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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
43 Results for "
citrate synthase
" in MedChemExpress (MCE) Product Catalog:
Products (43)
43 Results for "citrate synthase" in MCE Product Catalog:
Target:
Research Areas:
Citrate synthase is responsible for catalyzing the first reaction of the citric acid cycle: the condensation of acetyl-CoA and oxaloacetate to form citrate. Citrate synthase is localized within eukaryotic cells in the mitochondrial matrix .
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Category:
Microorganisms Neurological Disease Anti-aging Amino acids Endogenous metabolite Disease Research Fields
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Research Areas:
Et-29 (NRD167) is a selective SIRT5 inhibitor. Et-29 increases the levels of total protein succinylation and citrate synthase succinylation in cells. Et-29 reduces serum CTX-I levels and blocks Ferroptosis by downregulating the SIRT5/ACSL4/LPCAT3/ALOX15 axis and restoring antioxidant defense. Et-29 decreases bone resorption and improves trabecular bone mass and microarchitecture. Et-29 is applicable for research related to osteoporosis and hepatocellular carcinoma .
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1 Cited Publications
Cat. No.: HY-N0473S9
CAS No.: 130551-49-4
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1 Cited Publications
Cat. No.: HY-N0473S8
CAS No.: 72963-27-0
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1 Cited Publications
Cat. No.: HY-N0473S4
CAS No.: 110622-46-3
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1 Cited Publications
Cat. No.: HY-Q51222
CAS No.: 100264-64-0
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ZINC110492 is a selective ligand of CS-ΔEx4 (a splicing isoform of citrate synthase (CS)). ZINC110492 does not bind to CS full-length (CS-FL). ZINC110492 inhibits colorectal cancer (CRC) cell growth in cells overexpressing CS-ΔEx4 with an IC50 of 7.840 µM. ZINC110492 significantly decreases both citrate and 2-hydroxyglutarate (2-HG) levels in the CS-ΔEx4-overexpressing SW1116 cells .
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Cat. No.: HY-N0473S14
CAS No.: 1226919-57-8
Cat. No.: HY-N0473S
CAS No.: 62595-14-6
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Research Areas:
Glutaryl coenzyme A lithium is an endogenous metabolite. Glutaryl coenzyme A lithium acts on the E2k subunit to inhibit KGDHc. It serves as a substrate for the reverse reaction of E2k and does not affect the E1k or E3 subunits of KGDHc. Glutaryl coenzyme A lithium exhibits weak inhibitory activity against citrate synthase. It can be used in research on glutaryl-CoA dehydrogenase deficiency (type I glutaric acidemia) .
Cat. No.: HY-N0473S1
CAS No.: 35424-81-8
Cat. No.: HY-N0473S2
CAS No.: 201595-63-3
Cat. No.: HY-N0473S13
CAS No.: 57746-15-3
Cat. No.: HY-N0473S3
CAS No.: 55443-60-2
Cat. No.: HY-N0473S15
CAS No.: 71939-39-4
Cat. No.: HY-N0473S10
CAS No.: 30811-19-9
Cat. No.: HY-N0473S5
CAS No.: 81201-90-3
Cat. No.: HY-N0473S7
CAS No.: 81201-89-0
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
