Search Result

Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

fibroblast cell lines

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Amino Acid Derivatives (1) Apoptosis (3) Bacterial (1) Biochemical Assay Reagents (3) Caspase (1) Cholinesterase (ChE) (2) DNA/RNA Synthesis (1) Drug Intermediate (1) EGFR (2) Environmental Pollutants (1) Interleukin Related (1) Lactate Dehydrogenase (1) mTOR (1) P-glycoprotein (1) Phospholipase (1) PI3K (1) Pim (1) Ras (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) RET (1) TNF Receptor (1)
By Research Areas:	Cancer (13) Infection (1) Inflammation/Immunology (2) Neurological Disease (3)

By Targets:

5-HT Receptor (1)

Amino Acid Derivatives (1)

Apoptosis (3)

Bacterial (1)

Biochemical Assay Reagents (3)

Caspase (1)

Cholinesterase (ChE) (2)

DNA/RNA Synthesis (1)

Drug Intermediate (1)

EGFR (2)

Environmental Pollutants (1)

Interleukin Related (1)

Lactate Dehydrogenase (1)

mTOR (1)

P-glycoprotein (1)

Phospholipase (1)

PI3K (1)

Pim (1)

Ras (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (1)

RET (1)

TNF Receptor (1)

By Research Areas:

Cancer (13)

Infection (1)

Inflammation/Immunology (2)

Neurological Disease (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Targets Recommended: FAP FGFR Programmed Cell Death 4 (PDCD4) Itk TOPK NAMPT ALCAM/CD166 GDNF Receptor BCL6 Tim3 VISTA BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0850

Polyvinyl alcohol (Mw 146000-186000, 99+% hydrolyzed) 3 Publications Verification	Environmental Pollutants Biochemical Assay Reagents	Neurological Disease
Polyvinyl alcohol (Mw 146000-186000, 99+% hydrolyzed) is a non-biodegradable, hydrophilic, odorless biomedical polymer with cell adhesion/proliferation inhibition, peripheral nerve regeneration induction, dissolution enhancement, and non-toxic, biocompatible properties .

HY-176798

NCI-006	Lactate Dehydrogenase Reactive Oxygen Species (ROS) Apoptosis	Cancer
NCI-006 is an orally active lactate dehydrogenase (LDH) inhibitor (LDHA IC₅₀ = 0.06 μM; LDHB IC₅₀ = 0.03 μM). NCI-006 inhibits intratumoral LDH activity, lactate production, and tumor growth in a mouse pancreatic cancer model. NCI-006 inhibits glycolysis and induces apoptosis in vitro. NCI-006 enhances the radiosensitivity of glycolytic tumor cell lines while sparing non-glycolytic/normal cells (1522, skin fibroblasts) in combination with ionizing radiation (IR). NCI-006 exhibits synergistic antitumor effects in combination with IACS-010759 (HY-112037) against colorectal and gastric cancers. NCI-006 targets glycolysis by inhibiting lactate dehydrogenase impairs tumor growth in an Ewing sarcoma model .

HY-W001939

4-Acetylbenzoic acid	Biochemical Assay Reagents	Cancer
4-Acetylbenzoic acid is a Zn(II) complex. 4-Acetylbenzoic acid is a derivative of benzoic acid that is commonly used in chemical synthesis. 4-Acetylbenzoic acid has an IC₅₀ of 331.3 μM in murine L929 fibroblasts and an IC₅₀ of 176 μM in metastatic melanoma B16 F10 cell lines .

HY-147802

EGFR-IN-59	EGFR Apoptosis	Cancer
EGFR-IN-59 (Compound 8c) is a EGFR inhibitor (IC₅₀=190 nM) and apoptosis inducer. EGFR-IN-59 exhibits cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) with IC₅₀s of 8.62 and 52.6 µM, respectively. EGFR-IN-59 can be used for the research of various cancers such as non-small cell lung cancer (NSCLC), head and neck cancer, breast cancer and colorectal cancer .

HY-157404

Pim-1/2 kinase inhibitor 2	Pim	Cancer
Pim-1/2 kinase inhibitor 2 (compound 5b) is a competitive PIM-1 and PIM-2 kinase inhibitor with IC₅₀s of 1.31 μM and 0.67 μM, respectively. Pim-1/2 kinase inhibitor 2 shows in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer activity against myeloid leukaemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2) cancer cell lines .

HY-120621

BMS-229724	Phospholipase	Inflammation/Immunology
BMS-229724 is an orally active and tight-binding cytosolic phospholipase A₂ (cPLA₂) inhibitor with an IC₅₀ of 2.8 μM. BMS-229724 can inhibit the production of arachidonic acid and eicosanoids in U937 cells, neutrophils, platelets, and other cells. BMS-229724 has anti-inflammatory activity and can be used in the research of diseases such as skin inflammation .

HY-W773183

Methyl betulonate Betulonic acid methyl ester; Methyl 3-oxolup-20(29)-en-28-oate	Drug Intermediate	Cancer
Methyl betulonate (Betulonic acid methyl ester) is a triterpenoid. Methyl betulonate inhibits cell growth of eight tumor (including resistant) and two normal fibroblast cell lines with the IC_50s >50.0 μM .

HY-123464

RBC10	Ras	Cancer
RBC10 is an anti-cancer agent. RBC10 inhibits the binding of Ral to its effector RALBP1. RBC10 also inhibits Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines .

HY-173367

Anticancer agent 271	EGFR PI3K mTOR	Cancer
Anticancer agent 271 (compound 5C) has antiproliferative activity against lung (A549), colon (Caco-2) cancer cell lines, and human lung fibroblast (WI38) with an IC₅₀ value of 9.18 μM on A549 cells. Anticancer agent 271 downregulates PI3K and mTOR gene expression that can be used for cancer research .

HY-W001939R

4-Acetylbenzoic acid (Standard)	Biochemical Assay Reagents Reference Standards	Cancer
4-Acetylbenzoic acid (Standard) is the analytical standard of 4-Acetylbenzoic acid. This product is intended for research and analytical applications. 4-Acetylbenzoic acid is a Zn(II) complex. 4-Acetylbenzoic acid is a derivative of benzoic acid that is commonly used in chemical synthesis. 4-Acetylbenzoic acid has an IC₅₀ of 331.3 μM in murine L929 fibroblasts and an IC₅₀ of 176 μM in metastatic melanoma B16 F10 cell lines .

HY-136727A

Ac-LEVD-CHO TFA	Caspase Apoptosis	Cancer
Ac-LEVD-CHO (TFA) is an inhibitor of caspase-4. Ac-LEVD-CHO (TFA) can inhibit the expression and secretion of IL-1α expression as well as the activation of caspase-4 induced by the T. denticola periodontal pathogen surface protein Td92 in human gingival fibroblasts. Ac-LEVD-CHO (TFA) can also reduce the apoptosis due to the expression of the dominant negative adenoviral RNA-dependent protein kinase in A549 and PC3 cancer cell lines .

HY-164482

HG-6-63-01	RET	Cancer
HG-6-63-01 is a type II RET tyrosine kinase inhibitor (TKI). HG-6-63-01 also inhibits REarranged during Transfection (RET) kinase and signaling in human thyroid cancer cell lines carrying oncogenic RET alleles. HG-6-63-01 impairs phosphorylation and signalling of RET oncogenic mutants. HG-6-63-01 blunts proliferation of RET/C634R and RET/M918T-transformed fibroblasts and of RET mutant thyroid cancer cells, which is promising for research of cancers harboring oncogenic activation of RET .

HY-185347

AChE-IN-114	Cholinesterase (ChE)	Neurological Disease
AChE-IN-114 is a selective AChE inhibitor and shows weak inhibitory activity for BChE. AChE-IN-114 can be used for the research of alzheimer’s disease .

HY-W053641

(E)-2-Nitrocinnamic acid	Cholinesterase (ChE)	Neurological Disease
(E)-2-Nitrocinnamic acid (Compound 1k) is an Acetylcholinesterase inhibitor. (E)-2-Nitrocinnamic acid is applicable to research related to Alzheimer's disease .

HY-W750980

β-Bisabolol	TNF Receptor Interleukin Related	Inflammation/Immunology
β-Bisabolol is a potent anti-inflammatory agent that can be found in cotton gin trash. β-Bisabolol inhibits the production of nitric oxide (NO), pGE₂, TNF-α, IL-6, and IL-8 in LPS (HY-D1056)-stimulated macrophages and fibroblast cells. β-Bisabolol can be used for the research on inflammatory conditions .

HY-181269

InhA-IN-11	Bacterial	Infection
InhA-IN-11 is a Mycobacterium tuberculosis InhA inhibitor with an IC₅₀ of 0.36 μM. InhA-IN-11 exhibits activity against Mycobacterium tuberculosis, disrupts pre-formed Mycobacterium tuberculosis biofilms, and reduces bacterial viability within biofilms. InhA-IN-11 is applicable for the research of tuberculosis .

HY-181252

P-gp-IN-35	P-glycoprotein	Cancer
P-gp-IN-35 is a P-glycoprotein (P-gp) inhibitor. P-gp-IN-35 exhibits cytotoxicity against sensitive breast cancer and colorectal cancer cells, and can reverse multidrug resistance in breast cancer cells with P-gp overexpression. P-gp-IN-35 can be used in research related to multidrug-resistant breast cancer and colon cancer .

HY-182285A

FOXM1-IN-4 hydrochloride	5-HT Receptor DNA/RNA Synthesis	Cancer
FOXM1-IN-4 hydrochloride is a selective 5-HT₇ receptor inhibitor with a K_i of 92 nM. FOXM1-IN-4 hydrochloride blocks 5-HT₇ receptor signaling to reduce FOXM1, p-FOXM1, cyclin B1, and cdc25B levels. FOXM1-IN-4 hydrochloride acts as an antiproliferative, clonogenic inhibitor, and cell cycle inhibitor that induces G₂/M arrest, reduces G₀/G₁ population. FOXM1-IN-4 hydrochloride can be used for the research of triple-negative breast cancer .

HY-186120A

N-(Aminoiminomethyl)-N-methyl-L-alanine	Amino Acid Derivatives	Cancer
N-(Aminoiminomethyl)-N-methyl-L-alanine is an Amino acid analog. N-(Aminoiminomethyl)-N-methyl-L-alanine can be used in cancer-related research .

Cat. No.	Product Name	Type

HY-Y0850

Polyvinyl alcohol (Mw 146000-186000, 99+% hydrolyzed) 3 Publications Verification	Biochemical Assay Reagents
Polyvinyl alcohol (Mw 146000-186000, 99+% hydrolyzed) is a non-biodegradable, hydrophilic, odorless biomedical polymer with cell adhesion/proliferation inhibition, peripheral nerve regeneration induction, dissolution enhancement, and non-toxic, biocompatible properties .

HY-W001939

4-Acetylbenzoic acid	Biochemical Assay Reagents
4-Acetylbenzoic acid is a Zn(II) complex. 4-Acetylbenzoic acid is a derivative of benzoic acid that is commonly used in chemical synthesis. 4-Acetylbenzoic acid has an IC₅₀ of 331.3 μM in murine L929 fibroblasts and an IC₅₀ of 176 μM in metastatic melanoma B16 F10 cell lines .

HY-W001939R

4-Acetylbenzoic acid (Standard)	Biochemical Assay Reagents
4-Acetylbenzoic acid (Standard) is the analytical standard of 4-Acetylbenzoic acid. This product is intended for research and analytical applications. 4-Acetylbenzoic acid is a Zn(II) complex. 4-Acetylbenzoic acid is a derivative of benzoic acid that is commonly used in chemical synthesis. 4-Acetylbenzoic acid has an IC₅₀ of 331.3 μM in murine L929 fibroblasts and an IC₅₀ of 176 μM in metastatic melanoma B16 F10 cell lines .

4-Acetylbenzoic acid (Standard)

Biochemical Assay Reagents

4-Acetylbenzoic acid (Standard) is the analytical standard of 4-Acetylbenzoic acid. This product is intended for research and analytical applications. 4-Acetylbenzoic acid is a Zn(II) complex. 4-Acetylbenzoic acid is a derivative of benzoic acid that is commonly used in chemical synthesis. 4-Acetylbenzoic acid has an IC₅₀ of 331.3 μM in murine L929 fibroblasts and an IC₅₀ of 176 μM in metastatic melanoma B16 F10 cell lines .

Cat. No.	Product Name	Target	Research Area

HY-136727A

Ac-LEVD-CHO TFA	Caspase Apoptosis	Cancer
Ac-LEVD-CHO (TFA) is an inhibitor of caspase-4. Ac-LEVD-CHO (TFA) can inhibit the expression and secretion of IL-1α expression as well as the activation of caspase-4 induced by the T. denticola periodontal pathogen surface protein Td92 in human gingival fibroblasts. Ac-LEVD-CHO (TFA) can also reduce the apoptosis due to the expression of the dominant negative adenoviral RNA-dependent protein kinase in A549 and PC3 cancer cell lines .

Cat. No.	Product Name

HY-K3001

DMEM (High Glucose, L-Glutamine, Pyruvate, Phenol Red, no HEPES) 5+ Cited Publications
DMEM (Dulbecco's Modified Eagle Medium) is a widely used basal medium for supporting the growth of many different mammalian cells. Cell lines successfully cultured in DMEM include Hela, 293, Cos-7, and PC-12, as well as primary fibroblasts, neurons, glial cells, HUVECs, and smooth muscle cells. The 500 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

DMEM (High Glucose, L-Glutamine, Pyruvate, Phenol Red, no HEPES)

5+ Cited Publications

DMEM (Dulbecco's Modified Eagle Medium) is a widely used basal medium for supporting the growth of many different mammalian cells. Cell lines successfully cultured in DMEM include Hela, 293, Cos-7, and PC-12, as well as primary fibroblasts, neurons, glial cells, HUVECs, and smooth muscle cells. The 500 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

HY-K3003

DMEM (Low Glucose, L-Glutamine, Pyruvate, Phenol Red, no HEPES)
DMEM (Dulbecco's Modified Eagle Medium) is a widely used basal medium for supporting the growth of many different mammalian cells. Cell lines successfully cultured in DMEM include Hela, 293, Cos-7, and PC-12, as well as primary fibroblasts, neurons, glial cells, HUVECs, and smooth muscle cells, etc. The 500 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

DMEM (Low Glucose, L-Glutamine, Pyruvate, Phenol Red, no HEPES)

DMEM (Dulbecco's Modified Eagle Medium) is a widely used basal medium for supporting the growth of many different mammalian cells. Cell lines successfully cultured in DMEM include Hela, 293, Cos-7, and PC-12, as well as primary fibroblasts, neurons, glial cells, HUVECs, and smooth muscle cells, etc. The 500 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

β-Bisabolol	Structural Classification Natural Products Machilus zuihoensis Hayata Plants Lauraceae Source Classification	TNF Receptor Interleukin Related
β-Bisabolol is a potent anti-inflammatory agent that can be found in cotton gin trash. β-Bisabolol inhibits the production of nitric oxide (NO), pGE₂, TNF-α, IL-6, and IL-8 in LPS (HY-D1056)-stimulated macrophages and fibroblast cells. β-Bisabolol can be used for the research on inflammatory conditions .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.

fibroblast cell lines

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

MCE Kits

NaturalProducts

Natural
Products