105 Results for "

Switzerland

" in MedChemExpress (MCE) Product Catalog:
Products (105)

105 Results for "Switzerland" in MCE Product Catalog:

6
Carmofur
Carmofur
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6 Publications Verification
Cat. No.: HY-B0182
CAS No.: 61422-45-5
Synonyms: HCFU
Target:  

Nucleoside Antimetabolite/Analog SARS-CoV Virus Protease FAAH Ceramidase Glutathione Peroxidase

Research Areas:  

Infection Inflammation/Immunology Cancer

Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC50 of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI) .
5
PKA Inhibitor Fragment (6-22) amide
PKA Inhibitor Fragment (6-22) amide
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5 Cited Publications
Cat. No.: HY-P1290
CAS No.: 121932-06-7
Synonyms: PKI-(6-22)-amide
Target:  

PKA

Research Areas:  

Neurological Disease

PKA Inhibitor Fragment (6-22) amide is a highly potent and specific competitive inhibitor of PKA, with Ki values of 1.7 nM and 1.6 nM against human and bovine PKA catalytic subunits, respectively. The IC50 of PKA Inhibitor Fragment (6-22) amide targeting bovine PKA is 8.6 nM. PKA Inhibitor Fragment (6-22) amide effectively abolishes PKA activity in mouse brain and spinal cord, and exerts in vivo efficacy via intracerebroventricular administration. PKA Inhibitor Fragment (6-22) amide significantly reverses low-dose morphine analgesic tolerance in mice and blocks photoaffinity labeling of cAMP-dependent protein kinase. PKA Inhibitor Fragment (6-22) amide can be applied to research in fields related to the mechanism of morphine analgesic tolerance and skin wound healing .
2
Anethole
Anethole
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2 Cited Publications
Cat. No.: HY-B0900
CAS No.: 104-46-1
Synonyms: Anise camphor; p-Propenylanisole; Isoestragole
Category:  

Leguminosae Simple Phenylpropanols Phenylpropanoids Plants Umbelliferae Vernonia Schreb. Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer

Target:  

Environmental Pollutants Apoptosis NF-κB Fungal Bacterial MMP

Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .
2
Temephos
Temephos
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2 Cited Publications
Cat. No.: HY-B1120
CAS No.: 3383-96-8
Synonyms: Temefos
Target:  

Insecticide Cholinesterase (ChE) Dengue Virus Flavivirus

Research Areas:  

Infection

Temephos (Temefos) is an orally active, blood-brain barrier-permeable organophosphate insecticide and AChE inhibitor. By irreversibly inhibiting AChE to induce cholinergic overactivation, Temephos effectively blocks larval development of Aedes aegypti (yellow fever mosquito) and Aedes albopictus (Asian tiger mosquito), and is commonly used in studies related to Dengue Virus, Zika Virus and other relevant pathogens. Temephos exhibits genotoxicity and neurodevelopmental toxicity, and may also cause liver injury, reproductive system abnormalities and cholinergic poisoning symptoms in mammals. Temephos tends to accumulate in adipose tissues and aquatic organisms, and is excreted via feces after metabolism through oxidation and hydrolysis. Note that CYP-mediated metabolic detoxification may reduce the actual larvicidal efficacy of Temephos against some mosquito species. Temephos can be used in research related to dengue fever, Zika virus disease, chikungunya and dracunculiasis .
1
Flunisolide
Flunisolide
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1 Cited Publications
Cat. No.: HY-B1121
CAS No.: 3385-03-3
Target:  

Glucocorticoid Receptor Apoptosis

Research Areas:  

Inflammation/Immunology Endocrinology

Flunisolide is a corticosteroid, which is an orally active glucocorticoid receptor activator with anti-inflammatory activity. Flunisolide can induce eosinophil apoptosis, and is used for the research of asthma or rhinitis, and inflammation .
1
Palonosetron hydrochloride
Palonosetron hydrochloride
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1 Cited Publications
Cat. No.: HY-A0021
CAS No.: 135729-62-3
Target:  

5-HT Receptor Flavivirus

Research Areas:  

Infection Cardiovascular Disease Neurological Disease

Palonosetron hydrochloride is a 5-HT3 antagonist primarily used to prevent acute, delayed, and overall chemotherapy-induced nausea and vomiting. In addition, Palonosetron hydrochloride exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells. Palonosetron hydrochloride also possesses antidepressant activity .
1
Deoxyartemisinin
Deoxyartemisinin
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1 Cited Publications
Cat. No.: HY-W013331
CAS No.: 72826-63-2
Synonyms: 2-Deoxyartemisinin
Target:  

TNF Receptor

Research Areas:  

Neurological Disease Inflammation/Immunology

Deoxyartemisinin (2-Deoxyartemisinin) is an orally active anti-inflammatory and analgesic agent. Deoxyartemisinin selectively reduces the level of the pro-inflammatory cytokine TNF-α. Deoxyartemisinin alleviates neuropathic pain, inflammatory pain, and croton oil-induced ear edema.\nDeoxyartemisinin exerts an analgesic effect against thermal stimulation. Deoxyartemisinin has anti-ulcer activity. Deoxyartemisinin can be used in research related to inflammatory diseases, pain, and gastric ulcers .
1
Neostigmine (methyl sulfate)
Neostigmine (methyl sulfate)
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1 Cited Publications
Cat. No.: HY-B1206
CAS No.: 51-60-5
Target:  

Cholinesterase (ChE)

Research Areas:  

Infection Neurological Disease

Neostigmine methyl sulfate is an AchE inhibitor. Neostigmine methyl sulfate increases endogenous acetylcholine levels, mediates antinociceptive effects, and alleviates heat-induced pain. Neostigmine methyl sulfate can be used in studies related to postoperative pain and sepsis .
1
N,N-Dimethylsphingosine
N,N-Dimethylsphingosine
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1 Cited Publications
Cat. No.: HY-108491
CAS No.: 119567-63-4
Purity:  99.4%
Target:  

SphK Apoptosis

Research Areas:  

Cancer

N,N-Dimethylsphingosine is a sphingosine kinase inhibitor. N,N-Dimethylsphingosine binds competitively to sphingosine kinase and blocks the conversion of sphingosine to sphingosine-1-phosphate. N,N-Dimethylsphingosine inhibits sphingosine-1-phosphate release and aggregation of platelets, and also exerts pro-apoptotic effects by resetting ceramide/sphingosine-1-phosphate homeostasis. N,N-Dimethylsphingosine can be used in cancer-related research .
1
HG-10-102-01
HG-10-102-01
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1 Cited Publications
Cat. No.: HY-13488
CAS No.: 1351758-81-0
Purity:  99.55%
Target:  

LRRK2 MNK

Research Areas:  

Neurological Disease

HG-10-102-01 is a highly potent, selective, and brain-penetrable LRRK2 inhibitor, with IC50 values of 20.3 and 3.2 nM against wild-type LRRK2 and LRRK2[G2019S], respectively. HG-10-102-01 also inhibits MNK2 and MLK1, with IC50 values of 0.6 and 2.1 μM. HG-10-102-01 can be used for Parkinson's disease (PD) research .
1
Terbuthylazine
Terbuthylazine
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1 Cited Publications
Cat. No.: HY-B1847
CAS No.: 5915-41-3
Target:  

Environmental Pollutants Acetolactate Synthase (ALS) Herbicide

Research Areas:  

Others

Terbuthylazine is an inhibitor of acetolactate syntase (ALS), is a selective herbicide. Terbuthylazine blocks electron transport in photosystem II via interaction with the D1-protein .
1
hFSH-β-(33-53) TFA
hFSH-β-(33-53) TFA
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1 Cited Publications
Cat. No.: HY-P3343A
Target:  

Estrogen Receptor/ERR

Research Areas:  

Endocrinology

hFSH-β-(33-53) TFA is a polypeptide corresponding to residues 33-53 of hFSH-β, and also a follicle-stimulating hormone (FSH) antagonist. hFSH-β-(33-53) stimulates basal estradiol synthesis in cells. hFSH-β-(33-53) TFA prolongs vaginal estrus in mice with normal estrous cycles .
1
Kisspeptin 13 TFA
Kisspeptin 13 TFA
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1 Cited Publications
Cat. No.: HY-P3641A
Target:  

GnRH Receptor

Research Areas:  

Neurological Disease Metabolic Disease

Kisspeptin 13 TFA is the TFA salt form of Kisspeptin 13 (HY-P3641). Kisspeptin-13 TFA inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 TFA activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 TFA interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 TFA is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research .
1
hFSH-β-(33-53)
hFSH-β-(33-53)
0 Images
1 Cited Publications
Cat. No.: HY-P3343
CAS No.: 142154-55-0
Target:  

Estrogen Receptor/ERR

Research Areas:  

Endocrinology

hFSH-β-(33-53) is a polypeptide corresponding to residues 33-53 of hFSH-β, and also a follicle-stimulating hormone (FSH) antagonist. hFSH-β-(33-53) stimulates basal estradiol synthesis in cells. hFSH-β-(33-53) prolongs vaginal estrus in mice with normal estrous cycles .
Trilaurin
Trilaurin
0 Images
Cat. No.: HY-126573
CAS No.: 538-24-9
Purity:  ≥98.0%
Category:  

Endogenous metabolite Disease Research Fields Lipid Cancer

Target:  

Endogenous Metabolite Biochemical Assay Reagents

Trilaurin is an orally active triglyceride. Trilaurin inhibits DMBA-induced, croton oil-promoted skin tumor formation in Swiss Webster mice. Trilaurin increases plasma high-density lipoprotein cholesterol and apolipoprotein A-I concentrations. Trilaurin is used as an occlusive skin conditioning agent and/or non-aqueous thickener in cosmetics .
α-Santalol
α-Santalol
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Cat. No.: HY-N11908
CAS No.: 115-71-9
Synonyms: cis-α-Santalol
Category:  

Santalum album Linn. Terpenoids Sesquiterpenes Plants Santalaceae

Target:  

Akt Survivin Apoptosis Caspase PARP

α-Santalol (cis-α-Santalol), a naturally occurring sesquiterpene, is an orally active anticancer agent and apoptosis inducer. α-Santalol activates caspase-3 to drive apoptotic processes. >α-Santalol induces apoptosis, decreases cell viability, and causes PARP cleavage in human prostate cancer cells. α-santalol inhibits Akt/Survivin pathway to induce cell death. α-Santalol can be used for the research of prostate cancer and diabetes mellitus .
Garenoxacin Mesylate hydrate
Garenoxacin Mesylate hydrate
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Cat. No.: HY-17460A
CAS No.: 223652-90-2
Synonyms: BMS284756 Mesylate hydrate
Target:  

Bacterial Topoisomerase DNA/RNA Synthesis Antibiotic

Research Areas:  

Infection

Garenoxacin (BMS284756) Mesylate hydrate is an orally active quinolone antibiotic and has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes, and fastidious organisms .
7-PPD
7-PPD
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Cat. No.: HY-176747
CAS No.: 3081-01-4
Synonyms: DMPPD
Target:  

Reactive Oxygen Species (ROS)

Research Areas:  

Others

7-PPD (DMPPD) is a rubber antioxidant that scavenges free radicals and inhibits the oxidative degradation of rubber chains. 7-PPD shows promise for research in tire manufacturing and rubber product processing .
MS39
MS39
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Cat. No.: HY-157581
CAS No.: 2675490-92-1
Purity:  99.89%
Target:  

EGFR PROTACs

Research Areas:  

Cancer

MS39 (compound 6) is a PROTAC targeting EGFR. MS39 reduces the expression of EGFR and downstream signaling in HCC-827 and H3255 cells. MS39 inhibits the proliferation of H3255 cells .
Perfluoroundecanoic acid
Perfluoroundecanoic acid
0 Images
Cat. No.: HY-W142432
CAS No.: 2058-94-8
Target:  

Biochemical Assay Reagents β-catenin Wnt Arginase TGF-beta/Smad mTOR Akt ERK Atg8/LC3 p62 Autophagy

Research Areas:  

Metabolic Disease Inflammation/Immunology Cancer

Perfluoroundecanoic acid is a perfluoroalkyl substance (PFAS). Perfluoroundecanoic acid is an orally active oxidative stress inducer. Perfluoroundecanoic acid promotes macrophage M2 polarization, activates Wnt/β-catenin signaling and enhances β-catenin nuclear accumulation. Perfluoroundecanoic acid -induced M2 phenotype macrophage accelerates tumor progression in vitro and in vivo. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy. Perfluoroundecanoic acid accelerates insulitis development in a mouse model of type 1 diabetes. Perfluoroundecanoic acid can be used for the study of ovarian cancer, type 1 diabetes and inflammation .
Assay Types