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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
kinesin spindle protein
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "kinesin spindle protein" in MCE Product Catalog:
7
7 Publications Verification
Synonyms: ARRY-520
Research Areas:
Filanesib (ARRY-520) is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity .
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Research Areas:
Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.
7
7 Publications Verification
Cat. No.: HY-15187C
CAS No.: 1385020-40-5
Synonyms: ARRY-520 hydrochloride
Filanesib hydrochloride (ARRY-520 hydrochloride) is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib hydrochloride induces cell death by apoptosis in vitro. Filanesib hydrochloride has potent anti-proliferative activity .
Cat. No.: HY-50672
CAS No.: 845256-65-7
Target:
Research Areas:
MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC50 of 2.2 nM and a pKa of 7.6. MK-0731 is >20,000 fold selectivity against other kinesins. MK-0731 induces mitotic arrest and induces apoptosis in tumors. MK-0731 provides significant antitumor efficacy .
AZD4877 is another isostere to Ispinesib (HY-50759)and also a kinesin spindle protein (Eg5) inhibitor with IC50 of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity .
Synonyms: (R)-ARRY-520
Target:
Research Areas:
(R)-Filanesib ((R)-ARRY-520) is an isomer of Filanesib (HY-15187). Filanesib (ARRY-520) is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity .
Cat. No.: HY-177285
CAS No.: 1161925-41-2
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Research Areas:
NVP-BQS481 (Compound 1) is a selective Kinesin spindle protein-5 (Eg5) inhibitor with an IC50< 0.5 nM. NVP-BQS481 has significant antimitotic and antitumor activity (IC50: 0.0.9 nM for SK-OV-3ip cells). NVP-BQS481 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) .
Cat. No.: HY-157338
CAS No.: 2231135-69-4
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NHS-Ala-Ala-Asn-active metabolite is a cleavable antibody-drug conjugate (ADC) linker for synthesis of kinesin spindle protein (KSP)inhibitor .
Cat. No.: HY-177613
CAS No.: 3031494-36-4
Synonyms: AD12115
ALN-12115 is a siRNA that targets kinesin spindle protein (KSP), and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for KSP and VEGF with potential antitumor activity.
Cat. No.: HY-177613A
Synonyms: AD12115 sodium
ALN-12115 sodium is a siRNA that targets kinesin spindle protein (KSP), and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for KSP and VEGF with potential antitumor activity.
Cat. No.: HY-177614
Synonyms: AD3133 sodium
ALN-3133 sodium is a siRNA that targets VEGF, and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for kinesin spindle protein (KSP) and VEGF with potential antitumor activity.
Cat. No.: HY-15187B
CAS No.: 1781834-99-8
Synonyms: ARRY-520 TFA
Research Areas:
Filanesib TFA (ARRY-520 TFA) is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib TFA induces cell death by apoptosis in vitro. Filanesib TFA has potent anti-proliferative activity .
Cat. No.: HY-122130
CAS No.: 1146209-50-8
Synonyms: MK-8267
SCH 2047069 (MK-8267) is an orally active kinesin spindle protein (KSP) inhibitor (Kd: 0.5 nM) that can cross the blood-brain barrier. SCH 2047069 exhibits an IC50 value of ≤ 5 nM against the KSP ATPase. SCH 2047069 exhibits broad-spectrum antitumor activity. SCH 2047069 can induce mitotic arrest and apoptosis in tumor cells. SCH 2047069 can be used in the research of tumors such as ovarian cancer, colon cancer, glioblastoma, and lymphoma .
Cat. No.: HY-168725
CAS No.: 3099825-86-9
PROTAC KSP degrader 1 is a KSP PROTAC degrader with a DC50 of 114.8 nM. PROTAC KSP degrader 1 induces ubiquitination and degradation of KSP protein. PROTAC KSP degrader 1 induces G2/M phase arrest of the cell cycle. PROTAC KSP degrader 1 triggers Apoptosis. PROTAC KSP degrader 1 exhibits anticancer activity against colon cancer. PROTAC KSP degrader 1 can be used for the research of colon cancer, lung cancer and breast cancer .
Cat. No.: HY-50759R
CAS No.: 336113-53-2
Synonyms: SB-715992 (Standard); CK-0238273 (Standard)
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Ispinesib (Standard) is the analytical standard of Ispinesib. This product is intended for research and analytical applications. Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.
Cat. No.: HY-117440
CAS No.: 1338701-15-7
4'-Methoxy-S-trityl-L-cysteinol is an allosteric inhibitor of vertebrate Kinesin Spindle Protein (KSP). 4'-Methoxy-S-trityl-L-cysteinol significantly enhances its inhibitory activity against NCI60 tumor cells by modifying the trityl and cysteine groups. Its EC50 for bipolar spindle formation is 28 μM, showing stronger inhibitory potency than the parent molecule and monastrol.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
