Pep-1 (uncapped)
Based on 2 publication(s) in Google Scholar
Pep-1 (uncapped) is a specific ligand of IL-13Ra2. Pep-1 (uncapped) exerts cell penetrating activity through receptor-mediated endocytosis, can cross the blood-tumor barrier (BTB) and target glioma cells. Pep-1 (uncapped) can enhance the uptake of nanoparticles by tumor cells and enhance the cell penetration ability of nanoparticles, and can be used to develop targeted drug delivery systems for glioma.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 395069-86-0
- Formula: C136H195N35O33
- Molecular Weight:2848.22
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Pep-1 (uncapped)
More
Biological Activity
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IL-13 |
Pep-1 (uncapped) enters the hydrophobic region of biological membranes and interacts more strongly with the phosphate groups of normal cell membrane vesicles and the carbonyl groups of cancer cell membrane vesicles[1].
Pep-1 (uncapped) (200 μg/mL; 4 h) enhances nanoparticle uptake through IL-13Ra2-mediated endocytosis in C6 glioma cells, and the cell fluorescence intensity is 1.55 times higher than that of unmodified nanoparticles[2].
Pep-1 (uncapped) (400 μg/mL; 4 h) enables nanoparticle penetration depth of 120 μm in C6 glioma 3D spheroids[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 395069-86-0
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Appearance Solid
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Molecular Weight 2848.22
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Formula C136H195N35O33
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Color White to off-white
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Sequence
Lys-Glu-Thr-Trp-Trp-Glu-Thr-Trp-Trp-Thr-Glu-Trp-Ser-Gln-Pro-Lys-Lys-Lys-Arg-Lys-Val
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Sequence Shortening
KETWWETWWTEWSQPKKKRKV
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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J Adv Res
Rational engineering of an antifreeze-based biomaterial with dual-enhanced ice-binding and delivery for high-efficiency cryopreservation. [Abstract]2025 Dec 8:S2090-1232(25)00998-1. PMID: 41371403 -
Membranes
2025 Dec 3;15(12):373. PMID: 41441076
Solvent & Solubility
H2O : 100 mg/mL (35.11 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Almarwani B, et al. Vesicles mimicking normal and cancer cell membranes exhibit differential responses to the cell-penetrating peptide Pep-1. Biochim Biophys Acta Biomembr. 2018 Jun;1860(6):1394-1402. [Content Brief]
[2]. Wang B, et al. Nanoparticles functionalized with Pep-1 as potential glioma targeting delivery system via interleukin 13 receptor α2-mediated endocytosis. Biomaterials. 2014 Jul;35(22):5897-907. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.3511 mL | 1.7555 mL | 3.5110 mL | 8.7774 mL |
| 5 mM | 0.0702 mL | 0.3511 mL | 0.7022 mL | 1.7555 mL | |
| 10 mM | 0.0351 mL | 0.1755 mL | 0.3511 mL | 0.8777 mL | |
| 15 mM | 0.0234 mL | 0.1170 mL | 0.2341 mL | 0.5852 mL | |
| 20 mM | 0.0176 mL | 0.0878 mL | 0.1755 mL | 0.4389 mL | |
| 25 mM | 0.0140 mL | 0.0702 mL | 0.1404 mL | 0.3511 mL | |
| 30 mM | 0.0117 mL | 0.0585 mL | 0.1170 mL | 0.2926 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Pep-1 (uncapped) Related Classifications
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