11 Results for "

Sirolimus

" in MedChemExpress (MCE) Product Catalog:
Products (11)

11 Results for "Sirolimus" in MCE Product Catalog:

1441
Rapamycin
Rapamycin
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1441 Publications Verification
Cat. No.: HY-10219
CAS No.: 53123-88-9
Purity:  99.94%
Synonyms: Sirolimus; AY-22989; NSC 226080
Category:  

Microorganisms Macrolide Antibiotics Anti-inflammation/Immunoregulatory Anti-aging Antibiotics Disease Research Disease Research Fields Cancer

Target:  

mTOR FKBP Molecular Glues Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial

Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .
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Rapamycin-d3
Rapamycin-d3
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1 Cited Publications
Cat. No.: HY-10219S
CAS No.: 392711-19-2
Purity:  ≥93.0%
Synonyms: Sirolimus-d3; AY-22989-d3; NSC 226080-d3
Rapamycin-d3 (Sirolimus-d3; AY-22989-d3; NSC 226080-d3) is the deuterated-labeled Rapamycin (HY-10219). Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .
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Rapamycin (GMP)
Rapamycin (GMP)
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1 Cited Publications
Cat. No.: HY-10219G
CAS No.: 53123-88-9
Synonyms: Sirolimus (GMP); AY-22989 (GMP); NSC 226080 (GMP)
Rapamycin (Sirolimus) (GMP) is Rapamycin (HY-10219) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .
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Rapamycin (Standard)
Rapamycin (Standard)
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Cat. No.: HY-10219R
CAS No.: 53123-88-9
Synonyms: Sirolimus (Standard); AY-22989 (Standard); NSC 226080 (Standard)
Category:  

Microorganisms Macrolide Antibiotics Anti-inflammation/Immunoregulatory Antibiotics Disease Research Endogenous metabolite

Target:  

Reference Standards mTOR FKBP Molecular Glues Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial

Rapamycin (Standard) (Sirolimus (Standard)) is the analytical standard of Rapamycin (HY-10219). This product is intended for research and analytical applications. Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .
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Rapamycin (GMP Like)
Rapamycin (GMP Like)
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Cat. No.: HY-10219GL
CAS No.: 53123-88-9
Purity:  98.8%
Synonyms: Sirolimus (GMP Like); AY-22989 (GMP Like); NSC 226080 (GMP Like)
Rapamycin (Sirolimus) GMP Like is Rapamycin (HY-10219) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .
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Rapamycin-13C,d3
Rapamycin-13C,d3
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Cat. No.: HY-10219S1
Purity:  97.05%
Synonyms: Sirolimus-13C,d3; AY-22989-13C,d3 NSC 226080-13C,d3
Rapamycin- 13C,d3 (Sirolimus- 13C,d3) is the 13C, deuterated-labeled Rapamycin (HY-10219). Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .
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MPT0B392
MPT0B392
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Cat. No.: HY-101287
CAS No.: 1346169-92-3
Purity:  99.63%
Target:  

Microtubule/Tubulin JNK Apoptosis Caspase

Research Areas:  

Cancer

MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line .
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Sirolimus isomer C
Sirolimus isomer C
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Cat. No.: HY-W781875
CAS No.: 150821-39-9
Target:  

mTOR

Research Areas:  

Cancer

Sirolimus isomer C is an impurity of Rapamycin (Sirolimus) (HY-10219) .
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Rapamycin-13C,d3-1
Rapamycin-13C,d3-1
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Cat. No.: HY-W765245
Synonyms: Sirolimus-13C,d3-1; AY-22989-13C,d3-1
Rapamycin- 13C,d3-1 (Sirolimus- 13C,d3-1) is the deuterated, 13C-labeled Rapamycin (HY-10219). Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .
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Rapamycin-butyl ester
Rapamycin-butyl ester
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Cat. No.: HY-181873
Synonyms: Sirolimus-butyl ester
Target:  

Drug Derivative

Research Areas:  

Cancer

Rapamycin-butyl ester (Sirolimus-butyl ester) (Compound 9) is a derivative of Rapamycin (HY-10219). Rapamycin-butyl ester exhibits antiproliferative effects against liver cancer cells and renal cancer cells. Rapamycin-butyl ester can be used in research related to liver cancer and renal cancer .
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MPT0B392 (Standard)
MPT0B392 (Standard)
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Cat. No.: HY-101287R
CAS No.: 1346169-92-3
Target:  

Microtubule/Tubulin Reference Standards JNK Apoptosis Caspase

Research Areas:  

Cancer

MPT0B392 (Standard) is the analytical standard of MPT0B392 (HY-101287). This product is intended for research and analytical applications. MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line .
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