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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
dTAGV1
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "dTAGV1" in MCE Product Catalog:
6
6 Publications Verification
dTAGV-1 TFA is a selective FKBP12 F36V PORTAC degrader. dTAGV-1 TFA induces rapid degradation of FKBP12 F36V-tagged oncogenic fusion proteins, triggering collapse of downstream cellular signaling pathways, reduced proliferative capacity of cancer cells, and decreased levels of target proteins. dTAGV-1 TFA is applicable to functional validation studies of cancer and undegradable oncoproteins [1] .
6
6 Publications Verification
dTAGV-1 hydrochloride is a selective FKBP12 F36V PORTAC degrader. dTAGV-1 hydrochloride induces rapid degradation of FKBP12 F36V-tagged oncogenic fusion proteins, triggering collapse of downstream cellular signaling pathways, reduced proliferative capacity of cancer cells, and decreased levels of target proteins. dTAGV-1 hydrochloride is applicable to functional validation studies of cancer and undegradable oncoproteins [1] .
6
6 Publications Verification
Cat. No.: HY-145514D
CAS No.: 2451573-86-5
dTAGV-1 is a selective FKBP12 F36V PORTAC degrader. dTAGV-1 induces rapid degradation of FKBP12 F36V-tagged oncogenic fusion proteins, triggering collapse of downstream cellular signaling pathways, reduced proliferative capacity of cancer cells, and decreased levels of target proteins. dTAGV-1 is applicable to functional validation studies of cancer and undegradable oncoproteins [1] .
Target:
Research Areas:
dTAGV-1-NEG is an inactive FKBP12 F36V PROTAC degrader, the diastereomer of dTAGV-1 (HY-145514D), and a heterobifunctional negative control molecule. dTAGV-1-NEG does not degrade any protein [1].
Cat. No.: HY-147099
Purity: 97.8%
dTAG-47-NEG is an inactive bifunctional negative control PROTAC and also the diastereomer of dTAGV-1 (HY-145514D). dTAG-47-NEG does not reduce the level of BCL11A-FKBP12 F36V, nor does it induce the degradation of BCL11A-FKBP12 F36V, proteins tagged with FKBP12 F36V, wild-type FKBP12, FKBP12 F36V-KRAS G12V or FKBP12 F36V-EWS/FLI. dTAG-47-NEG exerts no antiproliferative effect in cancer cells [1] .
Cat. No.: HY-145514B
Target:
Research Areas:
dTAGV-1-NEG TFA is an inactive FKBP12 F36V PROTAC degrader, the diastereomer of dTAGV-1 (HY-145514D), and a heterobifunctional negative control molecule. dTAGV-1-NEG TFA does not degrade any protein [1].
Cat. No.: HY-173628A
CAS No.: 2451573-91-2
Research Areas:
(S,R,S)-AHPC-Me-N-Boc-7-aminoheptanoic acid is a conjugate of an E3 ligase ligand and a linker, which can be used for the synthesis of PROTAC dTAGV-1 TFA (HY-145514) [1].
Cat. No.: HY-173627A
CAS No.: 2451573-93-4
Target:
Research Areas:
(R,S,S)-VH032-Me TFA is an E3 ligase Ligand and can be used for synthesis of dTAGV-1 hydrochloride (HY-145514C) [1].
Cat. No.: HY-173628B
Research Areas:
(R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid TFA is a conjugate of an E3 ubiquitin ligase ligand (HY-112078) and a linker (HY-W012001). (R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid TFA can be used as an intermediate in the synthesis of dTAGV-1 hydrochloride (HY-145514C) [1].
Cat. No.: HY-173627
CAS No.: 1948273-05-9
Target:
Research Areas:
(R,S,S)-VH032-Me is a ligand for E3 ubiquitin ligase. (R,S,S)-VH032-Me can be connected to the ligand for protein by a linker to form dTAGV-1-NEG (HY-145514A). PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins [1].
Cat. No.: HY-173628
Research Areas:
(R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid is a E3 Ligase Ligand-Linker Conjugate, consisting of N-Boc-7-aminoheptanoic acid (HY-W012001) and the corresponding Linker. (R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid can be used for the synthesis of dTAGV-1-NEG (HY-145514A) [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
