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Results for "

kinesin spindle protein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Kinesin (19) ADC Linker (1) ADC Payload (1) Apoptosis (10) Drug Derivative (1) Lipoxygenase (1) Mitosis (2) PROTACs (1) Reference Standards (1) VEGFR (1)
By Research Areas:	Cancer (20) Neurological Disease (1)
Oligonucleotides:	siRNA drugs (3) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Kinesin Mps1

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-15187

Filanesib Maximum Cited Publications 7 Publications Verification ARRY-520	Kinesin Apoptosis	Cancer
Filanesib (ARRY-520) is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC₅₀ of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity .

HY-50759

Ispinesib Maximum Cited Publications 7 Publications Verification SB-715992; CK-0238273	Kinesin Apoptosis	Cancer
Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a K_{i app} of 1.7 nM.

HY-50672

MK-0731	Kinesin Apoptosis Lipoxygenase	Cancer
MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC₅₀ of 2.2 nM and a pK_a of 7.6. MK-0731 is >20,000 fold selectivity against other kinesins. MK-0731 induces mitotic arrest and induces apoptosis in tumors. MK-0731 provides significant antitumor efficacy .

HY-13224

AZD4877	Kinesin Apoptosis Mitosis	Cancer
AZD4877 is another isostere to Ispinesib (HY-50759)and also a *kinesin* spindle protein (Eg5) inhibitor with IC₅₀ of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity .

HY-15187A

(R)-Filanesib (R)-ARRY-520	Kinesin	Cancer
(R)-Filanesib ((R)-ARRY-520) is the R-enantiomer of Filanesib (HY-15187). Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor with an IC₅₀ of 6 nM.

HY-177285

NVP-BQS481	Kinesin ADC Payload	Cancer
NVP-BQS481 (Compound 1) is a selective Kinesin spindle protein-5 (Eg5) inhibitor with an IC₅₀< 0.5 nM. NVP-BQS481 has significant antimitotic and antitumor activity (IC₅₀: 0.0.9 nM for SK-OV-3ip cells). NVP-BQS481 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) .

HY-124790

KSP-IA	Kinesin Mitosis	Cancer
KSP-IA (compound 17) is a potent kinesin spindle protein (KSP) inhibitor with an IC₅₀ value of 3.6 nM. KSP-IA inhibits cell mitosis .

HY-157338

NHS-Ala-Ala-Asn-active metabolite	ADC Linker Kinesin	Cancer
NHS-Ala-Ala-Asn-active metabolite is a cleavable antibody-drug conjugate (ADC) linker for synthesis of kinesin spindle protein (KSP)inhibitor .

HY-15187C

Filanesib hydrochloride Maximum Cited Publications 7 Publications Verification ARRY-520 hydrochloride	Kinesin Apoptosis	Neurological Disease Cancer
Filanesib (ARRY-520) hydrochloride is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC₅₀ of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity .

HY-177614

ALN-3133 sodium AD3133 sodium	VEGFR	Cancer
ALN-3133 sodium is a siRNA that targets VEGF, and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for kinesin spindle protein (KSP) and VEGF with potential antitumor activity.

HY-177613A

ALN-12115 sodium AD12115 sodium	Kinesin	Cancer
ALN-12115 sodium is a siRNA that targets kinesin spindle protein (KSP), and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for KSP and VEGF with potential antitumor activity.

HY-177613

ALN-12115 AD12115	Kinesin	Cancer
ALN-12115 is a siRNA that targets kinesin spindle protein (KSP), and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for KSP and VEGF with potential antitumor activity.

HY-15187B

Filanesib TFA ARRY-520 TFA	Kinesin	Cancer
Filanesib TFA (ARRY-520 TFA) is a selective kinesin spindle protein (KSP) inhibitor, with an IC₅₀ of 6 nM for human KSP. Filanesib TFA induces cell death by apoptosis in vitro. Filanesib TFA has potent anti-proliferative activity .

HY-122130

SCH 2047069 MK-8267	Kinesin Apoptosis	Cancer
SCH 2047069 (MK-8267) is an orally active kinesin spindle protein (KSP) inhibitor (K_d: 0.5 nM) that can cross the blood-brain barrier. SCH 2047069 exhibits an IC₅₀ value of ≤ 5 nM against the KSP ATPase. SCH 2047069 exhibits broad-spectrum antitumor activity. SCH 2047069 can induce mitotic arrest and apoptosis in tumor cells. SCH 2047069 can be used in the research of tumors such as ovarian cancer, colon cancer, glioblastoma, and lymphoma .

HY-168725

PROTAC KSP degrader 1	PROTACs Kinesin Apoptosis	Cancer
PROTAC KSP degrader 1 (Compound 21) is a PROTAC Degrader for **kinesin spindle protein (KSP), that degrades KSP in HCT-116 with DC₅₀ of 114.8 nM. PROTAC KSP degrader 1 inhibits the proliferation of HCT-116 with IC₅₀ of 10 nM, arrests the cell cycle of HCT-116 at G2/M phase, and induces apoptosis** in HCT-116. PROTAC KSP degrader 1 exhibits antitumor efficacy in mouse model . (Blue: Ligand for E3 Ligase Cereblon (HY-103596); Blank: Linker (HY-168726); Pink: Target Protein Ligand (HY-168727))

HY-50759A

Ispinesib mesylate SB-715992 mesylate; CK-0238273 mesylate	Kinesin Apoptosis	Cancer
Ispinesib (SB-715992) mesylate is a specific inhibitor of kinesin spindle protein (KSP), with a K_{i app} of 1.7 nM.

HY-50759R

Ispinesib (Standard) SB-715992 (Standard); CK-0238273 (Standard)	Kinesin Apoptosis Reference Standards	Cancer
Ispinesib (Standard) is the analytical standard of Ispinesib. This product is intended for research and analytical applications. Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.

HY-50759S

Ispinesib-d5 SB-715992-d₅	Kinesin Apoptosis	Cancer
Ispinesib-d₅ (SB-715992-d₅) is a deuterium labeled Ispinesib (HY-50759). Ispinesib is a specific inhibitor of kinesin spindle protein (KSP) .

HY-117440

4'-Methoxy-S-trityl-L-cysteinol	Kinesin	Cancer
4'-Methoxy-S-trityl-L-cysteinol is an allosteric inhibitor of vertebrate Kinesin Spindle Protein (KSP). 4'-Methoxy-S-trityl-L-cysteinol significantly enhances its inhibitory activity against NCI60 tumor cells by modifying the trityl and cysteine groups. Its EC50 for bipolar spindle formation is 28 μM, showing stronger inhibitory potency than the parent molecule and monastrol.

HY-179355

KSP-IN-1	Kinesin	Cancer
KSP-IN-2 (compound 12) is a kinesin spindle protein (KSP) inhibitor with an IC₅₀ of 450 nM .

HY-W198426

1-([1,1'-Biphenyl]-4-yl)urea Biphenyl-4-ylurea; (4-Phenylphenyl)urea	Drug Derivative	Others
1-(-4-yl) urea (compound 44) is a biphenyl urea analog .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	상품명	Species	Source	Image

HY-P701378

	KIF11 Protein, Human KIF11; kinesin-like protein KIF11; kinesin-like protein 1; kinesin-like spindle protein HKSP; kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5	Human	E. coli
	KIF11 Protein, a pivotal motor protein, orchestrates mitotic spindle formation and aids in Golgi-to-surface protein transport. Beyond mitosis, it engages in complex interactions, binding to thyroid hormone receptor, participating in chromatin remodeling, and interacting with NEK6, RARRES1, and AGBL2. This multifaceted role highlights KIF11's diverse contributions to cellular processes. KIF11 Protein, Human is the recombinant human-derived KIF11 protein, expressed by E. coli , with tag free.

HY-P701379

	KIF11 Protein, Human (His) KIF11; kinesin-like protein KIF11; kinesin-like protein 1; kinesin-like spindle protein HKSP; kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5	Human	E. coli
	KIF11 Protein, a pivotal motor protein, orchestrates mitotic spindle formation and aids in Golgi-to-surface protein transport. Beyond mitosis, it engages in complex interactions, binding to thyroid hormone receptor, participating in chromatin remodeling, and interacting with NEK6, RARRES1, and AGBL2. This multifaceted role highlights KIF11's diverse contributions to cellular processes. KIF11 Protein, Human (His) is the recombinant human-derived KIF11 protein, expressed by E. coli , with N-6*His labeled tag.

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Ispinesib-d5
Ispinesib-d₅ (SB-715992-d₅) is a deuterium labeled Ispinesib (HY-50759). Ispinesib is a specific inhibitor of kinesin spindle protein (KSP) .

Host:	Mouse (3)
Reactivity:	Human (3)
Application:	ICC/IF (3) IP (3) WB (3)
Isotype:	IgG1 (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2)
Modification:	Unmodified (2)

Cat. No.	Compare	상품명	Application	Reactivity	Image

HY-P85489

	Eg5 Antibody (YA5181) EG5; HKSP; KIF11; KIF11_HUMAN; kinesin family member 11; kinesin like protein 1; kinesin like spindle protein HKSP; kinesin-like protein 1; kinesin-like protein KIF11; kinesin-like spindle protein HKSP; kinesin-related motor protein Eg5; KNSL1; MCLMR; Thyroid receptor interacting protein 5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5; TRIP5.	WB, IP, ICC/IF	Human
	Eg5 Antibody (YA5181) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Eg5.

HY-P80647

	Eg5 Antibody (YA776) KIF11; EG5; KNSL1; TRIP5; kinesin-like protein KIF11; kinesin-like protein 1; kinesin-like spindle protein HKSP; kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5	WB, ICC/IF, IP	Human
	Eg5 Antibody (YA776) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Eg5.

HY-P80647A

	Eg5 Antibody (YA776)(PBS only) KIF11; EG5; KNSL1; TRIP5; kinesin-like protein KIF11; kinesin-like protein 1; kinesin-like spindle protein HKSP; kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5	WB, ICC/IF, IP	Human
	Eg5 Antibody (YA776) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Eg5.

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HY-177614

ALN-3133 sodium AD3133 sodium		siRNAs siRNA drugs
ALN-3133 sodium is a siRNA that targets VEGF, and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for kinesin spindle protein (KSP) and VEGF with potential antitumor activity.

HY-177613A

ALN-12115 sodium AD12115 sodium		siRNAs siRNA drugs
ALN-12115 sodium is a siRNA that targets kinesin spindle protein (KSP), and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for KSP and VEGF with potential antitumor activity.

HY-177613

ALN-12115 AD12115		siRNAs siRNA drugs
ALN-12115 is a siRNA that targets kinesin spindle protein (KSP), and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for KSP and VEGF with potential antitumor activity.

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