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Results for "

SIGLEC10

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Peptides

6

Inhibitory Antibodies

13

Recombinant Proteins

2

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P991480
    ONC-841

    		Transmembrane Glycoprotein Tau Protein Amyloid-β Neurological Disease Cancer
    ONC-841 is a blood-brain barrier-permeable, humanized monoclonal antibody targeting SIGLEC10. As an immune checkpoint inhibitor, ONC-841 restores the functions of immune effector cells such as T cells and enhances anti-tumor immune responses by blocking inhibitory signals mediated by SIGLEC10. ONC-841 restores the phagocytic and migratory activities of microglia, and promotes the phagocytosis of Amyloid-β and Tau protein aggregates by microglia. ONC-841 is applicable to research related to solid tumors and Alzheimer's disease .
    ONC-841
  • HY-P10091
    CD24/Siglec-10 blocking peptide, CSBP

    		PD-1/PD-L1 Cancer
    CD24/Siglec-10 blocking peptide, CSBP can not only block the interaction of CD24/Siglec-10 but also PD-1/PD-L1. CD24/Siglec-10 blocking peptide, CSBP can induce the phagocytosis of tumor cell .
    CD24/Siglec-10 blocking peptide, CSBP
  • HY-P99928
    Efprezimod alfa

    MK 7110; CD24 Fc

    		 Transmembrane Glycoprotein Cancer
    Efprezimod alfa (MK 7110; CD24 Fc) is a humanized CD24-Fc fusion protein. Efprezimod alfa enhances the interaction between CD24 and Siglec-10, thereby regulating the response of innate immune cells to damage-associated molecular patterns, inhibiting the activation of antigen-presenting cells and subsequent inflammatory responses. Efprezimod alfa is applicable to the research of acute graft-versus-host disease and acquired immunodeficiency syndrome .
    Efprezimod alfa
  • HY-RS12898
    SIGLEC10 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SIGLEC10 Human Pre-designed siRNA Set A contains three designed siRNAs for SIGLEC10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SIGLEC10 Human Pre-designed siRNA Set A
    SIGLEC10 Human Pre-designed siRNA Set A
  • HY-RS26351
    Siglec10 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Siglec10 Rat Pre-designed siRNA Set A contains three designed siRNAs for Siglec10 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Siglec10 Rat Pre-designed siRNA Set A
    Siglec10 Rat Pre-designed siRNA Set A
  • HY-P992303
    Anti-Siglec-10/CD24 Antibody

    		Transmembrane Glycoprotein Inflammation/Immunology
    Anti-Siglec-10/CD24 Antibody is a monoclonal antibody targeting Siglec-10. It can be used in ELISA, FACS, and functional assays. Isotype controls for Anti-Siglec-10/CD24 Antibody can be found in Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-Siglec-10/CD24 Antibody
  • HY-P992441
    PHST001

    		Transmembrane Glycoprotein Cancer
    PHST001 is a humanized anti-CD24 antibody. PHST001 binds cell-surface CD24, blocks CD24-Siglec10 interaction, and engages Fc receptors to promote macrophage-mediated tumor cell phagocytosis. PHST001 inhibits growth of breast cancer and ovarian cancer, and reduces metastatic lesions in mouse xenograft models. PHST001 can be used for the research of triple negative breast cancer, HER2+ breast cancer, metastatic tumors, and ovarian cancer .
    PHST001
  • HY-P992386
    IMM47

    		CD22 Cancer
    IMM47 is a humanized monoclonal antibody targeting CD24, which acts as a competitive inhibitor of the CD24/Siglec-10 interaction and exhibits potent anti-tumor activity. The EC50 value of IMM47 for CD24 is 0.289 nM, and its Ka is 0.876 nM. IMM47 selectively binds to CD24-positive tumor cells and human granulocytes. By competitively blocking CD24/Siglec-10 binding, IMM47 abrogates the immunosuppressive signals of tumor cells, clears tumor cells through multiple effector pathways including ADCC, ADCP, ADCT and CDC, upregulates the levels of M1 and M2 macrophages in the spleen, promotes macrophage antigen presentation and induces tumor-specific memory immunity. IMM47 can be used in cancer-related research .
    IMM47

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