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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1183 Results for "
differentiate
" in MedChemExpress (MCE) Product Catalog:
Products (1183)
1183 Results for "differentiate" in MCE Product Catalog:
825
825 Publications Verification
Cat. No.: HY-18739
CAS No.: 16561-29-8
Synonyms: PMA; TPA; Phorbol myristate acetate
224
224 Cited Publications
Synonyms: Coleonol; Colforsin; HL 362
Category:
Labiatae Terpenoids Metabolic Disease Diterpenoids Plants Disease Research Fields Inflammation/Immunology Endocrinology Pueraria montana (Lour.) Merr.
Target:
201
201 Cited Publications
XAV-939 is a Tankyrase inhibitor. XAV-939 has inhibitory activity for TNKS1 and TNKS2 with IC50 values of 5 nM and 2 nM, respectively. XAV-939 also is an enhancer of osteoblastic differentiation of hMSCs. XAV-939 can be used for the research of conditions associated with activated Wnt signaling, such as cancer, fibrotic diseases and conditions associated with low bone formation .
169
Research Areas:
DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment .
146
146 Cited Publications
Synonyms: Vitamin A acid; all-trans-Retinoic acid; ATRA
146
146 Cited Publications
Synonyms: Vitamin A acid (Standard); all-trans-Retinoic acid (Standard); ATRA (Standard)
137
137 Cited Publications
Synonyms: β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol
137
137 Cited Publications
Synonyms: β-Estradiol (Standard); E2 (Standard); 17β-Estradiol (Standard); 17β-Oestradiol (Standard)
136
136 Cited Publications
Cat. No.: HY-B0141C
CAS No.: 35380-71-3
Synonyms: β-Estradiol hemihydrate; 17β-Estradiol hemihydrate; 17β-Oestradiol hemihydrate
Category:
111
111 Cited Publications
Target:
Research Areas:
SIS3 is a potent and selective inhibitor of Smad3 with an IC50 of 3 μM for Smad3 phosphorylation. SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1 .
111
111 Cited Publications
Target:
Research Areas:
SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2 .
98
98 Cited Publications
Synonyms: EPZ-6438; E-7438
Target:
Research Areas:
Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. Tazemetostat inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC50 of 4 nM. Tazemetostat also inhibits EZH1 with an IC50 of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells .
34
34 Cited Publications
Target:
Research Areas:
TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway . TJ-M2010-5 can be used for the research of myocardial ischemia/reperfusion injury (MIRI) .
33
Target:
Research Areas:
Kartogenin (KGN) is an inducer of chondrogenic tissue formation (EC50: 100 nM). Kartogenin induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research .
31
31 Cited Publications
Target:
31
31 Cited Publications
Cat. No.: HY-D0886
CAS No.: 13408-09-8
Category:
Natural Products Neurological Disease Endogenous metabolite Disease Research Fields Cancer
Target:
30
30 Cited Publications
Synonyms: L-Glutamic acid 5-amide (Standard)
28
27
27 Cited Publications
Synonyms: Cholecalciferol; Colecalciferol
26
26 Cited Publications
Synonyms: Zoledronate; CGP 42446; CGP42446A; ZOL 446
Research Areas:
Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
