2. Search Result
Search Result
Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
Results for "

ferroptotic cell death

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

1

Fluorescent Dyes

2

Natural
Products

2

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100218A
    RSL3
    Maximum Cited Publications
    514 Publications Verification

    (1S,3R)-RSL3

    		 p62 Glutathione Peroxidase Ferroptosis Reactive Oxygen Species (ROS) Cancer
    RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .
    RSL3
  • HY-12726
    Liproxstatin-1
    230+ Cited Publications

    		 Ferroptosis Cancer
    Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM) .
    Liproxstatin-1
  • HY-12726A
    Liproxstatin-1 hydrochloride
    230+ Cited Publications

    		 Ferroptosis Cancer
    Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM) .
    Liproxstatin-1 hydrochloride
  • HY-175327
    LIBX-A402

    		ACSL Family Ferroptosis Neurological Disease Cancer
    LIBX-A402 is a selective, ATP-dependent inhibitor of ACSL4 (hACSL4, IC50=0.33 μM, Kd=3.3 μM) and an inhibitor of ferroptosis. LIBX-A402 targets the fatty acid-binding pocket of ACSL4 and prevents cells from undergoing ferroptosis. LIBX-A402 can be used in the research of cancer and Parkinson's disease .
    LIBX-A402
  • HY-115701
    1-Stearoyl-2-15(S)-Hpete-Sn-Glycero-3-Pe

    1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine; 15(S)-HpETE-SAPE; 15(S)-hydroperoxyeicostetraenoic acid-SAPE

    		 Ferroptosis Inflammation/Immunology
    1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-Pe (SAPE) by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.
    1-Stearoyl-2-15(S)-Hpete-Sn-Glycero-3-Pe
  • HY-N8198
    Ardisiacrispin B

    		Apoptosis Ferroptosis Cancer
    Ardisiacrispin B displays cytotoxic effects in multi-factorial agent resistant cancer cells via ferroptotic and apoptotic cell death .
    Ardisiacrispin B
  • HY-139826
    CuATSP

    		Ferroptosis Neurological Disease
    CuATSP, a potent inhibitor of ferroptotic cell death, is almost 20-fold more potent than CuATSM.
    CuATSP
  • HY-100218C
    (1R,3R)-RSL3
    3 Publications Verification

    		 Drug Isomer Ferroptosis Cancer
    (1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .
    (1R,3R)-RSL3
  • HY-W009300
    4-Hydroxyestrone
    1 Publications Verification

    4-OHE1

    		 Endogenous Metabolite Estrogen Receptor/ERR Sirtuin MDM-2/p53 PDI Ferroptosis Reactive Oxygen Species (ROS) Neurological Disease Metabolic Disease Cancer
    4-Hydroxyestrone (4-OHE1) is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease .
    4-Hydroxyestrone
  • HY-12726S1
    Liproxstatin-1-15N

    		Isotope-Labeled Compounds Cancer
    Liproxstatin-1- 15N is the 15N labled Liproxstatin-1 (HY-12726). Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM) .
    Liproxstatin-1-15N
  • HY-163287
    QPy-TPA

    		Fluorescent Dye Others
    QPy-TPA is a lipopjilc probes, which induces non-ferroptotic cell death and lipid dynamic regularion in B16 and HepG2 cells upon light irradiation. QPy-TPA reveals a maximum absorption wavelength of 400 nm and a maximum emission wavelength of 590 nm .
    QPy-TPA
  • HY-12726S
    Liproxstatin-1-13C6

    		Isotope-Labeled Compounds Cancer
    Liproxstatin-1- 13C6 is the 13C labled Liproxstatin-1 (HY-12726). Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM) .
    Liproxstatin-1-13C6
  • HY-100218AR
    RSL3 (Standard)

    (1S,3R)-RSL3 (Standard)

    		 p62 Glutathione Peroxidase Reference Standards Ferroptosis Reactive Oxygen Species (ROS) Cancer
    RSL3 (Standard) is the analytical standard of RSL3 (HY-100218A). This product is intended for research and analytical applications. RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .
    RSL3 (Standard)
  • HY-100218CR
    (1R,3R)-RSL3 (Standard)

    		Drug Isomer Ferroptosis Reference Standards Cancer
    (1R,3R)-RSL3 (Standard) is the analytical standard of (1R,3R)-RSL3 (HY-100218C). This product is intended for research and analytical applications. (1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .
    (1R,3R)-RSL3 (Standard)

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: