Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
VBC complex
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "VBC complex" in MCE Product Catalog:
1
1 Cited Publications
Research Areas:
CP5V is a Cdc20 PROTAC degrader with a DC50 of 1.6 μM and a Kd value of 12.4 μM. CP5V couples Cdc20 with the VHL/VBC complex, triggering its ubiquitination and proteasomal degradation, thereby reducing the protein levels of Cdc20 and securin. CP5V induces mitotic arrest, inhibits cell proliferation, resensitizes Paclitaxel-resistant breast cancer cells, and suppresses breast tumor progression in xenograft models. CP5V inhibits excessive proliferation and induces apoptosis in pulmonary arterial hypertension smooth muscle cells and fibroblasts. CP5V can be used in studies related to breast cancer and pulmonary arterial hypertension .
Cat. No.: HY-161882
CAS No.: 2669027-50-1
Target:
Research Areas:
PROTAC SMARCA2 degrader-8 is a SMARCA2 PROTAC degrader with a DC50 of 28 nM in A375 cells. PROTAC SMARCA2 degrader-8 forms a crystallizable ternary complex with the SMARCA4 bromodomain and VBC, promoting the ubiquitination and proteasomal degradation of SMARCA2. PROTAC SMARCA2 degrader-8 can be used in melanoma research .
Cat. No.: HY-P12398
CAS No.: 869370-29-6
Research Areas:
F-P564 is a FITC (HY-66019)-labeled HIF-1α-derived peptide substrate used to monitor PHD2 prolyl hydroxylase activity. F-P564 undergoes PHD2-mediated hydroxylation of Pro-564 to generate a hydroxyproline-containing peptide, which binds the VBC complex, increasing mass and enhancing fluorescence polarization in the assay. The unhydroxylated form of F-P564 shows no change in fluorescence polarization upon addition of VBC .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
