H-TM	WB, IHC-P, IP	Human
	HIF Prolyl Hydroxylases Antibody (YA2975) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HIF Prolyl Hydroxylases.

HY-P83230A

	HIF Prolyl Hydroxylases Antibody (YA2975)(PBS only) PH4; PH-4; PHD4; EGLN4; HIDEA; HIFPH4; P4H-TM	WB, IHC-P, IP	Human
	HIF Prolyl Hydroxylases Antibody (YA2975) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HIF Prolyl Hydroxylases.

HY-P88144

	P4HA3 Antibody (YA7828) 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase); alpha III subunit; alpha polypeptide III; C-P4H alpha III; collagen prolyl 4-hydroxylase alpha(III); procollagen-proline; prolyl 4-hydroxylase	IHC-P	Human, Mouse, Rat
	P4HA3 Antibody (YA7828) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to P4HA3.

HY-P88144A

	P4HA3 Antibody (YA7828)(PBS only) 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase); alpha III subunit; alpha polypeptide III; C-P4H alpha III; collagen prolyl 4-hydroxylase alpha(III); procollagen-proline; prolyl 4-hydroxylase	IHC-P	Human, Mouse, Rat
	P4HA3 Antibody (YA7828) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to P4HA3.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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P4H

Inhibitors & Agonists

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Antibodies

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