Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
SV2A
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "SV2A" in MCE Product Catalog:
2
Target:
Research Areas:
Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent [2].
1
Target:
Research Areas:
Seletracetam (Ucb 44212), as an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy [2] .
Cat. No.: HY-167830
CAS No.: 2242777-37-1
Research Areas:
SDM-8 is a difluoro-analog of UCB-J (HY-136873).SDM-8 shows high SV2A binding affinity with a Ki of 0.58 nM. SDM-8 can be used in the study of Alzheimer's disease .
Target:
Research Areas:
SDI-118 is an orally active modulator for synaptic vesicle glycoprotein 2A (SV2A) with an IC50 of 13 nM .
Cat. No.: HY-B0106R
CAS No.: 102767-28-2
Synonyms: UCB L059 (Standard)
Research Areas:
Levetiracetam (Standard) is the analytical standard of Levetiracetam. This product is intended for research and analytical applications. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent [2].
Cat. No.: HY-RS14054
Target:
Research Areas:
SV2A Human Pre-designed siRNA Set A contains three designed siRNAs for SV2A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS16880
Target:
Research Areas:
Sv2a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sv2a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Target:
Research Areas:
UCB-J is a ligand for synaptic vesicle protein 2A (SV2A) with pIC50 values for human and rat SV2A of 8.15 and 7.6 respectively. UCB-J can be used to display and quantify the total synaptic density throughout the brain [2] .
Cat. No.: HY-B0106S
CAS No.: 1133229-29-4
Synonyms: UCB L059-d6
Cat. No.: HY-RS23322
Target:
Research Areas:
Sv2a Rat Pre-designed siRNA Set A contains three designed siRNAs for Sv2a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-119810A
Synonyms: Ucb 44212 lithium
Target:
Research Areas:
Cat. No.: HY-119810B
CAS No.: 2024584-38-9
Synonyms: Ucb 44212 lithium bromide
Target:
Research Areas:
Seletracetam (Ucb 44212) lithium bromide, an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy [2] .
Cat. No.: HY-176866
CAS No.: 2222756-46-7
Target:
Research Areas:
Rodin-A is an orally active, brain-penetrant and selective histone deacetylase (HDAC)-co-repressor of repressor element-1 silencing transcription factor (CoREST) complex inhibitor with an IC50 value of 1.80 μM for the CoREST complex, 0.15 μM for HDAC1, and 0.43 μM for HDAC2. Rodin-A increases the acetylation level of histone H3K9, upregulates the expression of neuron-related genes, thereby promoting the increase in dendritic spine density, the colocalization of synaptic proteins (SV2A and PSD95), and the improvement of hippocampal long-term potentiation (LTP), exerting synaptic protection and repair activity. Rodin-A is promising for research of neurodegenerative diseases related to synaptic dysfunction, especially Alzheimer’s disease .
Cat. No.: HY-B0106S1
CAS No.: 1217851-16-5
Synonyms: UCB L059-d3
Cat. No.: HY-12772R
CAS No.: 112559-91-8
Synonyms: Itraconazole metabolite Hydroxy Itraconazole (Standard); R-63373 (Standard)
Target:
Research Areas:
Levetiracetam (Standard) is the analytical standard of Levetiracetam. This product is intended for research and analytical applications. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent [2].
Cat. No.: HY-176867
Target:
Research Areas:
Rodin-B is a selective histone deacetylase (HDAC)-co-repressor of repressor element-1 silencing transcription factor (CoREST) complex inhibitor with an IC50 value of 0.50 μM for the CoREST complex, 0.27 μM for HDAC1, and 0.28 μM for HDAC2. Rodin-B increases the acetylation level of histone H3K9, upregulates the expression of neuron-related genes, thereby promoting the increase in dendritic spine density, the colocalization of synaptic proteins (SV2A and PSD95), and the improvement of hippocampal long-term potentiation (LTP), exerting synaptic protection and repair activity. Rodin-B is promising for research of neurodegenerative diseases related to synaptic dysfunction, especially Alzheimer’s disease .
Cat. No.: HY-P87090
Synonyms: KIAA0736 antibody; OTTHUMP00000014065 antibody; SV2 antibody; SV2A antibody; SV2A_HUMAN antibody; Synaptic vesicle glycoprotein 2 antibody; Synaptic vesicle glycoprotein 2A antibody; Synaptic vesicle protein 2A antibody;
Cat. No.: HY-P87089
Synonyms: KIAA0736 antibody; OTTHUMP00000014065 antibody; SV2 antibody; SV2A antibody; SV2A_HUMAN antibody; Synaptic vesicle glycoprotein 2 antibody; Synaptic vesicle glycoprotein 2A antibody; Synaptic vesicle protein 2A antibody;
Cat. No.: HY-136873A
CAS No.: 1604786-87-9
Target:
Research Areas:
(Rac)-UCB-J (Compound 23) is a ligand for synaptic vesicle protein 2A (SV2A), with a pIC50 value of 8.2. (Rac)-UCB-J can be used as a PET tracer for SV2A to assist in the diagnosis of epilepsy research .
Cat. No.: HY-180554
CAS No.: 300587-89-7
Target:
Research Areas:
UCB1244283 is a synaptic vesicle glycoprotein 2A (SV2A) allosteric modulator. UCB1244283 binds to a secondary ligand-binding site in SV2A and enhances orthosteric ligand engagement when the orthosteric site is occupied, by stabilizing the occluded state and slowing ligand dissociation. UCB1244283 shows a clear protective effect against both tonic and clonic convulsions in sound-sensitive mice. UCB1244283 can be used for epilepsy research [2] .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
