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Results for "

TOP2B

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-174374
    Topobexin

    		Topoisomerase Cardiovascular Disease
    Topobexin is a TOP2B-selective inhibitor with IC50 values of 0.19 μM and 4.8 μM for TOP2B and TOP2A (DNA decatenation assay). Topobexin binds to non-homologous residues in the obex pocket and targets the ATPase domain of TOP2B. Topobexin prevents anthracycline-induced DNA double-strand break formation, apoptotic signaling mediated by caspase 3/7, 8 and 9, cardiomyocyte morphological changes, mitochondrial depolarization/loss, left ventricular systolic dysfunction, extracellular matrix remodeling, fibrotic alterations, and increases in plasma cardiac troponin T and BNP. Topobexin does not impair the antiproliferative effects of anthracyclines in cancer cells, exhibits no intrinsic cytotoxicity in cardiomyocytes, and is well tolerated in rabbits. Topobexin can be used in studies related to anthracycline-induced cardiotoxicity [2] .
    Topobexin
  • HY-RS14897
    TOP2B Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TOP2B Human Pre-designed siRNA Set A contains three designed siRNAs for TOP2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TOP2B Human Pre-designed siRNA Set A
    TOP2B Human Pre-designed siRNA Set A
  • HY-123393
    PNU-142586

    		Topoisomerase Others
    PNU-142586 is the major metabolite of Linezolid (HY-10394). PNU-142586 can inhibit the activity of DNA topoisomerase 2-α (TOP2A) and DNA topoisomerase 2-β (TOP2B). PNU-142586 interferes with DNA replication and transcription by blocking the binding of DNA to TOP2 and inhibiting ATP hydrolysis, ultimately leading to antiproliferative and cytotoxic effects, including mitochondrial dysfunction. PNU-142586 can be used to study Linezolid-induced hematotoxicity and its molecular mechanism .
    PNU-142586
  • HY-RS20119
    Top2b Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Top2b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Top2b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Top2b Mouse Pre-designed siRNA Set A
    Top2b Mouse Pre-designed siRNA Set A
  • HY-RS26623
    Top2b Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Top2b Rat Pre-designed siRNA Set A contains three designed siRNAs for Top2b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Top2b Rat Pre-designed siRNA Set A
    Top2b Rat Pre-designed siRNA Set A
  • HY-175834
    DNA/TOP2A-IN-1

    		Topoisomerase Reactive Oxygen Species (ROS) Apoptosis Microtubule/Tubulin Cancer
    DNA/TOP2A-IN-1 is an inhibitor of DNA and TOP2A. DNA/TOP2A-IN-1 selectively binds to TOP2A, not TOP2B, and interacts with DNA and TOP2A to form a stable DM1-TOP2A-DNA ternary complex. DNA/TOP2A-IN-1 induces DNA damage, increases reactive oxygen species (ROS) and triggers apoptosis in triple-negative breast cancer (TNBC) cells. DNA/TOP2A-IN-1 disrupts microtubule distribution and induces cell cycle arrest. DNA/TOP2A-IN-1 shows strong antiproliferative activity and inhibits cell migration. DNA/TOP2A-IN-1 inhibits tumor growth and can be used for TNBC research .
    DNA/TOP2A-IN-1
  • HY-W654323
    PNU-142586 sodium

    		Topoisomerase Drug Metabolite Others
    PNU-142586 sodiu) is the major metabolite of Linezolid (HY-10394). PNU-142586 can inhibit the activity of DNA topoisomerase 2-α (TOP2A) and DNA topoisomerase 2-β (TOP2B). PNU-142586 interferes with DNA replication and transcription by blocking the binding of DNA to TOP2 and inhibiting ATP hydrolysis, ultimately leading to antiproliferative and cytotoxic effects, including mitochondrial dysfunction. PNU-142586 can be used to study Linezolid-induced hematotoxicity and its molecular mechanism .
    PNU-142586 sodium

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