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Results for "

TMPRSS6

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TMPRSS6 (5) Apoptosis (1) Factor Xa (1) Hepcidin (1) Reactive Oxygen Species (ROS) (1) Ser/Thr Protease (8) Small Interfering RNA (siRNA) (5) Thrombin (1)
By Research Areas:	Cardiovascular Disease (3) Metabolic Disease (5)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) siRNA drugs (2) Human Pre-designed siRNA Sets (1) Antisense Oligonucleotides (2) siRNAs (5)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Oligonucleotides

Targets Recommended: TMPRSS6 Enteropeptidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-177662

Sapablursen IONIS-TMPRSS6-Lrx; ISIS 702843	TMPRSS6	Metabolic Disease
Sapablursen, an antisense oligonucleotide, is designed to reduce the production of TMPRSS6 resulting in increased expression of hepcidin, which is the key regulator of iron homeostasis. Sapablursen can be used in the research of blood diseases such as pol

HY-130136A

TMPRSS6-IN-1 TFA	Ser/Thr Protease	Others
TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). *TMPRSS6*, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice .

HY-130136

TMPRSS6-IN-1	Ser/Thr Protease	Others
TMPRSS6-IN-1 (compound 8) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). *TMPRSS6*, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice .

HY-147278

Manusiran Divesiran; SLN124	Ser/Thr Protease Small Interfering RNA (siRNA) TMPRSS6	Cardiovascular Disease
Manusiran (Divesiran) is a GalNac-siRNA targeting liver and transmembrane serine protease 6 (Serine protease 6). Manusiran increases hepatic Hepcidin synthesis and plasma levels by silencing *TMPRSS6*, a negative regulator of hepcidin production, and limits the availability of iron required for erythropoiesis. Combined use of Manusiran with Deferiprone (HY-B0568) reduces ineffective erythropoiesis and hepatic iron overload in a mouse model of β-thalassemia. Manusiran can be used for research on polycythemia vera, type 1 hereditary hemochromatosis, and β-thalassemia .

HY-177662A

Sapablursen sodium IONIS-TMPRSS6-Lrx sodium; ISIS 702843 sodium	TMPRSS6	Metabolic Disease
Sapablursen sodium, an antisense oligonucleotide, is designed to reduce the production of TMPRSS6 resulting in increased expression of hepcidin, which is the key regulator of iron homeostasis. Sapablursen sodium can be used in the research of blood diseas

HY-RS19286

Tmprss6 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tmprss6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tmprss6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tmprss6 Mouse Pre-designed siRNA Set A Tmprss6 Mouse Pre-designed siRNA Set A

HY-P11260

MD5	Ser/Thr Protease Thrombin	Metabolic Disease
MD5 is a selective *TMPRSS6* mimetic peptide inhibitor with an IC₅₀ for recombinant human TMPRSS6 protein of 22 nM and a K_i of 3.4 nM. MD5 exhibits the significantly reduced inhibitory effect on Matriptase, with an IC₅₀ of 352 nM and a K_i of 99.2 nM. MD5 exhibits good target specificity and only has a weak inhibitory effect on thrombin (Thrombin), with K_i of 120 nM. MD5 demonstrates good initial drugability and can be used for the study of iron overload diseases (such as hereditary hemochromatosis, β-thalassemia) .

HY-RS25776

Tmprss6 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tmprss6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tmprss6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tmprss6 Rat Pre-designed siRNA Set A Tmprss6 Rat Pre-designed siRNA Set A

HY-RS14773

TMPRSS6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TMPRSS6 Human Pre-designed siRNA Set A contains three designed siRNAs for TMPRSS6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TMPRSS6 Human Pre-designed siRNA Set A TMPRSS6 Human Pre-designed siRNA Set A

HY-147278A

Manusiran sodium Divesiran sodium; SLN124 sodium	Ser/Thr Protease Small Interfering RNA (siRNA) TMPRSS6	Others
Manusiran (SLN124) sodium, a GalNAc conjugated 19-mer siRNA targeting *TMPRSS6* (transmembrane protease serine 6), reduces plasma iron and increases hepcidin levels ^[1][2].

HY-P991137

Exerenibart	Ser/Thr Protease	Metabolic Disease
Exerenibart is an immunoglobulin G4-κ monoclonal antibody targeting human transmembrane serine protease 6 (TMPRSS6). Exerenibart is promising for research of diseases associated with iron metabolism disorders, such as iron overload or iron deficiency .

HY-P991637

REGN7999	Ser/Thr Protease	Metabolic Disease
REGN7999 is a monoclonal antibody that inhibits *TMPRSS6. REGN7999 inhibits TMPRSS6* activity, preventing Hemojuvelin (HJV) lysis, thereby enhancing BMP6-HJV signaling and increasing serum hepcidin. REGN7999 ameliorates iron overload and impaired erythropoiesis in a β-thalassemia mouse model by inhibiting TMPRSS6 activity. REGN7999 is indicated for research in β-thalassemia .

HY-180217

WGU55	TMPRSS6 Factor Xa	Cardiovascular Disease
WGU55 is a selective and potent reversible type II transmembrane serine protease TMPRSS6 inhibitor with a K_i of 12.15 nM. WGU55 inhibits TMPRSS6 activity with an IC₅₀ of 138 nMin KEK293 cells. WGU55 has a K_i of 3510 nM (SI = 289) against the homologous protease matriptase and a K_i of 5.2 μM against the coagulation key protease Factor Xa. WGU55 can be used for the research of iron overload related diseases, such as hereditary hemochromatosis .

HY-P992451

RLYB331 KY1066	Ser/Thr Protease Hepcidin Reactive Oxygen Species (ROS) Apoptosis	Cardiovascular Disease
RLYB331 (KY1066) is a is a monoclonal antibody targeting Matriptase-2 (TMPRSS6) . RLYB331 binds to the serine protease active site of matriptase-2, blocking protease activity to increase hepcidin expression. RLYB331 reduces iron overload, inhibits α-aggregates, reduces ROS, inhibits apoptosis, and enhances erythroid differentiation. RLYB331 ameliorates ineffective erythropoiesis in β-thalassemic mouse models. RLYB331 can be used for the research of β-thalassemia .

Cat. No.	Product Name	Target	Research Area