PVR-L2

By Targets:	Drug Derivative (1) Endogenous Metabolite (2) Isotope-Labeled Compounds (1) Nectin-4 (1) Small Interfering RNA (siRNA) (3) Thyroid Hormone Receptor (2)
By Research Areas:	Cancer (5) Endocrinology (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0070A

Liothyronine 35+ Cited Publications Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with K_is of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR .

HY-RS09175

NECTIN2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NECTIN2 Human Pre-designed siRNA Set A contains three designed siRNAs for NECTIN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NECTIN2 Human Pre-designed siRNA Set A NECTIN2 Human Pre-designed siRNA Set A

HY-RS18105

Nectin2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nectin2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nectin2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nectin2 Mouse Pre-designed siRNA Set A Nectin2 Mouse Pre-designed siRNA Set A

HY-A0070AS5

Liothyronine-d4 Triiodothyronine-d₄; 3,3',5-Triiodo-L-thyronine-d₄; T3-d₄	Isotope-Labeled Compounds Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
Liothyronine-d₄ (Triiodothyronine-d₄) is the deuterium labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with vs of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR .

HY-P992428

NTX-1107C	Nectin-4	Cancer
NST0036 is a human monoclonal antibody against *CD112/Nectin-2/PVRL2*. NST0036 can be used in cancer research.

HY-P992381

IBI352g4a	Drug Derivative	Cancer
IBI352g4a is a humanized IgG1 monoclonal antibody targeting PVRIG (K_d = 0.53 nM) and acts as a *PVRIG/PVRL2* inhibitor. The anti-tumor effect of IBI352g4a depends on the binding of its Fc region to FcγR. IBI352g4a binds to the extracellular domains of human and cynomolgus monkey PVRIG, and blocks the PVRIG-PVRL2 interaction. IBI352g4a induces NK cell activation, promotes their degranulation and tumor killing. IBI352g4a can be used in the research of gastric cancer .

HY-RS24579

Nectin2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nectin2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nectin2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nectin2 Rat Pre-designed siRNA Set A Nectin2 Rat Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area	Image

HY-P99763

Ociperlimab BGB-A1217	Inhibitory Antibodies	Cancer
Ociperlimab is a humanized IgG1 anti-TIGIT antibody. Ociperlimab binds to the extracellular domain of human TIGIT with high affinity (K_D = 0.135 nM). Ociperlimab blocks the interaction between TIGIT and its ligands PVR or PVR-L2. Ociperlimab can be used in research of cancer ^[2].

HY-P992428

NTX-1107C	Nectin-4	Cancer
NST0036 is a human monoclonal antibody against *CD112/Nectin-2/PVRL2*. NST0036 can be used in cancer research.

HY-P992381

IBI352g4a	Drug Derivative	Cancer
IBI352g4a is a humanized IgG1 monoclonal antibody targeting PVRIG (K_d = 0.53 nM) and acts as a *PVRIG/PVRL2* inhibitor. The anti-tumor effect of IBI352g4a depends on the binding of its Fc region to FcγR. IBI352g4a binds to the extracellular domains of human and cynomolgus monkey PVRIG, and blocks the PVRIG-PVRL2 interaction. IBI352g4a induces NK cell activation, promotes their degranulation and tumor killing. IBI352g4a can be used in the research of gastric cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0070A

Liothyronine 35+ Cited Publications Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Endocrinology	Thyroid Hormone Receptor Endogenous Metabolite
Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with K_is of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR .

Species:	Human (8) Rhesus Macaque (1) Mouse (1) Rat (1)
Tag:	His (6) Tag Free (1) Avi (4) Fc (4)
Source:	HEK293 (11)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78920

	Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, mFc-Avi) CD112; Nectin-2; PVRL2	Human	HEK293
	Nectin-2/CD112 protein has dual roles in T-cell signaling: as a costimulator with CD226, promoting proliferation and cytokine production, and as a coinhibitor with PVRIG, inhibiting proliferation. It also acts as a cell adhesion protein and a receptor for certain viruses. Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, mFc-Avi) is the recombinant human-derived Nectin-2/CD112 protein, expressed by HEK293 , with C-Avi, C-mFc labeled tag. The total length of Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, mFc-Avi) is 329 a.a., with molecular weight of 70-90 kDa.

HY-P74735

	Nectin-2 Protein, Rat (HEK293, His) Nectin cell adhesion molecule 2; Poliovirus receptor-related 2; PVRL2	Rat	HEK293
	Nectin-2/CD112 Protein, functioning as a laminin alpha-5 receptor, displays potential involvement in intracellular signaling, reflecting its similarity to related proteins. Nectin-2/CD112 Protein, Rat (HEK293, His) is the recombinant rat-derived Nectin-2/CD112 protein, expressed by HEK293 , with C-His labeled tag.

HY-P704309

	Nectin-2/CD112 Protein, Human (HEK293, mFc) Nectin-2; CD112; NECTIN2; PVRL2; HVEB; PRR2	Human	HEK293
	Nectin-2/CD112 protein has dual roles in T-cell signaling: as a costimulator with CD226, promoting proliferation and cytokine production, and as a coinhibitor with PVRIG, inhibiting proliferation. It also acts as a cell adhesion protein and a receptor for certain viruses. Nectin-2/CD112 Protein, Human (HEK293, mFc) is the recombinant human-derived Nectin-2/CD112 protein, expressed by HEK293, with C-mFc labeled tag.

HY-P73307

	Nectin-2/CD112 Protein, Human (HEK293) Nectin-2; CD112; NECTIN2; PVRL2; HVEB; PRR2	Human	HEK293
	Nectin-2/CD112 protein has dual roles in T-cell signaling: as a costimulator with CD226, promoting proliferation and cytokine production, and as a coinhibitor with PVRIG, inhibiting proliferation. It also acts as a cell adhesion protein and a receptor for certain viruses. Nectin-2/CD112 Protein, Human (HEK293) is the recombinant human-derived Nectin-2/CD112 protein, expressed by HEK293 , with tag free.

HY-P76507

	Nectin-2/CD112 Protein, Rhesus Macaque (HEK293, His) Nectin-2; CD112; NECTIN2; PVRL2; HVEB; PRR2	Rhesus Macaque	HEK293
	Nectin-2, a poliovirus receptor-related 2 protein, is a type I transmembrane glycoprotein and a member of the Ig gene superfamily. Nectin-2, also known as CD112, is an adhesion molecule involved in the formation of cell junctions and interactions with other Nectin-family molecules. Nectin-2/CD112 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived Nectin-2/CD112 protein, expressed by HEK293 , with C-His labeled tag.

HY-P78495

	Nectin-2/CD112 Protein, Human (HEK293, His-Avi) CD112; MPH; Nectin2; PRR2; PVRL2; HVEB; PVRR2	Human	HEK293
	Nectin-2/CD112 protein has dual roles in T-cell signaling: as a costimulator with CD226, promoting proliferation and cytokine production, and as a coinhibitor with PVRIG, inhibiting proliferation. It also acts as a cell adhesion protein and a receptor for certain viruses. Nectin-2/CD112 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Nectin-2/CD112 protein, expressed by HEK293 , with C-His, C-Avi labeled tag.

HY-P78372

	Nectin-2/CD112 Protein, Human (HEK293, Fc) CD112; MPH; Nectin2; PRR2; PVRL2; HVEB; PVRR2	Human	HEK293
	Nectin-2/CD112 protein has dual roles in T-cell signaling: as a costimulator with CD226, promoting proliferation and cytokine production, and as a coinhibitor with PVRIG, inhibiting proliferation. It also acts as a cell adhesion protein and a receptor for certain viruses. Nectin-2/CD112 Protein, Human (HEK293, Fc) is the recombinant human-derived Nectin-2/CD112 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P705059

	Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, Fc-Avi) Poliovirus Receptor-Related Protein 2; Herpesvirus Entry Mediator B; HveB; CD112; PVRL2; HVEB; PRR2	Human	HEK293

HY-P72400

	Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, His-Avi) Poliovirus Receptor-Related Protein 2; Herpesvirus Entry Mediator B; HveB; CD112; PVRL2; HVEB; PRR2	Human	HEK293
	Nectin-2/CD112 protein has dual roles in T-cell signaling: as a costimulator with CD226, promoting proliferation and cytokine production, and as a coinhibitor with PVRIG, inhibiting proliferation. It also acts as a cell adhesion protein and a receptor for certain viruses. Nectin-2/CD112 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Nectin-2/CD112 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

HY-P7780

	Nectin-2/CD112 Protein, Human (HEK293, His) rHuCD112, His; Poliovirus Receptor-Related Protein 2; Herpes Virus Entry Mediator B; Herpesvirus Entry Mediator B; CD112; PVRL2; HVEB; PRR2	Human	HEK293
	CD112 Protein, Human (HEK293, His) is a recombinant human CD112 expressed in HEK 293 cells with a His tag at the N-terminus. Recombinant Human CD112 can be used as cell surface ligands for the human DNAM-1 (CD226) activating molecule.

HY-P7781

	Nectin-2/CD112 Protein, Mouse (HEK293, His) rMuCD112, His; Poliovirus Receptor-Related Protein 2; Herpes Virus Entry Mediator B; Herpesvirus Entry Mediator B; CD112; PVRL2; HVEB; PRR2	Mouse	HEK293
	Nectin-2/CD112 Protein, Mouse (HEK293, His) is a recombinant mouse CD112 expressed in HEK 293 cells with a His tag at the N-terminus. Nectin-2/CD112 Protein can be used as cell surface ligands for the DNAM-1 (CD226) activating molecule.

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Cat. No.	Product Name	Chemical Structure

HY-A0070AS5

Liothyronine-d4
Liothyronine-d₄ (Triiodothyronine-d₄) is the deuterium labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with vs of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR .

Host:	Rabbit (2)
Reactivity:	Human (2)
Application:	IHC-P (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2) Biotin (3)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81451

	Nectin 2 Antibody (YA1196) NECTIN2; HVEB, PRR2, PVRL2; CD112; Nectin-2; Herpes virus entry mediator B (Herpesvirus entry mediator B; HveB); Nectin cell adhesion molecule 2; Poliovirus receptor-related protein 2	IHC-P	Human
	Nectin 2 Antibody (YA1196) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nectin 2.

HY-P81451A

	Nectin 2 Antibody (YA1196)(PBS only) NECTIN2; HVEB, PRR2, PVRL2; CD112; Nectin-2; Herpes virus entry mediator B (Herpesvirus entry mediator B; HveB); Nectin cell adhesion molecule 2; Poliovirus receptor-related protein 2	IHC-P	Human
	Nectin 2 Antibody (YA1196) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nectin 2.

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Cat. No.	Product Name		Classification

HY-RS09175

NECTIN2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
NECTIN2 Human Pre-designed siRNA Set A contains three designed siRNAs for NECTIN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18105

Nectin2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Nectin2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nectin2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24579

Nectin2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Nectin2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nectin2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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