36 Results for "

TNFR2

" in MedChemExpress (MCE) Product Catalog:
Products (36)

36 Results for "TNFR2" in MCE Product Catalog:

27
27 Publications Verification
Cat. No.: HY-P9970
CAS No.: 170277-31-3
Synonyms: Avakine; CT-P13; SB2; TA-650
Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research [2].
The component ratio of this product is Active ingredient : Excipients = 9 : 47.
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27
27 Publications Verification
Cat. No.: HY-P9970A
Synonyms: Avakine (Anti-TNF-α); CT-P13 (Anti-TNF-α)
Infliximab (Anti-TNF-α) (Avakine (Anti-TNF-α)) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab (Anti-TNF-α) prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab (Anti-TNF-α) has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research [2].
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13
13 Cited Publications
Cat. No.: HY-P1860
CAS No.: 144796-71-4
Research Areas:  

Inflammation/Immunology Cancer

TNF-α (31-45), human is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis [2] .
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13
13 Cited Publications
Cat. No.: HY-P1860A
Research Areas:  

Inflammation/Immunology

TNF-α (31-45), human TFA is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis [2] .
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1
1 Cited Publications
Cat. No.: HY-P72025
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; CD120b; Etanercept; TBP-2; TBPII;
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Cat. No.: HY-160412
CAS No.: 2248726-53-4
Synonyms: SAR-441566; TNFα activity modulator 3
Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Balinatunfib (SAR-441566) is an orally active inhibitor of TNFR1 signaling. By binding to the central pocket of the soluble TNFα (sTNFα) trimer, Balinatunfib stabilizes an asymmetric conformation, blocking its binding to TNFR1 (without affecting TNFR2) and thus inhibiting downstream pathways. Balinatunfib has anti-inflammatory activity, and can be used in the study of autoimmune diseases [2].
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Cat. No.: HY-P991049
Synonyms: ATM-001

Target:  

TNF Receptor

Atrosimab is an Fv-Fc1K fusion protein with an EC50 value of 0.37 nM against humans. Atrosimab inhibits TNF-induced TNFR1 activation, release of IL-6 and IL-8, and cell death, and alleviates neuroinflammation. Atrosimab is applicable to research related to inflammatory diseases, neurodegenerative diseases, acute and chronic inflammation, experimental arthritis, non-alcoholic steatohepatitis, and experimental autoimmune encephalomyelitis [2] .
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Cat. No.: HY-P99149

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

Anti-Mouse TNFR2 Antibody (TR75-54.7) is an anti-mouse TNFR2 IgG monoclonal antibody. Anti-Mouse TNFR2 Antibody (TR75-54.7) can reduce white blood cell count (WBC) and decrease the expression of some pro-inflammatory cytokines such as CCL2 and CXCL5. Anti-Mouse TNFR2 Antibody (TR75-54.7) can be used for researches on inflammation conditions and cancer such as breast cancer [2].
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Cat. No.: HY-P991400
GSK1995057 is a human monoclonal antibody (mAb) targeting TNFRSF1A. GSK1995057 selectively binds to TNFR1, blocks the binding of TNF-α and LT-α, and does not interfere with TNFR2 signaling. GSK1995057 inhibits the activation of NF-κB, JNK and MAPK pathways, alleviates apoptosis (apoptosis) and inflammatory responses (inhibiting IL-1β, IL-6, IL-10, TNF-α), and prevents viability loss of human nucleus pulposus cells. GSK1995057 inhibits the expression of cytokines and neutrophil adhesion molecules in human pulmonary microvascular endothelial cell monolayers, and reduces inflammatory responses and lung injury symptoms in non-human primates. GSK1995057 forms complexes with HAVH autoantibodies, thereby activating TNFR1 and triggering the release of cytokines and IL-8 in human cells. GSK1995057 can be used in research related to intervertebral disc degeneration and acute lung injury [2] .
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Cat. No.: HY-P991192

Target:  

TNF Receptor

Research Areas:  

Cancer

BI-1808 is a human IgG1 monoclonal antibody that targets TNFR2by blocking interaction of TNFR2 with ligand TNF-α, confers FcγR-dependent depletion of Treg and mediates expansion of intratumoral CD8 + T cells .
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Cat. No.: HY-124339
CAS No.: 2092913-64-7
JNJ525 is a TNFα inhibitor with IC50 values of 1.2 μM and 1.1 μM against TNFR1 and TNFR2, respectively. JNJ525 forms ordered aggregates and induces quaternary structural transition of TNFα, thereby blocking the protein-protein interaction between TNFα and its receptors. The inhibitory activity of JNJ525 is completely lost in the presence of 0.1% Triton X-100 .
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Cat. No.: HY-P991195
Synonyms: SIM1811-03

Target:  

TNF Receptor

Research Areas:  

Cancer

SIM-0235 is humanized immunoglobulin G1 (IgG1) monoclonal antibody that targets and inhibits TNFR2, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) [1].
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Cat. No.: HY-P992399

Target:  

TNF Receptor NF-κB

Research Areas:  

Cancer

LBL-019 is a humanized IgG1 monoclonal antibody targeting TNFR2. LBL-019 costimulates TNFR2 and activates the NF-κB signaling pathway in an Fc crosslinking-dependent manner. LBL-019 can be used for the research of advanced malignant tumors, including hepatocellular carcinoma and melanoma. The recommended isotype control is human IgG1 kappa (HY-P99001) .
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Cat. No.: HY-P78526
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CD120b; Etanercept; p75TBPII; p75TNFR; TNF RII; TNF-R2; TNF-R75; TNFR80; TNFRSF1B; TNFR2; TBPII; TNFBR; TNFR1B
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Cat. No.: HY-P701084
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD120b; Etanercept; p75TBPII; p75TNFR; TNF RII; TNF-R2; TNF-R75; TNFR80; TNFRSF1B; TNFR2; TBPII; TNFBR; TNFR1B
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Cat. No.: HY-P76683
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNF-R2; CD120b; Tumor necrosis factor receptor superfamily member 1b; p75; TNFR2
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Cat. No.: HY-P76108
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNF-R2; CD120b; Tumor necrosis factor receptor superfamily member 1b; p75; TNFR2
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Cat. No.: HY-P705102
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD120b; Etanercept; p75TBPII; p75TNFR; TNF RII; TNF-R2; TNF-R75; TNFR80; TNFRSF1B; TNFR2; TBPII; TNFBR; TNFR1B
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Cat. No.: HY-P77498
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNF-R2; CD120b; Tumor necrosis factor receptor superfamily member 1b; p75; TNFR2
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Cat. No.: HY-P72444
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNF-R2; CD120b; Tumor necrosis factor receptor superfamily member 1b; p75; TNFR2
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