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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
copper-mediated umpolung arylation
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "copper-mediated umpolung arylation" in MCE Product Catalog:
1
Cat. No.: HY-W010320
CAS No.: 4940-11-8
Synonyms: 2-Ethyl-3-hydroxy-4H-pyran-4-one
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Ethyl maltol (2-Ethyl-3-hydroxy-4H-pyran-4-one) is an orally active and important food additive and flavor enhancer. Ethyl maltol is less toxic to rats and dogs. Ethyl maltol can enhance copper-mediated cytotoxicity and induce apoptosis in lung epithelial cells .
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Bromonitromethane is a halogenated nitromethane disinfection byproduct. Bromonitromethane does not induce morphological changes in lung cells, alter cell growth status, change the secretion levels of matrix metalloproteinases, or enhance the anchorage-independent growth ability of lung cells. Bromonitromethane can act as a bromine donor to participate in the bis (amidine)-catalyzed enantioselective aza-Henry addition reaction of N-(trimethylsilyl) imines, which is used in the synthesis of α-bromonitroalkane donors for umpolung amide synthesis (UmAS). Bromonitromethane can be used in bronchial and cancer research .
Cat. No.: HY-W007317
CAS No.: 578-66-5
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8-Aminoquinoline is a chelating ligand and intermediate. 8-Aminoquinoline assists metal-catalyzed direct C (sp 2)-H and unactivated C (sp 3)-H bond functionalization, copper-mediated C-H/C-H coupling, as well as copper/silver-catalyzed aryl C (sp 2)-H amination reactions. 8-Aminoquinoline forms cationic Pt (II) complexes with anti-tumor activity. 8-Aminoquinoline is used in research related to latent malaria, glioblastoma, pancreatic adenocarcinoma, adenocarcinoma and biphasic mesothelioma .
Cat. No.: HY-W017187
CAS No.: 3602-55-9
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2-tert-Butyl-1,4-benzoquinone is a food additive oxidant, an electrophilic metabolite of Butylated hydroxyanisole (HY-B1066), and an antibacterial agent. 2-tert-Butyl-1,4-benzoquinone reduces virulence factors, activates Nrf2, and induces S-arylation of its negative regulator Keap1. 2-tert-Butyl-1,4-benzoquinone induces HO-1. 2-tert-Butyl-1,4-benzoquinone exhibits quorum sensing inhibitory activity against Chromobacterium violaceum .
Cat. No.: HY-W039724
CAS No.: 492-22-8
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Thioxanthone is a powerful photocatalyst for organic reactions. Thioxanthone mediates energy transfer, single-electron transfer, and hydrogen atom transfer processes. As a photoredox catalyst, Thioxanthone is used in nickel-catalyzed self-coupling reactions of aryl halides, arylation reactions of H-phosphine oxides/H-phosphites, decarbonylation reactions of cyclopropenones, and reactions generating acyl radicals from aromatic aldehydes .
Cat. No.: HY-W054259
CAS No.: 69010-90-8
Synonyms: N,N'-Difurfuryloxamide; N1,N2-Bis(furan-2-ylmethyl)oxalamide
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Cat. No.: HY-W017512
CAS No.: 17496-14-9
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2-Methylindanone is a cyclic ketone compound. 2-Methylindanone is an important substrate for evaluating the effects of Pd and Ni in asymmetric α-arylation reactions. 2-Methylindanone can also be used as a drug intermediate .
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LDL-IN-2 (compound 3) is an antioxidant against copper mediated low-density lipoproteins (LDL) oxidation .
Cat. No.: HY-119265
CAS No.: 615264-62-5
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LDL-IN-4 (Compound 2) inhibits human acyl-CoA:cholesterol acyltransferase-1 and -2 activities. LDL-IN-4 inhibits copper-mediated low density lipoprotein (LDL) oxidation, with an IC50 of 3 μM. LDL-IN-4 has anti-atherosclerotic biological activity .
Cat. No.: HY-W010320S
Synonyms: 2-Ethyl-3-hydroxy-4H-pyran-4-one-d5
Cat. No.: HY-W010320R
CAS No.: 4940-11-8
Synonyms: 2-Ethyl-3-hydroxy-4H-pyran-4-one (Standard)
Research Areas:
Ethyl maltol (Standard) is the analytical standard of Ethyl maltol. This product is intended for research and analytical applications. Ethyl maltol (2-Ethyl-3-hydroxy-4H-pyran-4-one) is an orally active and important food additive and flavor enhancer. Ethyl maltol is less toxic to rats and dogs. Ethyl maltol can enhance copper-mediated cytotoxicity and induce apoptosis in lung epithelial cells .
Cat. No.: HY-173477
CAS No.: 2446965-04-2
JR5-26B is an orally active apoptosis inducer. JR5-26B induces cell death through copper-mediated apoptosis and necroptosis. JR5-26B exhibits antiproliferative activity on MIA PaCa-2, PANC-1, PAN02, SU.86.86, and KPC-2 cells with IC50s of 0.6, 4.4, 8.0, 1.1, and 3.4μM, respectively .
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LDL-IN-1 (Compound 1) is an antioxidant, and is active against copper mediated LDL oxidation (IC50 = 52 μM). LDL-IN-1 is also an Acyl-CoA:cholesterol acyltransferase-1 and -2 (ACAT-1/2) inhibitor, with IC50s of 60 μM. LDL-IN-1 can be used for anti-atherosclerotic research .
Cat. No.: HY-182944
CAS No.: 1265900-99-9
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GATT-44 is a blood-brain barrier-permeable, selective GABA transporter 1 (GAT-1) ligand with an IC50 of 126 nM. GATT-44 shows selectivity for GAT-2, GAT-3 and BGT-1 subtypes, and undergoes copper-mediated 18F-radiofluorination. The radiolabeled GATT-44 ([ 18F]GATT-44) exhibits brain uptake, metabolic stability and high GAT-1 binding specificity in non-human primates. GATT-44 is applicable for research on neurodegenerative and neuropsychiatric diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
