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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
SALL4
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "SALL4" in MCE Product Catalog:
1
1 Cited Publications
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NVP-DKY709 is an orally active and selective IKZF2 molecular glue degrader with the Dmax and DC50 of 53% and 4 nM, respectively. In addition, NVP-DKY709 can degrade IKZF4 (DC50: 13 nM) and SALL4 (DC50: 2 nM). NVP-DKY709 exerts anti-tumor activity by binding with CRBN to change conformation and recruit and degrade IKZF2 .
Cat. No.: HY-W599279
CAS No.: 2761170-84-5
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ABS-752 is a potent and orally active GSPT1 and NEK7 molecular glue degrader. ABS-752 shows cytotoxicity. ABS-752 decreases the protein expression of GSPT1 and SALL4, NEK7. ABS-752 is a prodrug activated by the monoamine oxidase, VAP-1, to an aldehyde intermediate and subsequently to the active molecule, ABT-002 (HY-175283). ABS-752 has the potential for the research of hepatocellular carcinoma .
Cat. No.: HY-RS12420
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SALL4 Human Pre-designed siRNA Set A contains three designed siRNAs for SALL4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS21750
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Sall4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sall4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-175875
CAS No.: 3090685-19-8
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HRZ-01-082-5 is an analog of Glutarimide (HY-I0466). HRZ-01-082-5 is a dual-functional molecular glue degrader of SALL4 and OSR1 with a DC50 4.8 nM for OSR1. HRZ-01-082-5 significantly induced SALL4 and OSR1 degradation through CRBN. HRZ-01-082-5 can be used for heart and urogenital development, as well as cancers research .
Cat. No.: HY-RS28268
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Sall4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sall4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W1128213
CAS No.: 2983841-00-3
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IKZF2-degrader 2 is a selective and orally active IKZF2 molecular glue degrader with DC50 values of 0.5 nM and 1.8 nM in HiBit and FACS. The IKZF2-degrader 2 mediates the ubiquitination and degradation of target proteins by recruiting the CRL4-CRBN E3 ubiquitin ligase. IKZF2-degrader 2 displays moderate degradation against SALL4 with a DC50 of 9 nM but does not induce any significant degradation towards IKZF1, IKZF3, CK1α and GSPT1. IKZF2-degrader 2 can be used for the study of cancer immunology .
Cat. No.: HY-169348
CAS No.: 259130-14-8
β-catenin-IN-8 (Compound 25) is a β-catenin inhibitor. β-catenin-IN-8 inhibits β-catenin and c-Myc protein levels, and inhibits Wnt-target genes level (Fgf20 and Sall4). β-catenin-IN-8 has colorectal cancer anticancer activities, and has metabolic stability .
Cat. No.: HY-P82154A
Synonyms: Zinc finger protein 797; Zinc finger protein SALL4
Cat. No.: HY-187338
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CRBN ligand-908 is a cereblon (CRBN) ligand and also a HaloTag-binding degrader. CRBN ligand-908 competes with fluorescent lenalidomide ligands for binding to full-length CRBN protein. CRBN ligand-908 contains a chlorohexyl group that covalently reacts with HaloTag fused to target proteins. CRBN ligand-908 induces degradation of HaloTag-fused FAK, endogenous MARC1, and BRD4 proteins. CRBN ligand-908 is a proteasome- and Cullin-dependent degrader. CRBN ligand-908 does not induce degradation of the novel CRBN substrates GSPT1, SALL4, or CSNK1α. CRBN ligand-908 can be used to synthesize PROTACs, such as HaloPROTAC 4 (HY-187337) .
Cat. No.: HY-P84867A
Synonyms: DRRS; HSAL4; ZNF797; dJ1112F19.1
Cat. No.: HY-L140
232 compounds
Withdrawal or delisting drugs refer to drugs that are recalled or discontinued from the market due to low efficiency, serious side effects, financial and regulatory problems and other reasons. Once the drug is withdrawn from the market, it will cause heavy losses to the original research company that invested a lot of time, finance and other costs to develop the drug.
Adverse drug reaction (ADR) is the main reason for drug withdrawal from the market. ADR refers to the unexpected effects caused by the reasons such as the target-directed interaction during the treatment. However, studying the mechanism of these ADRs may just be a breakthrough in finding new indications. For example, thalidomide, the protagonist of the drug damage event that caused numerous "seal babies" deformed infants, was found to be due to the degradation of a transcription factor - SALL4 after delisting, which made thalidomide have a new clinical application. In 1998, it was approved by FDA for the treatment of leprosy nodular erythema, and in 2006, it was approved for the treatment of multiple myeloma. ADR study of delisted drugs can not only avoid the loss of drug development in advance but also bring hope to new indications.
MCE has sorted out 232 drug compounds withdrawn from the market through FDA, EMA and other authoritative platforms. Each compound has withdrawal records in at least one country/market. It is a useful tool for conducting research on drug side effects or drug toxicity mechanisms and discovering new indications of drugs.
Cat. No.: HY-187337
HaloPROTAC 4 is a HaloPROTAC degrader with a pIC50 of 8.1 against human CRBN. HaloPROTAC 4 binds to CRBN to recruit the CUL4CRBN E3 ubiquitin ligase complex, and covalently binds to HaloTag fusion proteins, thereby inducing proteasome-dependent degradation of HaloTag fusion proteins. HaloPROTAC 4 serves as a protein knockdown tool for chemogenetic-related studies .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
