84 Results for "

PEP

" in MedChemExpress (MCE) Product Catalog:
Products (84)

84 Results for "PEP" in MCE Product Catalog:

5
5 Cited Publications
Cat. No.: HY-B0719
CAS No.: 75567-37-2
Synonyms: Ingenol 3-angelate; PEP005
Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.
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3
3 Cited Publications
Cat. No.: HY-162289
CAS No.: 3036029-78-1
Target:  

DNA/RNA Synthesis

Research Areas:  

Neurological Disease Cancer

FAZ-3780 is an inhibitor that binds to the NTF2L domain of G3BP1/2. FAZ-3780 binds to the NTF2L nsP3 of G3BP1 with high affinity, with a Kd of 0.15 μM and a Pep-FRET IC50 of 0.7 μM. FAZ-3780 targets the protein-protein interaction domain of G3BP1/2, and specifically inhibits the co-condensation of G3BP1, caprin 1 and RNA in vitro. FAZ-3780 inhibits stress granule formation and disassembles pre-formed stress granules. FAZ-3780 can be used in studies related to cancer and neurodegenerative diseases .
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2
2 Cited Publications
Cat. No.: HY-P1848
CAS No.: 395069-86-0
Target:  

Interleukin Related

Research Areas:  

Cancer

Pep-1 (uncapped) is a specific ligand of IL-13Ra2. Pep-1 (uncapped) exerts cell penetrating activity through receptor-mediated endocytosis, can cross the blood-tumor barrier (BTB) and target glioma cells. Pep-1 (uncapped) can enhance the uptake of nanoparticles by tumor cells and enhance the cell penetration ability of nanoparticles, and can be used to develop targeted drug delivery systems for glioma .
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1
1 Cited Publications
Cat. No.: HY-P3496
CAS No.: 1322711-38-5
Target:  

Pyroptosis

Research Areas:  

Inflammation/Immunology

Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis .
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1
1 Cited Publications
Cat. No.: HY-P4490
CAS No.: 95632-46-5
Research Areas:  

Others

Suc-Ala-Pro-pNA is a peptide that serves as a substrate to detect the activity and stability of prolyl endopeptidase (PEP) .
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1
1 Cited Publications
Cat. No.: HY-15114
CAS No.: 176797-26-5
Purity:  99.78%
Synonyms: S 17092-1
S 17092 (S 17092-1) is an orally active cerebral prolyl-endopeptidase (PEP) inhibitor with an IC50 of 1.2 nM. S 17092 inhibits cell apoptosis. S 17092 mechanism of action is to inhibit the activity of PEP, slowing down the degradation of neuroactive peptides and thus enhancing memory function. S 17092 can be used for the research of memory impairment and cognitive disorders associated with cerebral aging .
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1
1 Cited Publications
Cat. No.: HY-P99792
CAS No.: 2449086-91-1
Synonyms: NM57; rhRIG

Target:  

RABV

Research Areas:  

Infection

Ormutivimab (rhRIG) is a recombinant human monoclonal antibody, targeting rabies virus. Ormutivimab neutralizes a variety of rabies virus strains. Ormutivimab exhibits potent potency against rabies post-exposure prophylaxis (PEP) model .
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Cat. No.: HY-P2276
CAS No.: 1541011-97-5
Target:  

PCSK9

Research Areas:  

Cancer

Pep2-8 is a PCSK9 inhibitor with a binding KD of 0.7 μM and an IC50 of 1.4 μM .
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Cat. No.: HY-W712327
CAS No.: 105931-44-0
Research Areas:  

Others

D-Xylulose 5-phosphate sodium is a pentose phosphate ester and an essential intermediate metabolite in the pentose phosphate pathway (PPP) and the non-oxidative phase of the pentose phosphate pathway. D-xylulose-5-phosphate sodium can be efficiently synthesized through the phosphorylation of D-xylulose catalyzed by D-xylulokinase (XKS1 from Saccharomyces cerevisiae), with ATP regeneration facilitated by the phosphoenolpyruvate (PEP)/pyruvate kinase (PK) system .
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Cat. No.: HY-113167
CAS No.: 2553-59-5
Synonyms: DL-2-phosphoglyceric acid
2-Phosphoglyceric acid (DL-2-phosphoglyceric acid) is a glycolytic substrate that is catalyzed by enolase to form phosphoenolpyruvate ester (PEP). 2-Phosphoglyceric acid inhibits the ferroptosis pathway by down-regulating ACSL4 and up-regulating GPX4, and has significant neuroprotective effects. 2-Phosphoglyceric acid reflects the overall metabolic state and flux of the cell .
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Cat. No.: HY-P5366
Target:  

Liposome

Research Areas:  

Others

PEP1 is an amphipathic α-helical peptide containing 31 residues. The interaction of PEP1 with POPC-supported lipid bilayers (SLBs) is concentration-dependent: at low concentrations, it inserts into SLBs to generate compressive stress; at medium concentrations, it saturates the membrane surface to maintain constant stress; and at high concentrations, it solubilizes SLBs. PEP1 can be used for research on the mechanism of membrane-peptide interactions .
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Cat. No.: HY-P11287A
DOTA-Pep-1L TFA is a polypeptide formed by the conjugation of DOTA and Pep-1L. DOTA-Pep-1L TFA specifically binds to IL13RA2 and can be used for the synthesis of targeted polypeptides. DOTA-Pep-1L TFA yields the isotopically labeled product [ 225Ac]DOTA-Pep-1L, which exerts α-radiation killing effects on orthotopic glioma cells and extends the median survival time of mice bearing orthotopic glioma models after stereotactic injection. DOTA-Pep-1L TFA can be used for PET imaging, tumor targeting and glioma research .
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Cat. No.: HY-113951
CAS No.: 86925-97-5
Purity:  98.34%
Synonyms: Boc-Pro-prolinal; (Boc)-Prolyl-prolinal
Research Areas:  

Neurological Disease

Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) is a potent prolyl endopeptidase (PEP; PE) inhibitor, with a Ki value of 15 nM. Prolyl Endopeptidase Inhibitor 1 has anti-amnesic effect .
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Cat. No.: HY-137220
CAS No.: 65022-15-3
Purity:  99.38%
Research Areas:  

Others

Z-Gly-Pro-pNA is a substrate for measuring prolyl endopeptidase (PEP) inhibitory activity .
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Cat. No.: HY-P10292
NOTA-Pep-1L specifically targets the IL13RA2 receptor for tumor imaging . NOTA-Pep-1L can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
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Cat. No.: HY-19123
CAS No.: 130849-58-0
Research Areas:  

Neurological Disease

Z-321 is a prolylendopeptidase (PEP) inhibitor.
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Cat. No.: HY-P4119
CAS No.: 863608-35-9
Research Areas:  

Others

Pep-1-Cysteamine is an amphipathic chimeric cell-penetrating peptide. Pep-1-Cysteamine can penetrate biological membranes in an energy-independent manner without forming transmembrane pores, and efficiently deliver active proteins into cells, with its translocation dominated by electrostatic interactions and membrane perturbation .
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Cat. No.: HY-P10374
CAS No.: 900518-62-9
Target:  

Peptides

Research Areas:  

Cancer

Pep42, a cyclic peptide ligand of GPR78, internalizes selectively into highly metastatic human melanoma cells through a receptor-mediated process .
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Cat. No.: HY-P11097
CAS No.: 3056822-31-9
Target:  

CD47

Research Areas:  

Cancer

Pep-20 is a CD47/SIRPα blocking peptide with KD values of 2.91 and 3.63 μM for human and mouse CD47, respectively. IC50 values for blocking the human and mouse CD47/SIRPα interaction are 24.56 and 12.03 μM, respectively. Pep-20 has antitumor activity .
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Cat. No.: HY-P11287
DOTA-Pep-1L is a polypeptide formed by the conjugation of DOTA and Pep-1L. DOTA-Pep-1L specifically binds to IL13RA2 and can be used for the synthesis of targeted polypeptides. DOTA-Pep-1L yields the isotopically labeled product [ 225Ac]DOTA-Pep-1L, which exerts α-radiation killing effects on orthotopic glioma cells and extends the median survival time of mice bearing orthotopic glioma models after stereotactic injection. DOTA-Pep-1L can be used for PET imaging, tumor targeting and glioma research .
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