14 Results for "

TSLP receptor

" in MedChemExpress (MCE) Product Catalog:
Products (14)

14 Results for "TSLP receptor" in MCE Product Catalog:

Cat. No.: HY-P99366A
CAS No.: 1572943-04-4
Synonyms: AMG 157 (anti-TSLP); MEDI 19929 (anti-TSLP); Tezepelumab-ekko (anti-TSLP)

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Tezepelumab (anti-TSLP) is human monoclonal antibody (IgG2λ) that binds specifically to TSLP, blocking it from interacting with its heterodimeric receptor. Tezepelumab can be used for the research of severe, uncontrolled asthma .
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Cat. No.: HY-P990774
CAS No.: 2768386-15-6
Synonyms: ASP-7266; TRAB-1; UPB-101

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Verekitug (ASP-7266; TRAB-1; UPB-101) is a human monoclonal antibody targeting the thymic stromal lymphopoietin receptor (TSLPR), with a mean half-life of approximately 20 days. At doses of Verekitug ≥100 mg, complete and sustained TSLPR-specific occupancy is achieved, and the antibody does not bind to IL-7Rα. By inhibiting TSLP-driven inflammatory responses, Verekitug blocks TSLP-induced cell proliferation and TARC expression, while reducing fractional exhaled NO levels, blood eosinophil counts, and levels of IL-5 and IgE. Verekitug significantly improves scores for nasal polyps, nasal congestion and olfactory dysfunction, with favorable safety and good tolerability; potential adverse reactions include headache, upper respiratory tract infection, sinusitis and nasopharyngitis. Verekitug is used in relevant studies on asthma, chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease .
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Cat. No.: HY-P990023
CAS No.: 2622254-57-1
Synonyms: ADX-914
Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Bempikibart (ADX-914) is a fully human IgG1-κ monoclonal antibody targeting IL-7Rα. Bempikibart binds to the IL-7 receptor alpha and blocks IL-7 and TSLP signaling. Bempikibart reduces T cell populations while relatively preserving regulatory T cells. Bempikibart inhibits Th1, Th2, and Th17 immune pathways. Bempikibart can be used in research on alopecia areata and atopic dermatitis .
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Cat. No.: HY-P991720
CAS No.: 2985643-31-8

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Tepilukimig is a bivalent humanized IgG1κ monoclonal antibody inhibitor targeting TSLP-IL7Rα and TSLP-CRLF2. Tepilukimig inhibits the binding of TSLP to its receptors (IL7Rα and CRLF2) on the cell surface, thereby completely interrupting the inflammatory signaling pathway driven by TSLP. Tepilukimig can be used for allergic and inflammatory diseases like atopic dermatitis and asthma research .
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Cat. No.: HY-P705242
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRLF2; IL-XR; Cytokine receptor Like Factor 2; Thymic Stromal-Derived Lymphopoietin receptor; TSLPR; Cytokine receptor CRL2 Precusor; CRL2; Cytokine receptor-Like 2; Thymic Stromal Lymphopoietin Protein receptor; CRLF2Y; Cytokine receptor-Like Factor 2; P2RY8; TSLP receptor; ILXR
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P70794
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CRLF2; IL-XR; Cytokine receptor Like Factor 2; Thymic Stromal-Derived Lymphopoietin receptor; TSLPR; Cytokine receptor CRL2 Precusor; CRL2; Cytokine receptor-Like 2; Thymic Stromal Lymphopoietin Protein receptor; CRLF2Y; Cytokine receptor-Like Factor 2; P2RY8; TSLP receptor; ILXR
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P700842
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CRLF2; IL-XR; Cytokine receptor Like Factor 2; Thymic Stromal-Derived Lymphopoietin receptor; TSLPR; Cytokine receptor CRL2 Precusor; CRL2; Cytokine receptor-Like 2; Thymic Stromal Lymphopoietin Protein receptor; CRLF2Y; Cytokine receptor-Like Factor 2; P
Species:  
Cynomolgus
Source:  
HEK293
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Cat. No.: HY-P70823
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CRLF2; IL-XR; Cytokine receptor Like Factor 2; Thymic Stromal-Derived Lymphopoietin receptor; TSLPR; Cytokine receptor CRL2 Precusor; CRL2; Cytokine receptor-Like 2; Thymic Stromal Lymphopoietin Protein receptor; CRLF2Y; Cytokine receptor-Like Factor 2; P
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P70989
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CRLF2; IL-XR; Cytokine receptor Like Factor 2; Thymic Stromal-Derived Lymphopoietin receptor; TSLPR; Cytokine receptor CRL2 Precusor; CRL2; Cytokine receptor-Like 2; Thymic Stromal Lymphopoietin Protein receptor; CRLF2Y; Cytokine receptor-Like Factor 2; P
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P71389
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CRLF2; IL-XR; Cytokine receptor Like Factor 2; Thymic Stromal-Derived Lymphopoietin receptor; TSLPR; Cytokine receptor CRL2 Precusor; CRL2; Cytokine receptor-Like 2; Thymic Stromal Lymphopoietin Protein receptor; CRLF2Y; Cytokine receptor-Like Factor 2; P
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P992378

Target:  

CCR STAT

Research Areas:  

Inflammation/Immunology Cancer

HZ-1127 is a thymic stromal lymphopoietin (TSLP) inhibitor. HZ-1127 selectively binds to TSLP, blocks receptor complex interaction, inhibits STAT5 activation, downstream inflammatory signaling, and TSLP-induced CCL17 and CCL22 secretion. HZ-1127 can be used for the research of allergic diseases and cancer .
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Cat. No.: HY-P992452

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

RO-5469754 is a humanized monoclonal antibody that specifically binds to human thymic stromal lymphopoietin (TSLP). RO-5469754 blocks the binding of hTSLP to its receptor complex, thereby neutralizing TSLP-mediated biological activities, and does not cross-react with TSLP from cynomolgus monkeys or mice. RO-5469754 can be further used to generate the bispecific antibody TAVO101 × IL4R-dupi .
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Cat. No.: HY-206870
CAS No.: 3104965-33-2
Research Areas:  

Inflammation/Immunology

BP79 is a potent TSLP receptor inhibitor. BP79 disrupts TSLP-mediated ternary complex formation, blocks TSLPR-IL7Rα co-localization, binds and stabilizes TSLPR, and inhibits phosphorylated STAT3/6. BP79 suppresses immune cell infiltration, secretion of IL-13, IL-4. BP79 can be used for the research of inflammation diseases, such as atopic dermatitis, allergic asthma, and allergic rhinitis .
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Cat. No.: HY-P704719
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL7R; Soluble Interleukin-7 receptor; Interleukin 7 receptor; IL-7 receptor Subunit Alpha; CDw127; IL-7R Subunit Alpha; Interleukin-7 receptor Subunit Alpha; CD127 Antigen; IL-7Ralpha; IL-7R-Alpha; IL7Ralpha; Interleukin 7 receptor Alpha Chain; Lnc-IL7R;
Species:  
Human
Source:  
HEK293
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