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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
Plasminogen activator inhibitor-1
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "Plasminogen activator inhibitor-1" in MCE Product Catalog:
17
17 Publications Verification
Synonyms: PAI-039; Tiplasinin
Research Areas:
Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 μM .
10
10 Cited Publications
Research Areas:
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 μM and induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence .
4
4 Cited Publications
Cat. No.: HY-N1504
CAS No.: 119425-90-0
Category:
Dracaena cochinchinensis (Lour.) S. C. Chen Flavonoids Monophenols Metabolic Disease Phenols Agavaceae Plants Dihydrochalcones Disease Research Fields
Target:
2
2 Cited Publications
Cat. No.: HY-P71077
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPINE1; Endothelial Plasminogen activator inhibitor; Prev. PLANH1; Serpin E1; Prev. PAI1; PAI-1; PAI; Serpin Peptidase inhibitor, Clade E (Nexin, Plasminogen activator inhibitor Type 1), Member 1; Serine (Or Cysteine) Proteinase inhibitor, Clade E (Nexi
Species:
Human
Source:
HEK293
1
Research Areas:
Drospirenone (Dihydrospirorenone) is an orally active fourth-generation progestin that interacts with the progesterone receptor (PR) and androgen receptor (AR). Drospirenone significantly decreases both plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) via the AR. Drospirenone can produce DNA damage in bone marrow cells of female mice. .
1
Category:
Cardiovascular Disease Toddalia asiatica (L.) Lam. Rutaceae Coumarins Phenylpropanoids Plants Disease Research Fields
Target:
1
1 Cited Publications
Cat. No.: HY-P71133
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPINE1; Endothelial Plasminogen activator inhibitor; Prev. PLANH1; Serpin E1; Prev. PAI1; PAI-1; PAI; Serpin Peptidase inhibitor, Clade E (Nexin, Plasminogen activator inhibitor Type 1), Member 1; Serine (Or Cysteine) Proteinase inhibitor, Clade E (Nexin, Plasminogen activator inhibitor Type 1), Member 1; Plasminogen activator inhibitor, Type I; Serpin Family E Member 1; Plasminogen activator inhibitor 1
Species:
Mouse
Source:
HEK293
Synonyms: PAI-749
Target:
Research Areas:
Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 295 nM. Diaplasinin has antithrombotic efficacy .
Cat. No.: HY-165084
CAS No.: 383908-63-2
Synonyms: Soy PS sodium
Research Areas:
L-α-Phosphatidylserine sodium (Soy PS sodium) is a negatively charged phospholipid that acts as an allosteric activator to activate latent plasminogen activator inhibitor-1 (PAI-1). L-α-Phosphatidylserine does not directly alter the catalytic activity of t-PA, but regulates fibrinolytic activity solely by inducing conformational remodeling of PAI-1. L-α-Phosphatidylserine sodium is an antigen targeting phosphatidylserine (PS) and can induce the production of polyclonal antibodies. L-α-Phosphatidylserine is mainly used in studies related to immunology, fibrinolytic system and coagulation homeostasis .
Target:
Research Areas:
Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases .
Cat. No.: HY-106508
CAS No.: 53597-27-6
Synonyms: HP 129; P 71-0129
Target:
Research Areas:
Fendosal (HP 129) is an orally active, potent non-steroidal anti-inflammatory agent. Fendosal (HP 129) is also an inhibitor of Plasminogen activator inhibitor-1 (PAI-1) .
Category:
Human Gut Microbiota Metabolites Microorganisms Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-101761A
CAS No.: 2319722-53-5
Research Areas:
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 μM. TM5441 induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence .
Cat. No.: HY-187613
CAS No.: 158944-02-6
Target:
Research Areas:
XR 1853 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor. XR 1853 inhibits active PAI-1. XR 1853 can be used for the research of thrombotic diseases .
Target:
Cat. No.: HY-119160
CAS No.: 342595-05-5
Target:
Research Areas:
TM5007 is a poent and orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1) with an IC50 of 29 μM. TM5007 enhance fibrinolysis activity and inhibits coagulation. TM5007 also prevents the fibrotic process initiated by bleomycin in mouse lung .
Cat. No.: HY-N1504R
CAS No.: 119425-90-0
Category:
Dracaena cochinchinensis (Lour.) S. C. Chen Flavonoids Monophenols Phenols Agavaceae Plants Dihydrochalcones
Target:
Cat. No.: HY-187154
CAS No.: 20283-21-0
1-Decanesulfonic acid is an alkanesulfonate anionic surfactant that acts as a neutralizer of plasminogen activator inhibitor-1 (PAI-1). 1-Decanesulfonic acid binds to the hydrophobic region in the flexible linker domain of active PAI-1. 1-Decanesulfonic acid induces PAI-1 polymerization via a two-step neutralization mechanism .
Cat. No.: HY-P992313
Target:
Research Areas:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
