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cycloartane-type triterpene glycoside

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By Targets:	Autophagy (2) Drug Derivative (1) HIF/HIF Prolyl-Hydroxylase (2) Interleukin Related (2) NF-κB (2) Parasite (1) Reference Standards (2) SOD (2)
By Research Areas:	Cancer (3) Endocrinology (2) Infection (1) Inflammation/Immunology (2) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0433

Astragaloside II 1 Publications Verification Astrasieversianin VIII	Autophagy Interleukin Related HIF/HIF Prolyl-Hydroxylase SOD NF-κB	Inflammation/Immunology Endocrinology Cancer
Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, IL-1β), HIF-α, p-p65, p-IκB and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis .

HY-N8715

Cimilactone A	Others	Others
Cimilactone A is a cycloartane-type **triterpene glycoside*. Cimilactone A can be isolated from the rhizomes of Cimicifuga foetida* .

HY-N18320

Astrachrysoside A	Drug Derivative	Others
Astrachrysoside A is a cycloartane-type triterpene glycoside found in Astragalus wiedemannianus .

HY-N19709

Abrusoside E	Others	Others
Abrusoside E is a cycloartane-type triterpene glycoside found in Abrus precatorius leaves. Abrusoside E is only arginally sweet .

HY-N1985

Acetylastragaloside I	Parasite	Infection
Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC₅₀ values of 9.5 and 5.0 μg/mL for *T. brucei rhodesiense* and *T. cruzi*, respectively. Acetylastragaloside I can be used for the research of trypanosome infection .

HY-N5052R

Asiaticoside B (Standard)	Reference Standards	Neurological Disease Cancer
Asiaticoside B (Standard) is the analytical standard of Asiaticoside B (HY-N5052). This product is intended for research and analytical applications. Asiaticoside B is a 9,19-cycloartane-type triterpene glycoside. Asiaticoside B induces cytotoxicity in liver cancer and breast cancer cells. Asiaticoside B alleviates 6-OHDA-induced neuronal cell damage. Asiaticoside B can be used in studies related to liver cancer, breast cancer and Parkinson's disease .

HY-N0433R

Astragaloside II (Standard) Astrasieversianin VIII (Standard)	Reference Standards Autophagy Interleukin Related HIF/HIF Prolyl-Hydroxylase SOD NF-κB	Inflammation/Immunology Endocrinology Cancer
Astragaloside II (Standard) is the analytical standard of Astragaloside II (HY-N0433). This product is intended for research and analytical applications. Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, IL-1β), HIF-α, p-p65, p-IκB and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis .

Astragaloside II 1 Publications Verification Astrasieversianin VIII	Triterpenes Classification of Application Fields Leguminosae Terpenoids Other Diseases Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields Source Classification	Autophagy Interleukin Related HIF/HIF Prolyl-Hydroxylase SOD NF-κB
Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, IL-1β), HIF-α, p-p65, p-IκB and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis .

Cimilactone A	Triterpenes Terpenoids Ranunculaceae Plants Cimicifuga foetida Linn. Source Classification	Others
Cimilactone A is a cycloartane-type **triterpene glycoside*. Cimilactone A can be isolated from the rhizomes of Cimicifuga foetida* .

Astrachrysoside A	Triterpenes Structural Classification Leguminosae Terpenoids Plants Astragalus membranaceus (Fisch.) Bunge Source Classification	Drug Derivative
Astrachrysoside A is a cycloartane-type triterpene glycoside found in Astragalus wiedemannianus .

Abrusoside E	Structural Classification Polysaccharides Leguminosae Abrus precatorius Linn. Plants Saccharides Source Classification	Others
Abrusoside E is a cycloartane-type triterpene glycoside found in Abrus precatorius leaves. Abrusoside E is only arginally sweet .

Acetylastragaloside I	Triterpenes Structural Classification Tetracyclic Triterpenoids Leguminosae Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants	Parasite
Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC₅₀ values of 9.5 and 5.0 μg/mL for *T. brucei rhodesiense* and *T. cruzi*, respectively. Acetylastragaloside I can be used for the research of trypanosome infection .

Asiaticoside B (Standard)	Triterpenes Structural Classification Terpenoids Centella asiatica (L.) Urb. Umbelliferae Plants Source Classification	Reference Standards
Asiaticoside B (Standard) is the analytical standard of Asiaticoside B (HY-N5052). This product is intended for research and analytical applications. Asiaticoside B is a 9,19-cycloartane-type triterpene glycoside. Asiaticoside B induces cytotoxicity in liver cancer and breast cancer cells. Asiaticoside B alleviates 6-OHDA-induced neuronal cell damage. Asiaticoside B can be used in studies related to liver cancer, breast cancer and Parkinson's disease .

Astragaloside II (Standard) Astrasieversianin VIII (Standard)	Triterpenes Structural Classification Leguminosae Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Source Classification	Reference Standards Autophagy Interleukin Related HIF/HIF Prolyl-Hydroxylase SOD NF-κB
Astragaloside II (Standard) is the analytical standard of Astragaloside II (HY-N0433). This product is intended for research and analytical applications. Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, IL-1β), HIF-α, p-p65, p-IκB and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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cycloartane-type triterpene glycoside

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