14 Results for "

TMPRSS6

" in MedChemExpress (MCE) Product Catalog:
Products (14)

14 Results for "TMPRSS6" in MCE Product Catalog:

Referencia número: HY-177662
No. CAS: 2273007-95-5
Synonyms: IONIS-TMPRSS6-Lrx; ISIS 702843
Target:  

TMPRSS6

Áreas de investigación:  

Metabolic Disease

Sapablursen, an antisense oligonucleotide, is designed to reduce the production of TMPRSS6 resulting in increased expression of hepcidin, which is the key regulator of iron homeostasis. Sapablursen can be used in the research of blood diseases such as pol
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Referencia número: HY-130136A
Target:  

Ser/Thr Protease

Áreas de investigación:  

Others

TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). TMPRSS6, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice .
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Referencia número: HY-130136
No. CAS: 2088415-78-3
Target:  

Ser/Thr Protease

Áreas de investigación:  

Others

TMPRSS6-IN-1 (compound 8) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). TMPRSS6, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice .
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Referencia número: HY-147278
No. CAS: 2646704-10-9
Synonyms: Divesiran; SLN124
Manusiran (Divesiran) is a GalNac-siRNA targeting liver and transmembrane serine protease 6 (Serine protease 6). Manusiran increases hepatic Hepcidin synthesis and plasma levels by silencing TMPRSS6, a negative regulator of hepcidin production, and limits the availability of iron required for erythropoiesis. Combined use of Manusiran with Deferiprone (HY-B0568) reduces ineffective erythropoiesis and hepatic iron overload in a mouse model of β-thalassemia. Manusiran can be used for research on polycythemia vera, type 1 hereditary hemochromatosis, and β-thalassemia .
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Referencia número: HY-177662A
No. CAS: 2273008-00-5
Synonyms: IONIS-TMPRSS6-Lrx sodium; ISIS 702843 sodium
Target:  

TMPRSS6

Áreas de investigación:  

Metabolic Disease

Sapablursen sodium, an antisense oligonucleotide, is designed to reduce the production of TMPRSS6 resulting in increased expression of hepcidin, which is the key regulator of iron homeostasis. Sapablursen sodium can be used in the research of blood diseas
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Referencia número: HY-RS19286
Áreas de investigación:  

Others

Tmprss6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tmprss6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Referencia número: HY-P11260
No. CAS: 3051556-89-6
Áreas de investigación:  

Metabolic Disease

MD5 is a selective TMPRSS6 mimetic peptide inhibitor with an IC50 for recombinant human TMPRSS6 protein of 22 nM and a Ki of 3.4 nM. MD5 exhibits the significantly reduced inhibitory effect on Matriptase, with an IC50 of 352 nM and a Ki of 99.2 nM. MD5 exhibits good target specificity and only has a weak inhibitory effect on thrombin (Thrombin), with Ki of 120 nM. MD5 demonstrates good initial drugability and can be used for the study of iron overload diseases (such as hereditary hemochromatosis, β-thalassemia) .
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Referencia número: HY-RS14773
Áreas de investigación:  

Others

TMPRSS6 Human Pre-designed siRNA Set A contains three designed siRNAs for TMPRSS6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Referencia número: HY-RS25776
Áreas de investigación:  

Others

Tmprss6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tmprss6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Referencia número: HY-147278A
Synonyms: Divesiran sodium; SLN124 sodium
Manusiran sodium (Divesiran sodium) is a GalNac-siRNA targeting liver and transmembrane serine protease 6 (Serine protease 6). Manusiran sodium increases hepatic Hepcidin synthesis and plasma levels by silencing TMPRSS6, a negative regulator of hepcidin production, and limits the availability of iron required for erythropoiesis. Combined use of Manusiran sodium with Deferiprone (HY-B0568) reduces ineffective erythropoiesis and hepatic iron overload in a mouse model of β-thalassemia. Manusiran sodium can be used for research on polycythemia vera, type 1 hereditary hemochromatosis, and β-thalassemia .
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Referencia número: HY-P991637
No. CAS: 2996101-49-4
Synonyms: REGN7999

Target:  

Ser/Thr Protease

Áreas de investigación:  

Metabolic Disease

REGN7999 is a monoclonal antibody that inhibits TMPRSS6. REGN7999 inhibits TMPRSS6 activity, preventing Hemojuvelin (HJV) lysis, thereby enhancing BMP6-HJV signaling and increasing serum hepcidin. REGN7999 ameliorates iron overload and impaired erythropoiesis in a β-thalassemia mouse model by inhibiting TMPRSS6 activity. REGN7999 is indicated for research in β-thalassemia .
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Referencia número: HY-180217
Target:  

TMPRSS6 Factor Xa

Áreas de investigación:  

Cardiovascular Disease

WGU55 is a selective and potent reversible type II transmembrane serine protease TMPRSS6 inhibitor with a Ki of 12.15 nM. WGU55 inhibits TMPRSS6 activity with an IC50 of 138 nMin KEK293 cells. WGU55 has a Ki of 3510 nM (SI = 289) against the homologous protease matriptase and a Ki of 5.2 μM against the coagulation key protease Factor Xa. WGU55 can be used for the research of iron overload related diseases, such as hereditary hemochromatosis .
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Referencia número: HY-P992451
Synonyms: KY1066
RLYB331 (KY1066) is a is a monoclonal antibody targeting Matriptase-2 (TMPRSS6) . RLYB331 binds to the serine protease active site of matriptase-2, blocking protease activity to increase hepcidin expression. RLYB331 reduces iron overload, inhibits α-aggregates, reduces ROS, inhibits apoptosis, and enhances erythroid differentiation. RLYB331 ameliorates ineffective erythropoiesis in β-thalassemic mouse models. RLYB331 can be used for the research of β-thalassemia .
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Referencia número: HY-P89613
Synonyms: UNQ354/PRO618, TMPRSS6, Transmembrane protease serine 6, Matriptase-2

Host:  

Mouse

Application:  

WB, ICC/IF, IF-Tissue, IP, ELISA

Reactivity:  

human

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