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Results for "

dual EGFR/COX-2 inhibitors

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

1

Natural
Products

Targets Recommended:
Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-178440
    EGFR/COX-2-IN-2

    		EGFR COX Apoptosis Inflammation/Immunology Cancer
    EGFR/COX-2-IN-2 (Compound 10a) is a dual inhibitor targeting epidermal growth factor receptor (EGFR) (IC50= 6.0 μM) and cyclooxygenase-2 (COX-2) (IC50=50 μM). EGFR/COX-2-IN-2 induces S-phase cell cycle arrest and apoptosis. EGFR/COX-2-IN-2 is promising for research of cancers and inflammation-related diseases .
    EGFR/COX-2-IN-2
  • HY-165394
    Melafolone

    		COX EGFR PD-1/PD-L1 PI3K Akt Inflammation/Immunology Cancer
    Melafolone is a potent dual COX-2/EGFR inhibitor with IC50s of 13.2 μM (COX-2) and 17.4 μM (EGFR). Melafolone enhances the effect of anti-PD-1 through vascular normalization and PD-L1 downregulation via the PI3K/Akt pathway in Lewis lung carcinoma (LLC) and CMT167 models. Melafolone can be used for lung cancer research .
    Melafolone
  • HY-181056
    EGFR/COX-2-IN-3

    		EGFR COX Neurological Disease Cancer
    EGFR/COX-2-IN-3 is a selective EGFR/COX-2 dual inhibitor with IC50 values of 0.098 μM and 0.05 μM, respectively. EGFR/COX-2-IN-3 is predicted to have oral activity and blood-brain barrier permeability. EGFR/COX-2-IN-3 exhibits both potent analgesic activity and anti-glioblastoma effects. EGFR/COX-2-IN-3 can be used in the research of tumors such as glioblastoma .
    EGFR/COX-2-IN-3

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