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histone deacetylase 6

" in MedChemExpress (MCE) Product Catalog:

標的別:	HDAC (18) Histone Demethylase (1) Apoptosis (5) c-Myc (1) HSP (1) Interleukin Related (1) MDM-2/p53 (1) Microtubule/Tubulin (1) NF-κB (1) NOD-like Receptor (NLR) (2) PERK (1) PROTACs (1) TNF Receptor (1) Wnt (1) β-catenin (1)
研究分野別:	Cancer (11) Cardiovascular Disease (1) Inflammation/Immunology (3) Neurological Disease (4)

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Targets Recommended: Histone Methyltransferase Histone Demethylase HDAC Histone Acetyltransferase

製品番号	製品名	Target	研究分野	構造式

HY-19328

ACY-775 2 Publications Verification	HDAC	Cardiovascular Disease Neurological Disease
ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC₅₀ of 7.5 nM . ACY775 also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) .

HY-115475

SW-100 4 Publications Verification	HDAC	Neurological Disease
SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC₅₀ of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier .

HY-159109

HDAC6-IN-46	HDAC	Neurological Disease
HDAC6-IN-46 (compound 12) is a selective histone deacetylase 6 (HDAC6) inhibitor with an IC₅₀ value of 6.2 nM. HDAC6-IN-46 can be used in Alzheimer's disease research .

HY-162616

SelSA	HDAC Apoptosis	Cancer
SelSA is a selective, orally active inhibitor for **histone deacetylase 6 (HDAC6) with IC₅₀ of 56.9 nM. SelSA inhibits the phosphorylation of ERK1/2. SelSA inhibits the proliferation of breast cancer cells and hepatocellular carcinoma cells with IC₅₀ of 0.58-2.6 μM, inhibits cell migration and invasion of Huh7, and induces apoptosis**. SelSA exhibits antitumor activity in mouse model .

HY-150586

PTG-0861	HDAC Apoptosis	Cancer
PTG-0861 is a selective histone deacetylase 6 (HDAC6) inhibitor with the IC₅₀ value of 5.92 nM. PTG-0861 induces apoptosis and can be used in the study of acute myeloid leukemia, multiple myeloma and other hematological cancers .

HY-179421

PROTAC HDAC6 degrader 7	PROTACs HDAC NF-κB NOD-like Receptor (NLR) Interleukin Related TNF Receptor	Inflammation/Immunology
PROTAC HDAC6 degrader 7 is an orally active, highly efficient, and selective PROTAC degrader targeting histone deacetylase 6 (HDAC6) (IC₅₀ = 118 nM). PROTAC HDAC6 degrader 7 can eliminate both the catalytic and zinc-finger ubiquitin-binding domain. PROTAC HDAC6 degrader 7 inhibits NLRP3 inflammasome assembly and activation, as well as blocks NF-κB signaling, thereby reducing the transcription and release of key inflammatory factors. PROTAC HDAC6 degrader 7 can reduce the mRNA levels of NLRP3, pro-IL-1β, TNF-α, and IL-6. PROTAC HDAC6 degrader 7 can be used for the study of inflammatory bowel disease (IBD) .

HY-163503

HDAC6-IN-38	HDAC	Cancer
HDAC6-IN-38 (Compound Z-7) is an inhibitor for histone deacetylase 6 (HDAC6), with an IC₅₀ of 3.25 nM. HDAC6-IN-38 inhibits proliferation of cells MGC 803 .

HY-158308

HDAC6-IN-41	HDAC	Cancer
HDAC6-IN-41 (Compound E24) is a selective inhibitor for histone deacetylase 6 (HDAC6), with IC₅₀ of 14 and 422 nM, for HDAC6 and HDAC8, respectively. HDAC6-IN-41 upregulates the acetylation of α-tubulin and histone site SMC3 .

HY-131970

LSD1/HDAC6-IN-1	Histone Demethylase HDAC	Cancer
LSD1/HDAC6-IN-1 is an orally active dual inhibitor of *lysine specific demethylase 1(LSD1)/Histone* deacetylase 6 (HDAC6)**, with anti-tumor activity. LSD1/HDAC6-IN-1 can be used for the research of multiple myeloma (MM) .

HY-W718894

(R)-Dihydrolipoic acid	HDAC	Others
(R)-Dihydrolipoic acid is a compound that inhibits histone deacetylase 6 (HDAC6) activity. The structure of its complex with HDAC6 has been resolved. (R)-Dihydrolipoic acid can inhibit HDAC6 through specific interactions, providing a basis for understanding the relationship between HDAC function and oxidative stress.

HY-174149

HDAC6-IN-59	HDAC	Cancer
HDAC6-IN-59 (Compound 38k) is a highly selective histone deacetylase 6 (HDAC6) inhibitor (IC₅₀=3.12 nM, with 352-fold selectivity over HDAC1). HDAC6-IN-59 is promising for research of esophageal cancer .

HY-152235

HDAC6-IN-15	HDAC	Neurological Disease Cancer
HDAC6-IN-15 is a selective histone deacetylase 6 (HDAC6) inhibitor. HDAC6-IN-15 has potent inhibitory activity for HDAC6 with IC₅₀ value of 38.2 nM. HDAC6-IN-15 can be used for the research of cancer and neurodegenerative diseases .

HY-173555

HDAC6-IN-54	HDAC NOD-like Receptor (NLR)	Inflammation/Immunology
HDAC6-IN-54 (Compound 9m) is a highly selective HDAC6 (histone deacetylase 6) inhibitor with an IC₅₀ value of 0.021 μM. HDAC6-IN-54 blocks the activation of the NLRP3 inflammasome, which alleviates symptoms of NLRP3 inflammasome-related diseases such as acute peritonitis, inflammatory bowel disease, and psoriasis .

HY-149371

HDAC6-IN-16	HDAC Apoptosis	Cancer
HDAC6-IN-16 (compound 5c) is a histone deacetylase 6 (HDAC6) inhibitor, based on Quinazolin-4(3H)-One. HDAC6-IN-16 exhibits anticancer effect, inhibits colony-forming. And HDAC6-IN-16 arrests cell cycle at G2 phase and induces apoptosis .

HY-175467

HDAC6/HSP90-IN-3	HSP HDAC	Cancer
HDAC6/HSP90-IN-3 (Compound 17) is an orally active dual histone deacetylase 6 (HDAC6) and heat shock protein 90 (HSP90) inhibitor with IC₅₀ values of 28 nM and 0.88 μM, respectively. HDAC6/HSP90-IN-3 is promising for research of malignant tumors such as prostate cancer .

HY-173184

HDAC6-IN-53	HDAC	Inflammation/Immunology
HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC₅₀ of 19.65 nM. HDAC6-IN-53 exerts the activity of inhibiting the phenotype of idiopathic pulmonary fibrosis (IPF) by suppressing the collagen expression induced by TGF-β1, and it has demonstrated a good therapeutic effect in a mouse model of pulmonary fibrosis induced by Bleomycin (HY-17565A). HDAC6-IN-53 can be used in the research of idiopathic pulmonary fibrosis and other related pulmonary fibrosis diseases.

HY-181541

HIT211504993	HDAC Apoptosis Wnt β-catenin MDM-2/p53 c-Myc	Cancer
HIT211504993 is a selective histone deacetylase 6 (HDAC6) inhibitor with an IC₅₀ of 0.070 μM. HIT211504993 suppresses cancer cell proliferation, cause G1 phase cell cycle arrest and induces apoptosis. HIT211504993 inhibits Myc-driven tumorigenesis via nucleocytoplasmic acetylation, p53 modulation, and Wnt/β-catenin signaling modulation. HIT211504993 inhibits tumor growth in a colon cancer xenograft mouse model. HIT211504993 can be used for the research of colon cancer .

HY-181579

HDAC6-IN-74	HDAC Apoptosis PERK Microtubule/Tubulin	Cancer
HDAC6-IN-74 is an orally active, selective histone deacetylase 6 (HDAC6) inhibitor with an IC₅₀ of 0.036 μM. HDAC6-IN-74 induces tumor cell apoptosis, arrests cells at the S phase of the cell cycle, and impairs cell migration, invasion and colony-forming abilities. HDAC6-IN-74 exerts anticancer effects with no obvious toxicity. HDAC6-IN-74 can be used in the research of cancers such as liver cancer .

Species:	Human (2)
Tag:	His (2)
Source:	Sf9 insect cells (1) E. coli (1)

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HY-P72224

	HDAC6 Protein, Human (His) 1 Publications Verification CPBHM; FLJ16239; HD 6; HD6; HDAC 6; HDAC6; HDAC6_HUMAN; histone deacetylase 6 HD6; ; histone deacetylase 6; JM 21; JM21; KIAA0901; OTTHUMP00000032398; OTTHUMP00000197663; PPP1R90; Protein phosphatase 1 regulatory subunit 90	Human	E. coli
	The HDAC6 protein coordinates multiple functions, deacetylating histones and proteins such as tubulin and CTTN. Its role in epigenetic repression affects transcription, cell cycle, and development. HDAC6 Protein, Human (His) is the recombinant human-derived HDAC6 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P704024

	HDAC6 Protein, Human (sf9, His) CPBHM; FLJ16239; HD 6; HD6; HDAC 6; HDAC6; HDAC6_HUMAN; histone deacetylase 6 HD6; ; histone deacetylase 6; JM 21; JM21; KIAA0901; OTTHUMP00000032398; OTTHUMP00000197663; PPP1R90; Protein phosphatase 1 regulatory subunit 90	Human	Sf9 insect cells
	The HDAC6 protein coordinates multiple functions, deacetylating histones and proteins such as tubulin and CTTN. Its role in epigenetic repression affects transcription, cell cycle, and development. HDAC6 Protein, Human (sf9, His) is the recombinant human-derived HDAC6 protein, expressed by Sf9 insect cells, with C-8*His labeled tag.

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Host:	Mouse (2) Rabbit (1)
Reactivity:	Human (3) Mouse (1) Rat (3)
Application:	IHC-P (1) ICC/IF (1) IP (1) WB (3) ELISA (1)
Isotype:	IgG (1) IgG2a (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2)
Modification:	Unmodified (2)

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HY-P86103

	HDAC6 Antibody (YA5795) HDAC6; KIAA0901; JM21; histone deacetylase 6; HD6	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	HDAC6 Antibody (YA5795) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HDAC6.

HY-P80701

	HDAC6 Antibody (YA740) HDAC6; KIAA0901; JM21; histone deacetylase 6; HD6	WB	Human, Rat
	HDAC6 Antibody (YA740) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HDAC6.

HY-P80701A

	HDAC6 Antibody (YA740)(PBS only) HDAC6; KIAA0901; JM21; histone deacetylase 6; HD6	WB	Human, Rat
	HDAC6 Antibody (YA740) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HDAC6.

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