1 Result for "

SC428

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "SC428" in MCE Product Catalog:

Cat. No.: HY-164373
CAS No.: 1898232-70-6
Research Areas:  

Cancer

SC428 is an androgen receptor (AR) inhibitor that targets the N-terminal domain. SC428 potently decrease the transactivation of (AR)-V7, (AR)v567es, as well as full-length ( AR ) (AR-FL) and its LBD mutants, substantially. SC428 inhibits androgen-stimulated (AR)-FL nuclear translocation, chromatin binding, and (AR) -regulated gene transcription. SC428 inhibits the proliferation of tumor cells in vitro. SC428 inhibits tumor cell growth by inducing apoptosis in mice transplanted with 22RV1 .
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