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Zeaxanthin

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By Targets:	Adiponectin Receptor (1) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (1) Drug Derivative (1) Endogenous Metabolite (1) Epigenetic Reader Domain (1) P2X Receptor (1) Photosystem II (1) PROTACs (1) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (4)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120318

*Zeaxanthin* 2 Publications Verification	Endogenous Metabolite	Inflammation/Immunology Cancer
Zeaxanthin, a diet-obtained carotenoid, presents in the macula region of the eye. Zeaxanthin shows antioxidant effects .

HY-N9182

Zeaxanthin dipalmitate Physalien	Adiponectin Receptor P2X Receptor Autophagy	Inflammation/Immunology
Zeaxanthin dipalmitate (Physalien) is a wolfberry-derived carotenoid, has anti-inflammatory and anti-oxidative stress effects. Zeaxanthin dipalmitate directly interact with p2X7 receptor (K_d=81.2 nM) and adiponectin receptor 1 (AdipoR1; K_d=533 nM) in a positive dose-dependent manner. Zeaxanthin dipalmitate restores mitochondrial autophagy functions suppressed by ethanol intoxication. Zeaxanthin dipalmitate can be used in the research of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP) .

HY-107425A

cis-MZ 1	PROTACs Epigenetic Reader Domain	Cancer
cis-MZ 1 is a cis isomer of meso-zeaxanthin, a xanthophyll carotenoid component of total zeaxanthin measured in serum and egg yolks.cis-MZ 1 is a triphenyltin benzoate that adopts either a tetrahedral monomeric structure (I) or a trans-SnR₃O₂ polymeric structure (III), with structure determined by a balance of steric and electronic factors .

HY-N10991

Crocetin dialdehyde	Drug Derivative	Others
Crocetin dialdehyde is a non-volatile apocarotenoid obtained by the action of the plastidic enzyme CCD2 over the carotenoid zeaxanthin in saffron. Crocetin dialdehyde can be converted into Crocetin (HY-N2072) by aldehyde dehydrogenases (ALDHs). Crocetin dialdehyde has no effect on the liver in mice .

HY-N9625

Violaxanthin	Photosystem II	Others
Violaxanthin is a lipophilic epoxy carotenoid and a light energy scavenger with biological activities such as antioxidation and anti-inflammation. Violaxanthin exists in photosynthetic eukaryotes including higher plants and participates in the xanthophyll cycle. As a component of the xanthophyll cycle, violaxanthin can be synthesized from zeaxanthin under the catalysis of epoxidase and scavenge excess light energy in photosynthetic eukaryotes .

HY-167632

meso-Zeaxanthin (3R,3′S)-Zeaxanthin	Reactive Oxygen Species (ROS)	Inflammation/Immunology
meso-Zeaxanthin accumulates in the central retina and forms macular pigment together with lutein and zeaxanthin, which has the function of light filtering. meso-Zeaxanthin can quench ROS and exert antioxidant function .

HY-W720042A

*(rac)-Zeaxanthin* dimethyl ether**	Biochemical Assay Reagents	Others
(rac)-Zeaxanthin dimethyl ether is the racemate of Zeaxanthin dimethyl ester. Zeaxanthin is a type of xanthophyll. (rac)-Zeaxanthin dimethyl ether has applications as pharmaceuticals and nutraceuticals and in the food industry .

HY-N18644

Calendula extract	Bacterial	Inflammation/Immunology Cancer
The main active ingredients of calendula extract are lutein and zeaxanthin. It has anti-aging, anti-inflammatory and antibacterial effects. It also has a certain moisturizing effect, thus can be used as a good functional cosmetics raw material.

*Zeaxanthin* 2 Publications Verification	Classification of Application Fields Erythrina melanacantha Taub. ex Harms Whitening Agent Endocrine diseases Plants Compositae Endogenous metabolite Food Research Other Terpenoids Immune System Disorder Microorganisms Terpenoids Disease markers Pigments Cosmetic Research Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
Zeaxanthin, a diet-obtained carotenoid, presents in the macula region of the eye. Zeaxanthin shows antioxidant effects .

Zeaxanthin dipalmitate Physalien	Structural Classification Classification of Application Fields Terpenoids Diterpenoids Solanaceae Plants Lycium chinense Miller Inflammation/Immunology Disease Research Fields Source Classification	Adiponectin Receptor P2X Receptor Autophagy
Zeaxanthin dipalmitate (Physalien) is a wolfberry-derived carotenoid, has anti-inflammatory and anti-oxidative stress effects. Zeaxanthin dipalmitate directly interact with p2X7 receptor (K_d=81.2 nM) and adiponectin receptor 1 (AdipoR1; K_d=533 nM) in a positive dose-dependent manner. Zeaxanthin dipalmitate restores mitochondrial autophagy functions suppressed by ethanol intoxication. Zeaxanthin dipalmitate can be used in the research of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP) .

Crocetin dialdehyde	Natural Products Crocus sativus Linn. Iridaceae Plants Source Classification	Drug Derivative
Crocetin dialdehyde is a non-volatile apocarotenoid obtained by the action of the plastidic enzyme CCD2 over the carotenoid zeaxanthin in saffron. Crocetin dialdehyde can be converted into Crocetin (HY-N2072) by aldehyde dehydrogenases (ALDHs). Crocetin dialdehyde has no effect on the liver in mice .

Violaxanthin	Structural Classification Natural Products Viola tricolor L. Violaceae Plants Source Classification	Photosystem II
Violaxanthin is a lipophilic epoxy carotenoid and a light energy scavenger with biological activities such as antioxidation and anti-inflammation. Violaxanthin exists in photosynthetic eukaryotes including higher plants and participates in the xanthophyll cycle. As a component of the xanthophyll cycle, violaxanthin can be synthesized from zeaxanthin under the catalysis of epoxidase and scavenge excess light energy in photosynthetic eukaryotes .

*(rac)-Zeaxanthin* dimethyl ether**	Natural Products Microorganisms Source Classification	Biochemical Assay Reagents
(rac)-Zeaxanthin dimethyl ether is the racemate of Zeaxanthin dimethyl ester. Zeaxanthin is a type of xanthophyll. (rac)-Zeaxanthin dimethyl ether has applications as pharmaceuticals and nutraceuticals and in the food industry .

Calendula extract	Structural Classification Extract	Bacterial
The main active ingredients of calendula extract are lutein and zeaxanthin. It has anti-aging, anti-inflammatory and antibacterial effects. It also has a certain moisturizing effect, thus can be used as a good functional cosmetics raw material.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Zeaxanthin

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