2. PI3K/Akt/mTOR Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Akt Survivin Apoptosis Caspase PARP
  4. α-Santalol

α-Santalol  (Synonyms: cis-α-Santalol)

Cat. No.: HY-N11908 Purity: 97.62%
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α-Santalol (cis-α-Santalol), a naturally occurring sesquiterpene, is an orally active anticancer agent and apoptosis inducer. α-Santalol activates caspase-3 to drive apoptotic processes. >α-Santalol induces apoptosis, decreases cell viability, and causes PARP cleavage in human prostate cancer cells. α-santalol inhibits Akt/Survivin pathway to induce cell death. α-Santalol can be used for the research of prostate cancer and diabetes mellitus.

For research use only. We do not sell to patients.

α-Santalol

α-Santalol Chemical Structure

CAS No. : 115-71-9

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α-Santalol Related Antibodies

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Akt Akt1 Akt2 Akt3

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

α-Santalol (cis-α-Santalol), a naturally occurring sesquiterpene, is an orally active anticancer agent and apoptosis inducer. α-Santalol activates caspase-3 to drive apoptotic processes. >α-Santalol induces apoptosis, decreases cell viability, and causes PARP cleavage in human prostate cancer cells. α-santalol inhibits Akt/Survivin pathway to induce cell death. α-Santalol can be used for the research of prostate cancer and diabetes mellitus[1][2][3][4].

IC50 & Target[1]

Caspase 3

 

In Vitro

α-Santalol (25-75 μM; 24-48 h) decreases viability of androgen-independent PC-3 and androgen-dependent LNCaP human prostate cancer cells in a concentration- and time-dependent manner with an IC50 < 50 μM, while normal human prostate epithelial PrEC cells are relatively resistant to its growth-suppressive effects[1].
α-Santalol (25-50 μM; 24 h) induces apoptotic DNA fragmentation in human prostate cancer PC-3 and LNCaP cells, with LNCaP cells showing greater sensitivity to this effect than PC-3 cells[1].
α-Santalol (50 μM; 24 h) induces morphological features of apoptosis, including condensed and fragmented nuclear DNA, in human prostate cancer PC-3 and LNCaP cells[1].
α-Santalol (50 μM; 24 h) activates caspase-3 in human prostate cancer PC-3 and LNCaP cells, with a more robust response observed in LNCaP cells[1].
α-Santalol (25-50 μM; 24-48 h) induces cleavage of PARP, a downstream substrate of active caspase-3, in human prostate cancer LNCaP cells[1].
α-santalol (20, 40 μM) resulted in the down regulation of survivin and p-AKT (s-473) expression and statistically significant reduction in total survivin levels in prostate cancer cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Santalol Related Antibodies

Cell Viability Assay[1]

Cell Line: PC-3 cells, LNCaP cells, PrEC cells
Concentration: 25 μM, 50 μM, 75 μM
Incubation Time: 24 h, 48 h
Result: Decreased PC-3 cell viability by ~75% after 24-h treatment with 50 μM.
Showed greater growth inhibition sensitivity in LNCaP cells than in PC-3 cells at 48 h.
Reduced PrEC cell viability by ~44% with 75 μM for 24 h, with minimal effects at 25 and 50 μM.
Achieved an IC50 < 50 μM in prostate cancer cells.

Apoptosis Analysis[1]

Cell Line: PC-3 cells, LNCaP cells
Concentration: 25 μM, 50 μM
Incubation Time: 24 h
Result: Increased cytoplasmic histone-associated DNA fragmentation statistically significantly in both PC-3 and LNCaP cells after 24-h treatment with 50 μM, with an enrichment factor of ~3 in PC-3 cells and ~6 in LNCaP cells.

Apoptosis Analysis[1]

Cell Line: PC-3 cells, LNCaP cells
Concentration: 50 μM
Incubation Time: 24 h
Result: Increased the percentage of apoptotic cells with condensed/fragmented DNA statistically significantly after 24-h treatment, which were rarely observed in control cultures.

Western Blot Analysis[1]

Cell Line: LNCaP cells
Concentration: 25 μM, 50 μM
Incubation Time: 24-48 h
Result: Induced strong expression of cleaved 89 kDa PARP in LNCaP cell lysates.
Increased expression of cleaved 89 kDa PARP at 48 h compared to 24 h.
In Vivo

α-Santalol (2.5-5% (w/v); topical application) exerts significant chemopreventive activity against chemically and UVB-induced skin carcinogenesis in Mus musculus, with no observed carcinogenic effects at these doses[1].
α-Santalol (12.5-200 mg/kg; 100-200 μg/10 μL; i.p.; p.o.; i.c.v.; single dose) dose-dependently induces central nervous system depressant effects in male ddY mice, including up to 95% reduction in spontaneous locomotor activity at 50 mg/kg i.p., 95% inhibition of acetic acid-induced writhing at 50 mg/kg i.p., and significant increases in hexobarbital-induced sleeping time, hypothermia, and brain HVA/5-HIAA levels at higher doses[2].
α-Santalol (100 mg/kg BW; i.p.) reduces blood glucose by 61% and modulates associated physiological and biochemical parameters to normoglycemic levels in Alloxan (HY-W017227)-induced diabetic male Swiss albino mice[3].
α-Santalol (100 mg/kg BW; i.p.) increases body weight by 27.75% and modulates key oxidative stress and liver function parameters in d-galactose-induced oxidative stress male Swiss albino mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ddY mice (male, 23-30 g, 8 per group)[2]
Dosage: 12.5-50 mg/kg (i.p.); 25-200 mg/kg (p.o.); 100-200 μg/10 μl (i.c.v.)
Administration: i.p.; p.o.; i.c.v.; single dose
Result: Increased hexobarbital-induced sleeping time .
Reduced acetic acid-induced writhing number.
Reduced Methamphetamine-induced locomotor activity across all intervals.
Increased brain homovanillic acid (HVA) levels to 171% of control.
Produced no significant effect on Reserpine-induced hypothermia.
Produced no significant anticonvulsant effects in chemically-induced or electroshock-induced seizure models (50 mg/kg i.p. and 200 mg/kg p.o.).
Animal Model: Swiss albino (male, adult 4 months old, 20-30 g, alloxan-induced diabetic)[3]
Dosage: 100 mg/kg BW
Administration: i.p.
Result: Increased body weight by 8.1%.
Reduced water consumption by 89%.
Reduced serum bilirubin by 42.9%.
Reduced serum malondialdehyde (MDA) by 46.1%.
Reduced liver weight by 36.3%.
Increased liver glycogen by 87.4%.
Increased total liver protein by 23.5%.
Reduced blood glucose levels by 61% over 8 days, returning blood glucose to normoglycemic levels (93 ± 9 mg/dl on Day 8).
Molecular Weight

220.35

Formula

C15H24O
CAS No.
Appearance

Liquid (Density: 0.977 g/cm3)

Color

Colorless to light yellow

SMILES

CC12C(C3)[C@@H]1CC3[C@](C)2CC/C=C(C)\CO
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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α-Santalol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Santalol115-71-9cis-α-SantalolAktSurvivinApoptosisCaspasePARPPKBProtein kinase Bpoly ADP ribose polymerasecaspase-3alloxan-induced diabetic male Swiss albino micemouse brainnormal human prostate epithelial PrEC cellsd-galactose-mediated oxidative stress-induced male Swiss albino micehuman prostate cancer PC-3 cellshuman prostate cancer cellshuman prostate cancer LNCaP cellsskin cancersInhibitorinhibitorinhibit

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