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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
hyperthyroidism
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "hyperthyroidism" in MCE Product Catalog:
3
3 Cited Publications
Synonyms: 6-n-Propylthiouracil; 6-Propyl-2-thiouracil; PTU
Forschungsgebiete:
Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research .
2
2 Cited Publications
Art. -Nr.: HY-B0558
CAS. Nr.: 22232-54-8
Target:
Forschungsgebiete:
Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research .
1
Target:
Forschungsgebiete:
Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Thyrotropin (TSH, Pretiron) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid. Thyrotropin induces transcriptional regulation of TH-gatekeeper genes in tanycytes through the Tshr/Gαq/PKC pathway. Thyrotropin prevents Apoptosis. Thyrotropin has an association of low levels with increased bone remodeling, reduced bone mass and a high fracture risk in mice. Thyrotropin is promising for research of skeletal remodeling, hyperthyroidism .
Art. -Nr.: HY-P99670
CAS. Nr.: 2031153-61-2
Synonyms: CFZ-533; OM11-62MF
Target:
Forschungsgebiete:
Art. -Nr.: HY-127024A
CAS. Nr.: 1073179-55-1
Target:
Forschungsgebiete:
TR antagonist 2 (Compound 10a) is a competitive thyroid hormone receptors (TRα/β) antagonist (IC50=47 nM). TR antagonist 2 competes with triiodothyronine (T3) for binding to the ligand-binding domain of TR to block receptor-coactivator complex formation and inhibit target gene transcription, reducing thyroid hormone-mediated hypermetabolic effects. TR antagonist 2 is promising for research of hyperthyroidism (e.g., Graves' disease) and thyrotoxicosis .
Art. -Nr.: HY-B0208S
CAS. Nr.: 1160932-07-9
Art. -Nr.: HY-W069177
CAS. Nr.: 6336-50-1
Synonyms: 6-Benzyl-2-thiouracil
Target:
Forschungsgebiete:
Benzylthiouracil is an active pharmaceutical ingredient against hyperthyroidism .
Synonyms: 6-n-Propylthiouracil (Standard); 6-Propyl-2-thiouracil (Standard); PTU (Standard)
Forschungsgebiete:
Propylthiouracil (Standard) is the analytical standard of Propylthiouracil. This product is intended for research and analytical applications. Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research .
Art. -Nr.: HY-175178
CAS. Nr.: 1214645-87-0
Target:
Forschungsgebiete:
Arrestin-3 modulator-1 (Compound LSH-3) is an arrestin-3 modulator. Arrestin-3 modulator-1 binds arrestin-3 at the interdomain interface. Arrestin-3 modulator-1 enhances recruitment of arrestin-3 to phosphorylation-deficient β2AR in cells with increase of FRET levels. Arrestin-3 modulator-1 can be used for congenital disorders like retinal degeneration, hyperthyroidism and obesity research .
Art. -Nr.: HY-B0558S
Art. -Nr.: HY-W744953
Art. -Nr.: HY-B0558R
CAS. Nr.: 22232-54-8
Target:
Forschungsgebiete:
Carbimazole (Standard) is the analytical standard of Carbimazole. This product is intended for research and analytical applications. Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research .
Art. -Nr.: HY-14863
CAS. Nr.: 250384-82-8
Synonyms: CTA-018
Target:
Forschungsgebiete:
Lunacalcipol (CTA-018), as a vitamin D analogue, has a dual role in the pathogenesis of Chronic Kidney Disease (CKD), as an agonist of vitamin D receptor and an antagonist of cytochrome P450 enzyme 24-hydroxylase. Lunacalcipol binds to VDR and regulates transcriptional activity of VDR by influencing ligand binding affinity, ligand-dependent coactivator recruitment or inhibitory factor dissociation, efficiency of ligand entry into target cells, tissue specificity and different metabolism of ligand. Lunacalcipol can be used in the study of CKD, especially Secondary Hyperparathyroidism (sHPT) .
Art. -Nr.: HY-186138
CAS. Nr.: 1073180-47-8
Target:
Forschungsgebiete:
TR modulator-1 (compound 10c) is a selective thyroid hormone receptor (TR) modulator. TR modulator-1 can be used in the research of hyperthyroidism and thyrotoxicosis .
Art. -Nr.: HY-186138A
Target:
Forschungsgebiete:
TR modulator-1 (compound 10c) bromide is a selective thyroid hormone receptor (TR) modulator. TR modulator-1 bromide can be used in the research of hyperthyroidism and thyrotoxicosis .
Art. -Nr.: HY-L182
283 compounds
Fatty acids (FAs) are the main components of lipids. The synthesis of fatty acids mainly involves the Triglyceride (TG) cycle and De Novo Lipogenesis (DNL). Fatty acids which exist widely in organisms are components of cell membranes and play an indispensable role in cell signaling. In addition, FFAs can be taken up from circulating plasma by all mitochondria-containing cells, and they are metabolized by β-oxidation and the citric acid cycle to release large amounts of energy in the form of ATP. Abnormal fatty acid metabolism is associated with the occurrence and development of cardiovascular diseases, diabetes, fatty liver, hyperthyroidism, and other diseases.
MCE offers a unique collection of fatty acid compounds. Fatty Acids Compound Library is an important tool for the study of energy metabolism and drug development of metabolism-related diseases.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
