Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
cGKI
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "cGKI" in MCE Product Catalog:
Cat. No.: HY-108548
CAS No.: 185246-32-6
Synonyms: Rp-8-Bromo-PET-cGMPS
Target:
Research Areas:
Rp-8-Br-PET-cGMPS sodium (Rp-8-Bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis=35 and 30 nM). It less potently inhibits protein kinase A (Ki=11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50=25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki=1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.
Cat. No.: HY-RS11154
Target:
Research Areas:
PRKG1 Human Pre-designed siRNA Set A contains three designed siRNAs for PRKG1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-137378A
CAS No.: 144510-04-3
Target:
Research Areas:
8-Br-PET-cGMP is an agonist of cGMP-dependent protein kinase type I (cGKI). 8-Br-PET-cGMP promotes the dimerization of cGKI and activates its catalytic activity by binding to the regulatory domain of cGKI. 8-Br-PET-cGMP can be used to study the role of cGMP signaling pathways in cell growth, vasodilation, and smooth muscle cell function .
Cat. No.: HY-RS20087
Target:
Research Areas:
Prkg1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkg1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P71234
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRKG1; cGKI; Prev. PRKGR1B; Protein Kinase, CGMP-Dependent, Regulatory, Type I, Beta; Prev. PRKG1B; CGMP-Dependent Protein Kinase I; PKG1; CGMP-Dependent Protein Kinase; PKG; cGKI-Alpha; Protein Kinase, CGMP-Dependent, Type I; cGKI-BETA; CGMP-Dependent Pr
Species:
Human
Source:
HEK293
Cat. No.: HY-P702647
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: PRKG1; cGKI; Prev. PRKGR1B; Protein Kinase, CGMP-Dependent, Regulatory, Type I, Beta; Prev. PRKG1B; CGMP-Dependent Protein Kinase I; PKG1; CGMP-Dependent Protein Kinase; PKG; cGKI-Alpha; Protein Kinase, CGMP-Dependent, Type I; cGKI-BETA; CGMP-Dependent Pr
Species:
Human
Source:
Sf9 insect cells
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
