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Results for "

STT3A

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-117383
    NGI-1
    15+ Cited Publications

    ML414

    		 Virus Protease Cancer
    NGI-1 (ML414) is a potent oligosaccharyltransferase (OST) inhibitor, directly targeting and blocking the function of the OST catalytic subunits STT3A and STT3B . NGI-1 is a cell permeable inhibitor and can effectively reduce virus infectivity without affecting cell viability .
    NGI-1
  • HY-175674
    NGI-235

    		NF-κB Toll-like Receptor (TLR) GLUT Inflammation/Immunology
    NGI-235 is an STT3A-selective oligosaccharyltransferase complex OST-A inhibitor. NGI-235 preferentially inhibits OST-A catalytic activity, impairing N-glycosylation of OST-A substrates. NGI-235 causes the hypoglycosylation of both TLR4, GLUT1 and inhibits NF-κB signaling. NGI-235 can be used for the research of inflammation .
    NGI-235
  • HY-169003
    STT3A/B-IN-1

    		Virus Protease Infection Neurological Disease Cancer
    STT3A/B-IN-1 is an orally active STT3A/B inhibitor with antiviral activity. STT3A/B-IN-1 upregulates DERL3 gene expression levels. STT3A/B-IN-1 is promising for research of viral diseases, including cancer and neurodegenerative disorders .
    STT3A/B-IN-1
  • HY-RS13970
    STT3A Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    STT3A Human Pre-designed siRNA Set A contains three designed siRNAs for STT3A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    STT3A Human Pre-designed siRNA Set A
    STT3A Human Pre-designed siRNA Set A
  • HY-176433
    NSC-323241

    		Flavivirus Infection
    NSC-323241 is a potent STT3A-mediated mega protein complex assembly inhibitor. NSC-323241 disrupts he endoplasmic reticulum (ER) mega complex nucleated by STT3A during dengue virus (DENV) and Zika virus (ZIKV) infection. NSC-323241 targets the binding of STT3A subcomplex with viral nonstructural proteins (e.g., NS2B, NS3) and host translocon proteins, disrupting the formation of viral replication microenvironment. NSC-323241 is promising for research of flavivirus infection, such as dengue fever and Zika virus .
    NSC-323241
  • HY-169003A
    (R,S)-STT3A/B-IN-1

    		Drug Isomer Virus Protease Infection Neurological Disease Cancer
    (R,S)-STT3A/B-IN-1 (compound 32), the racemate of STT3A/B-IN-1 (HY-16900), is a STT3A/B inhibitor. (R,S)-STT3A/B-IN-1 inhibits N-Glycosylation. (R,S)-STT3A/B-IN-1 is promising for research of viral diseases, including cancer and neurodegenerative disorders .
    (R,S)-STT3A/B-IN-1
  • HY-182914
    NGI-189

    		EGFR Akt Bcl-2 Family Apoptosis Cancer
    NGI‑189 is a selective OST‑A inhibitor. NGI‑189 inhibits the STT3A catalytic subunit of the OST complex and reduces N‑glycosylation of target glycoproteins. NGI‑189 blocks oncogenic and bypass signaling, reduces phosphorylation of EGFR, AKT, p70S6K and S6RP, and induces cell cycle arrest and apoptosis. NGI‑189 markedly suppresses tumor growth and induces tumor regression in non‑small cell lung cancer (NSCLC) xenograft models. NGI‑189 can be used for the research of EGFR‑mutant non‑small cell lung cancer .
    NGI-189

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