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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
34 Results for "
SCG
" in MedChemExpress (MCE) Product Catalog:
Products (34)
34 Results for "SCG" in MCE Product Catalog:
Cat. No.: HY-P99899
CAS No.: 2052591-32-7
Synonyms: PR-1498487
Target:
Research Areas:
Samrotamab (PR-1498487) is a humanized IgG1-κ chimeric monoclonal antibody targeting LRRC15, with a Kd of 5.42 nM for human LRRC15. Samrotamab can be used to synthesize antibody-drug conjugates (ADC). Samrotamab disrupts the LRRC15-SCG5 signaling module, binds to a membrane-proximal conformational epitope within the C-terminal leucine-rich repeat region of LRRC15, and binds to the lateral edge of the LRR solenoid while leaving the canonical concave β-sheet surface fully exposed. Samrotamab reduces the viability of bladder cancer cells, inhibits clonogenic growth, impairs cell migration, and compromises cell invasion. Samrotamab induces compensatory upregulation of LRRC15 transcripts while suppressing the expression of SCG5 mRNA. Samrotamab is applicable to research related to urothelial carcinoma, sarcoma, osteosarcoma, and undifferentiated pleomorphic sarcoma .
Cat. No.: HY-RS12503
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SCG5 Human Pre-designed siRNA Set A contains three designed siRNAs for SCG5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS12501
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SCG2 Human Pre-designed siRNA Set A contains three designed siRNAs for SCG2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS12502
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SCG3 Human Pre-designed siRNA Set A contains three designed siRNAs for SCG3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19380
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Scg2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Scg2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS22319
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Scg5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Scg5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25649
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Scg3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Scg3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS28841
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Scg5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Scg5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-113985
CAS No.: 59939-16-1
Synonyms: LD 3098
Research Areas:
Cirazoline (LD 3098) is a doul agonist of Presynaptic imidazoline receptors (R(i-pre)) and α-adrenoceptor (R(α)). Cirazoline (30 μM) suppresses M current in SCG neurons cultured overnight .
Cat. No.: HY-RS19160
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Scg3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Scg3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25872
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Scg2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Scg2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-184689
CAS No.: 1311892-52-0
ORS-14 is a LILRB4/ILT3 ligand with a Kd of 85.2 nM for human receptors. ORS-14 blocks SCG2-mediated LILRB4 signaling pathway, reverses SCG2-mediated immunosuppression, restores cytokine production, reduces tumor cell viability, recovers cytotoxic T cell function, and increases the frequency of granzyme B + CD8 + T cells. ORS-14 can be used in research related to colorectal cancer and acute myeloid leukemia .
Cat. No.: HY-189933
CAS No.: 920836-30-2
Target:
Human leukocyte immunoglobulin (Ig)-like receptors (LILR) SHP1 SHP2 STAT IFNAR Interleukin Related
Research Areas:
ICB-7 is an orally active ILT3/LILRB4 inhibitor with a Kd of 156 nM for hILT3 and a Kd of 262 nM for mouse ILT3. ICB-7 reduces SCG2-induced phosphorylation of SHP1, SHP2, and STAT3. In a co-culture model, ICB-7 restores IFN-γ and IL-2 secretion and decreases cell viability under SCG2 stimulation. In a syngeneic cancer model, ICB-7 inhibits tumor progression and reduces final tumor weight. ICB-7 can be used for research on colorectal cancer and acute myeloid leukemia .
Cat. No.: HY-P88137A
Synonyms: Chgc; SCG-2; Secretogranin-2; Chromogranin-C; Secretogranin II; SgII
Cat. No.: HY-P700824
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SCG3; Secretogranin-3; Secretogranin III; FLJ90833; SgIII
Species:
Cynomolgus
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
