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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
PACS1
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "PACS1" in MCE Product Catalog:
7
5
5 Cited Publications
Referencia número: HY-P0221
No. CAS: 137061-48-4
Synonyms: Pituitary Adenylate Cyclase Activating Polypeptide 38
Áreas de investigación:
3
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3
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2
2 Cited Publications
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PA-8 is a potent, selective and orally active PACAP type I (PAC1) receptor antagonist. PA-8 inhibits the phosphorylation of CREB induced by PACAP in PAC1-, but not VPAC1- or VPAC2-receptor. PA-8 also inhibits PACAP-induced cAMP elevation with an IC50 of 2 nM [1] .
1
1 Cited Publications
Synonyms: PAC1R antagonist 1
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PA-915 (PAC1R antagonist 1) is a potent and orally active antagonist of PAC1 receptor. PA-915 inhibits pituitary adenylate cyclase-activating polypeptide (PACAP)-induced CREB phosphorylation. PA-915 can inhibit PACAP- and nerve injury-induced allodynia. PA-915 can be used for the research of neuropathic pain [1].
Referencia número: HY-P99509
No. CAS: 2225850-33-7
Synonyms: AMG-301
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Referencia número: HY-P0221C
No. CAS: 129405-61-4
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Referencia número: HY-RS09955
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PACS1 Human Pre-designed siRNA Set A contains three designed siRNAs for PACS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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PA-9 is a pituitary adenylate cyclase-activating polypeptide (PACAP) type I (PAC1) receptor antagonist. PA-9 dose dependently inhibits PACAP-induced cAMP elevation with an IC50 of 5.6 nM. PA-9 can be used for the research of neuropathic and/or inflammatory pain [1].
Referencia número: HY-P3483
No. CAS: 135374-80-0
Áreas de investigación:
Referencia número: HY-13523S
No. CAS: 1287241-26-2
Synonyms: Procaspase activating compound 1-d8
Referencia número: HY-159632
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PAR4 antagonist 6 (Compound 12) is a PAR4 antagonist, with IC50 values of 134 and 401 nM for hPAR4 (PAC1) and mPAR4 (PAC1), respectively [1].
Referencia número: HY-119158
No. CAS: 1476847-58-1
Áreas de investigación:
VU0652925, an analog of BMS986120, is a PAR4 antagonist, with IC50 values of 43 pM and 39.2 pM for PAC1 and P-selectin, respectively. VU0652925 is able to suppress GPIIbIIIa activation [1].
Referencia número: HY-P1817
No. CAS: 144025-82-1
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Referencia número: HY-129937
No. CAS: 2738533-33-8
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(S)-GNE-987 (compound 4), the GNE-987 (a chimeric BET degrader) hydroxy-proline epimer, abrogates binding to von Hippel-Lindau and does not degrade BRD4 protein. (S)-GNE-987 can be used to design PROTAC-Antibody Conjugate (PAC) .
Referencia número: HY-P0221A
Synonyms: Pituitary Adenylate Cyclase Activating Polypeptide 38 TFA
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Referencia número: HY-P3483A
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Referencia número: HY-P1817A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
