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13 Results for "
UBA1
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "UBA1" in MCE Product Catalog:
89
89 Publications Verification
Synonyms: MLN7243
Target:
Research Areas:
TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis [1] .
2
2 Cited Publications
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PYZD-4409 is a specific inhibitor of the ubiquitin-activating enzyme UBA1 with an IC50 of 20 μM (cell-free enzymatic assay). PYZD-4409 induces cell death in malignant cells and preferentially inhibits the clonogenic growth of primary acute myeloid leukemia cells [1].
2
2 Cited Publications
Cat. No.: HY-P74485
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Ubiquitin-like modifier-activating enzyme 1; Protein A1S9; UBA1; A1S9T; UBE1
Species:
Source:
Cat. No.: HY-103436
CAS No.: 13116-77-3
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NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC50 of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC50=13 μM) but has no effect on ubiquitin adenylation [1].
Cat. No.: HY-RS24221
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Uba1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Uba1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS15319
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UBA1 Human Pre-designed siRNA Set A contains three designed siRNAs for UBA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17754
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Research Areas:
Uba1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Uba1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P705503
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Ubiquitin-like modifier-activating enzyme 1; Protein A1S9; UBA1; A1S9T; UBE1
Species:
Source:
Cat. No.: HY-P704950
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Ubiquitin-like modifier-activating enzyme 1; Protein A1S9; UBA1; A1S9T; UBE1
Species:
Source:
Cat. No.: HY-RS19646
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Uba2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Uba2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-100487R
CAS No.: 1450833-55-2
Synonyms: MLN7243 (Standard)
Research Areas:
TAK-243 (Standard) is the analytical standard of TAK-243 (HY-100487). This product is intended for research and analytical applications. TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
