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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
PAFR
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "PAFR" in MCE Product Catalog:
43
43 Publications Verification
Synonyms: PAF (C16)
Category:
Human Gut Microbiota Metabolites Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
3
Research Areas:
Apafant (WEB 2086), a chemical probe, is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a Ki of 9.9 nM. Apafant increases the gene expression of PAF-r, α-globin, β-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit .
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Rilapladib (SB 659032) is a selective Lp-PLA2 (lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 230 pM . Rilapladib (SB 659032) is also a PAFR (Platelet Activating Factor Receptor) antagonist .
Research Areas:
C18-PAF, octadecane PAF, is the ligand of platelet-activating factor and PAF G protein-coupled receptor (PAFR). C18-PAF has renovasodilator properties and antihypertensive lipid properties. C18-PAF increases renal blood flow and causes dose-dependent systemic hypotension .
Cat. No.: HY-W700638A
CAS No.: 76166-55-7
Synonyms: AH 21-132
Research Areas:
Benafentrine maleate is a platelet activating factor receptor (PAFR) antagonist and a PDE 4 inhibitor .
Cat. No.: HY-177598
CAS No.: 123852-99-3
Research Areas:
F-0401 is a calcium antagonist with platelet-activating factor receptor (PAFR) antagonistic action. F-0401 can be used for the research of neurological disease, such as stroke .
Cat. No.: HY-106899
CAS No.: 135947-75-0
Research Areas:
MK 287 is a potent, selective and orally active antagonist of platelet-activating factor receptor (PAFR). MK 287 can inhibit [3H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with K1 values of 6.1, 3.2, and 5.49 nM, respectively. MK 287 can inhibit PAF-induced aggregation of platelets in plasma or gel-filtered platelets and elastase release from PMNs with ED50 values of 56, 1.5 and 4.4 nM. MK 287 can be used for the research of cardiovascular disease, such as thrombosis .
Cat. No.: HY-N11932
CAS No.: 164268-04-6
Cat. No.: HY-132210
CAS No.: 116673-45-1
Research Areas:
rel-(2R,4R)-2,4-Bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane (compound 6) is a platelet-activating factor receptor (PAFR) antagonist with a Ki of 0.3 µM .
Cat. No.: HY-108635R
CAS No.: 74389-68-7
Synonyms: PAF (C16) (Standard)
Cat. No.: HY-RS11349
Target:
Research Areas:
Ptafr Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptafr gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS11347
Target:
Research Areas:
PTAFR Human Pre-designed siRNA Set A contains three designed siRNAs for PTAFR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS11348
Target:
Research Areas:
Ptafr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptafr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-121394
CAS No.: 113787-28-3
Research Areas:
L-659,989 is an orally active, extremely potent, selective and competitive platelet activating factor (PAF) receptor antagonist .
Cat. No.: HY-N3436
CAS No.: 99340-07-5
Cat. No.: HY-117636
CAS No.: 129314-27-8
Research Areas:
(Rac)-L-659989 is the racemate of L-659989 (HY-121394). L-659989 s an orally active, extremely potent, selective and competitive platelet activating factor (PAF) receptor antagonist .
Synonyms: UK-74505
Target:
Research Areas:
(Rac)-Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. (Rac)-Modipafant prevents dengue infection .
Cat. No.: HY-134101
CAS No.: 78858-42-1
Research Areas:
2-O-Ethyl PAF C-16 is a homolog of PAF and a competitive ligand for PAF receptor (Platelet-activating Factor Receptor (PAFR)). 2-O-Ethyl PAF C-16 inhibits the binding of the PAF antagonist WEB 2086 (HY-108634) to the PAF receptor with an IC50 of 21 nM .
Cat. No.: HY-108634S
CAS No.: 1185101-22-7
Synonyms: WEB 2086-d8
Cat. No.: HY-132190
CAS No.: 137566-83-7
Synonyms: 1-O-Hexa-decyl-2-acetyl-sn-glycero-3-phospho(N,N,N-trimethyl)-hexanolamine
Research Areas:
Hexanolamino PAF C-16 (1-O-hexadecyl-2-acetyl-sn-glycero-3-phospho (N,N,N trimethyl) hexanolamine) is a Platelet-activating Factor Receptor (PAFR) Modulator with partial agonist activity. Hexanolamino PAF C-16 induces platelet aggregation and macrophage production but fails to increase [Ca2+]i in platelets, suggesting that PAF receptors may interact with PAF receptors through Ca 2+-dependent and -independent pathways. Related to platelet aggregation .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
