Results for "

high-affinity IL-2 receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (5) Apoptosis (1) Fluorescent Dye (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (5)

Inhibitors & Agonists

Fluorescent Dyes

Inhibitory Antibodies

Recombinant Proteins

Targets Recommended: Itk Interleukin Related IRAK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108738

Daclizumab Ro 24-7375	Interleukin Related Apoptosis	Inflammation/Immunology Cancer
Daclizumab (Ro 24-7375) is a humanized, monoclonal antibody that blocks CD25 (α-subunit of the high-affinity interleukin-2 receptor (IL-2R-HA)). Daclizumab inhibits effector T cell activation, regulatory T cell (Treg) expansion and survival, and activation-induced T-cell apoptosis. Daclizumab increases *IL-2* bioavailability to bind to the intermediate-affinity *IL-2R* (IL-2R-IA), driving the expansion of anti-inflammatory CD56bright natural killer (NK) cells. Daclizumab can be used for multiple sclerosis and cancer research .

HY-119424

SP4206	Interleukin Related	Inflammation/Immunology
SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 binds with high affinity (K_d=70 nM) to *IL-2* and blocks binding to its natural receptor IL-2Rα (K_d=10 nM) .

HY-P990736

Efercoleukin alfa	Interleukin Related	Inflammation/Immunology
Efercoleukin alfa is a recombinant fusion protein comprising an IL-2 fused to a human IgG1 Fc. Efercoleukin alfa binds the high-affinity IL-2 receptor alpha chain (CD25) .

HY-P991270

MT204	Interleukin Related	Inflammation/Immunology
MT204 is a humanized IgG1 antibody inhibitor targeting IL-2 of human and rhesus monkey origin. MT204 prevents soluble IL-2 from binding to intermediate-affinity IL-2 receptors and blocks CD25-bound IL-2 on high-affinity IL-2 receptors. MT204 has potently anti-proliferative activity with NKL cells and primary NK cells. MT204 has good tolerability and potent immunosuppressive activity in allogeneic skin graft model of rhesus monkey, promising for immunosuppressive and anti-proliferative therapy .

HY-P991749

Anti-Rat CD25 Antibody (OX-39)	Interleukin Related	Inflammation/Immunology
Anti-Rat CD25 Antibody (OX-39) recognizes the 55 kDa low-affinity *interleukin-2 receptor* α chain (IL-2R α, CD25)*. Anti-Rat CD25 Antibody (OX-39) interacts with a single class of sites on the alpha chain of the rat R-IL2* with a high affinity (K_d of 0.8 nM) and competes with IL2 binding on this chain (K_i of 0.53 nM). Anti-Rat CD25 Antibody (OX-39) is a weak inhibitor in vitro on IL2-induced proliferation and in vivo on allograft rejection. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .

HY-D3327

PE-AF700	Fluorescent Dye	Others
PE-AF700 is a tandem fluorescent dye used for flow cytometry, consisting of the donor phycoerythrin (PE) and the acceptor Alexa Fluor 700 (AF700) (Ex/Em = 488 nm/715 nm) .

PE-AF700	Fluorescent Dyes
PE-AF700 is a tandem fluorescent dye used for flow cytometry, consisting of the donor phycoerythrin (PE) and the acceptor Alexa Fluor 700 (AF700) (Ex/Em = 488 nm/715 nm) .

Cat. No.	Product Name	Target	Research Area	Image

HY-108738

Daclizumab Ro 24-7375	Interleukin Related Apoptosis	Inflammation/Immunology Cancer
Daclizumab (Ro 24-7375) is a humanized, monoclonal antibody that blocks CD25 (α-subunit of the high-affinity interleukin-2 receptor (IL-2R-HA)). Daclizumab inhibits effector T cell activation, regulatory T cell (Treg) expansion and survival, and activation-induced T-cell apoptosis. Daclizumab increases *IL-2* bioavailability to bind to the intermediate-affinity *IL-2R* (IL-2R-IA), driving the expansion of anti-inflammatory CD56bright natural killer (NK) cells. Daclizumab can be used for multiple sclerosis and cancer research .

HY-P990736

Efercoleukin alfa	Interleukin Related	Inflammation/Immunology
Efercoleukin alfa is a recombinant fusion protein comprising an IL-2 fused to a human IgG1 Fc. Efercoleukin alfa binds the high-affinity IL-2 receptor alpha chain (CD25) .

HY-P991270

MT204	Interleukin Related	Inflammation/Immunology
MT204 is a humanized IgG1 antibody inhibitor targeting IL-2 of human and rhesus monkey origin. MT204 prevents soluble IL-2 from binding to intermediate-affinity IL-2 receptors and blocks CD25-bound IL-2 on high-affinity IL-2 receptors. MT204 has potently anti-proliferative activity with NKL cells and primary NK cells. MT204 has good tolerability and potent immunosuppressive activity in allogeneic skin graft model of rhesus monkey, promising for immunosuppressive and anti-proliferative therapy .

HY-P991749

Anti-Rat CD25 Antibody (OX-39)	Interleukin Related	Inflammation/Immunology
Anti-Rat CD25 Antibody (OX-39) recognizes the 55 kDa low-affinity *interleukin-2 receptor* α chain (IL-2R α, CD25)*. Anti-Rat CD25 Antibody (OX-39) interacts with a single class of sites on the alpha chain of the rat R-IL2* with a high affinity (K_d of 0.8 nM) and competes with IL2 binding on this chain (K_i of 0.53 nM). Anti-Rat CD25 Antibody (OX-39) is a weak inhibitor in vitro on IL2-induced proliferation and in vivo on allograft rejection. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .

Species:	Human (2) Rhesus Macaque (2) Rat (1) Mouse (4) Canine (1)
Tag:	His (4) Avi (1) Fc (6)
Source:	HEK293 (9) P. pastoris (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70631

	IL-2R beta/CD122 Protein, Human (HEK293, His) IL-2R beta; IL-2 R beta; IL-2RB; Interleukin-2 receptor subunit beta; IL2RB; IL-2 receptor subunit beta; IL-2R subunit beta; high affinity IL-2 receptor subunit beta; CD122	Human	HEK293
	IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Human (HEK293, His) is a recombinant human extracellular region of IL-2R beta (A27-D239) with a C-Terminal 6*His tags, which is produced in HEK293 cells.

HY-P7784

	IL-2R beta/CD122 Protein, Human (HEK293, Fc) rHuCD122, C-Fc; Interleukin-2 receptor subunit beta; IL2RB; IL-2 receptor subunit beta; IL-2R subunit beta; high affinity IL-2 receptor subunit beta; CD122	Human	HEK293
	IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Human (HEK293, Fc) is a recombinant human extracellular region of IL-2R beta (A27-D239) with a C-Terminal Fc tag, which is produced in HEK293 cells.

HY-P704710

	IL2RB-IL2RA-IL2RG Protein, Mouse (HEK293, Fc) IL2rbInterleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; high affinity IL-2 receptor subunit beta; p70-75; CD antigen CD122	Mouse	HEK293

HY-P71746

	IL-2R beta/CD122 Protein, Mouse (P.pastoris, His) IL2rbInterleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; high affinity IL-2 receptor subunit beta; p70-75; CD antigen CD122	Mouse	P. pastoris
	IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Mouse (P.pastoris, His) is a recombinant mouse IL-2R beta (27A-240E) with a N-Terminal His tag, which is produced in P.pastoris.

HY-P704711

	IL-2R beta/CD122 Protein, Mouse (HEK293, hFc) IL2rbInterleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; high affinity IL-2 receptor subunit beta; p70-75; CD antigen CD122	Mouse	HEK293
	IL-2R beta/CD122 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived IL-2R beta/CD122 protein, expressed by HEK293, with C-hFc tag.

HY-P705259

	IL2RB-IL2RG Heterodimer Protein, Mouse (Biotinylated, HEK293, Fc-Avi) IL2rbInterleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; high affinity IL-2 receptor subunit beta; p70-75; CD antigen CD122	Mouse	HEK293

HY-P76769

	IL-2R beta/CD122 Protein, Canine (HEK293, Fc) Interleukin-2 receptor subunit beta; IL2RB; high affinity IL-2 receptor subunit beta; CD122	Canine	HEK293
	IL-2R beta (CD122), a type I cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Canine (HEK293, Fc) is a recombinant canine IL-2R beta (M1-P244) with a C-Terminal hFc tag, which is produced in HEK293 cells.

HY-P76771

	IL-2R beta/CD122 Protein, Rat (HEK293, His) Interleukin-2 receptor subunit beta; IL2RB; high affinity IL-2 receptor subunit beta; CD122	Rat	HEK293
	IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Rat (HEK293, His) is a recombinant rat IL-2R beta (M1-E239) with a C-Terminal His tag, which is produced in HEK293 cells.

HY-P76773

	IL-2R beta/CD122 Protein, Rhesus Macaque (HEK293, His) Interleukin-2 receptor subunit beta; IL2RB; high affinity IL-2 receptor subunit beta; CD122	Rhesus Macaque	HEK293
	IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Rhesus Macaque (HEK293, His) is a recombinant Rhesus Macaque IL-2R beta with a C-Terminal His tag, which is produced in HEK293 cells.

HY-P76772

	IL-2R beta/CD122 Protein, Rhesus Macaque (HEK293, Fc) Interleukin-2 receptor subunit beta; IL2RB; high affinity IL-2 receptor subunit beta; CD122	Rhesus Macaque	HEK293
	IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Rhesus Macaque (HEK293, Fc) is a recombinant Rhesus Macaque IL-2R beta with a C-Terminal hFc tag, which is produced in HEK293 cells.

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